Mesalamine 400 mg : Mechanism, Dosage, Side Effects

Living with inflammatory bowel disease (IBD)—especially conditions like ulcerative colitis (UC) or Crohn’s disease—can be mentally and physically exhausting. From unpredictable flare-ups and chronic pain to frequent bowel movements and fatigue, the condition often disrupts daily life. Fortunately, Mesalamine 400 mg is a trusted and clinically proven medication that offers effective relief from IBD symptoms.

One of the most recommended and patient-trusted formulations is MESALMILE 400, a Mesalamine Extended-Release 400 mg tablet from Steris Healthcare, a pharmaceutical company committed to quality, affordability, and patient care.

Whether you are newly diagnosed or managing IBD for years, understanding your medication is crucial. This article breaks down everything you need to know about mesalamine 400 mg, including how it works, how to use it, side effects, and why MESALMILE 400 could be the right choice for you.

What is Mesalamine 400 mg?

Mesalamine, also known as 5-aminosalicylic acid (5-ASA), is an anti-inflammatory drug primarily used to treat inflammation in the colon caused by ulcerative colitis and, in some cases, Crohn’s disease. The 400 mg strength in extended-release (ER) form allows the drug to be slowly released throughout the colon, offering long-lasting relief with fewer doses.

MESALMILE 400, manufactured by Steris Healthcare, is a premium mesalamine ER 400 mg tablet designed to help patients:

• Achieve and maintain remission

• Control flare-ups

• Protect the colon lining

• Reduce the frequency of painful symptoms

The extended-release mechanism makes it ideal for chronic, long-term therapy in managing inflammatory bowel disease.

Mesalamine Mechanism of Action: How It Works

Understanding how mesalamine 400 mg works can help patients trust their treatment and stay committed to long-term therapy.

Mesalamine acts locally in the colon to suppress inflammatory chemicals such as prostaglandins and leukotrienes. These substances are responsible for causing:

• Redness and swelling in the gut lining

• Mucus and blood in stools

• Cramping, urgency, and frequent diarrhea

By reducing inflammation at the source, mesalamine helps:

• Heal the intestinal lining

• Prevent further damage

• Relieