Mesalamine 500 mg : Uses, Dosage & Side Effects

Living with inflammatory bowel disease (IBD) is not easy. If you’re someone who struggles with ulcerative colitis or other forms of chronic colon inflammation, you know how important it is to find a treatment that works — consistently and safely. That’s where mesalamine 500 mg comes in.

Mesalamine 500 mg is a well-established anti-inflammatory medication used to control and prevent flare-ups in IBD. One of the most reliable and clinically tested versions of this medicine is MESALMILE 500 PR, a delayed-release (DR) mesalamine tablet manufactured by Steris Healthcare. Whether you’re newly diagnosed or looking for better maintenance therapy, understanding your options — especially mesalamine 500 mg — can lead to better outcomes.

What Is Mesalamine 500 mg and How Does It Help?

Mesalamine 500 mg is an oral anti-inflammatory drug that targets inflammation in the colon, especially for patients with ulcerative colitis, proctitis, or Crohn’s colitis. The DR (delayed-release) formulation ensures that the medication is released directly in the colon, where it's needed the most — bypassing the stomach and small intestine.

MESALMILE 500 PR contains mesalamine DR 500 mg, providing:

• Targeted delivery to the lower GI tract

• Effective symptom control

• Protection against long-term complications

Unlike steroids, mesalamine works locally and is not systemically absorbed in high amounts, making it suitable for long-term use with fewer systemic side effects.

Dosage of Mesalamine 500 mg (MESALMILE 500 PR)

• For mild to moderate ulcerative colitis, the usual adult dose is 2.4 to 4.8 grams per day divided into two or three doses. This usually translates to taking 4 to 6 tablets of mesalamine 500 mg daily, often given as 2 tablets two or three times a day.

• For maintenance therapy to prevent relapse, a typical dose is 1.5 to 2.4 grams daily, which is 3 to 5 tablets of 500 mg mesalamine daily, usually given in divided doses.

• Dosage may be adjusted by your doctor depending on your response and tolerance.

• Always follow your healthcare provider's instructions carefully and do not change your dose without consulting them.

Patients should continue taking mesalamine regularly even if symptoms improve, as stopping treatment may cause relapse.

How Does Mesalamine DR Work?

(Mesalamine Mechanism of Action)

The mechanism of action of mesalamine involves blocking the production of certain chemical messengers (like prostaglandins and leukotrienes) responsible for inflammation in the bowel lining. These chemicals cause:

• Redness and swelling

• Diarrhea and urgency

• Bleeding and abdominal pain

By inhibiting these inflammatory pathways, mesalamine tablets help:

• Heal the colon

• Maintain remission

• Improve quality of life

The delayed-release nature of MESALMILE 500 PR ensures that mesalamine is not broken down too early, allowing maximum drug activity where it’s most needed.

Uses of Mesalamine 500 mg (MESALMILE 500 PR)

Mesalamine 500 dr, available as MESALMILE 500 PR, is primarily used for the treatment and management of inflammatory bowel diseases (IBD). Its main goal is to reduce inflammation in the colon and maintain long-term remission of symptoms. Here's a closer look at its common uses:

1. Ulcerative Colitis (Mild to Moderate)

• MESALMILE 500 PR is commonly prescribed for inducing remission during flare-ups of ulcerative colitis.

• It helps relieve symptoms like bloody diarrhea, abdominal pain, rectal bleeding, and cramping by reducing inflammation in the lining of the colon.

2. Maintenance Therapy

• Once remission is achieved, mesalamine 500 mg is often continued as maintenance therapy to prevent future flare-ups.

• Regular use can help reduce the frequency and severity of relapses.

3. Proctosigmoiditis and Proctitis

• These are forms of ulcerative colitis that affect the lower part of the colon (rectum and sigmoid colon).

• Mesalamine DR tablets are particularly effective because they release the medicine directly where it's needed.

4. Crohn’s Disease (Off-Label Use)

• Though less commonly prescribed, mesalamine may be used in some cases of Crohn's disease, especially when inflammation is mild and located in the colon.

• Always consult your doctor for suitability in Crohn’s-related cases.

5. Prevention of Post-Surgical Recurrence

• In some patients who have undergone surgery for IBD, mesalamine 500 mg may be used to prevent recurrence of inflammation in the intestinal lining.

Mesalamine Side Effects: What You Should Know

While mesalamine is generally well tolerated, it’s important to know the possible side effects. Most are mild and temporary.

Common Side Effects:

• Nausea

• Abdominal discomfort

• Headache

• Flatulence

• Mild diarrhea

Rare but Serious Side Effects:

• Allergic reactions (rash, itching)

• Liver or kidney function changes (especially in long-term use)

• Chest pain or breathing issues (extremely rare)

To ensure safe long-term use, regular kidney function tests may be recommended by your doctor.

Tip for patients: Always inform your doctor about other medications you're taking to avoid drug interactions.

Who Should Use MESALMILE 500 PR?

Ideal for:

• Patients with mild to moderate ulcerative colitis

• Those looking to maintain remission

• Individuals needing targeted therapy in the colon

Use with Caution:

• If allergic to salicylates or NSAIDs

• If you have known kidney or liver issues

• If you’re pregnant or breastfeeding (consult your doctor)

MESALMILE 500 PR is suitable for long-term management, helping prevent relapse and maintain a stable gut environment.

Patient Tips for Better Results with Mesalamine 500 mg

• Take your medication at the same time daily.

• Don’t stop abruptly — even if symptoms improve.

• Keep a symptom diary to track flares and triggers.

• Avoid spicy, processed foods during flare-ups.

• Stay in touch with your doctor for regular reviews.

Why Choose MESALMILE 500 PR by Steris Healthcare?

When it comes to your digestive health, quality and consistency matter. MESALMILE 500 PR is a top choice for patients and physicians alike because:

• It is manufactured by Steris Healthcare, a company known for its high standards, innovation, and commitment to patient wellness.

• The delayed-release technology provides targeted action where it’s needed, increasing treatment efficacy.

• Easy-to-swallow mesalamine tablets with a patient-friendly dosing schedule.

• Backed by clinical research and trusted by healthcare professionals across India and globally.

Steris Healthcare focuses on delivering quality-assured medications that empower patients to take control of chronic conditions with confidence.

Frequently Asked Questions

Q1: What is the difference between mesalamine DR and ER?

Mesalamine DR (Delayed Release) tablets release the medication after passing through the stomach, targeting the colon. ER (Extended Release) forms release the medication gradually over time, sometimes throughout the entire GI tract. The right form depends on your condition and your doctor’s recommendation.

Q2: How long does it take for mesalamine 500 mg to work?

It typically takes 2 to 4 weeks to see improvement in symptoms. Some patients may feel relief sooner, but for full benefits, consistent daily use is essential.

Q3: Can MESALMILE 500 PR be taken with food?

Yes, MESALMILE 500 PR can be taken with or without food. Taking it with meals may help reduce gastrointestinal discomfort.

Q4: Is it safe to use mesalamine long term?

Yes, mesalamine 500 mg is commonly used for long-term maintenance of ulcerative colitis. Routine blood and kidney function tests may be advised during prolonged use.

Q5: What is the maximum dosage of mesalamine?

The maximum recommended dose for mesalamine can range up to 4.8 grams (4800 mg) per day, depending on the patient’s needs and the formulation. Always follow your doctor’s prescribed dose.

Final Thoughts

If you are managing ulcerative colitis or other inflammatory bowel diseases, choose MESALMILE 500 PR mesalamine 500 mg tablets from Steris Healthcare for effective, targeted treatment. Consult your healthcare provider today to learn how this trusted delayed-release therapy can support your journey to better digestive health.

Start your path to relief and healing with MESALMILE 500 PR—quality medication designed with your well-being in mind. Contact your nearest pharmacy or doctor now!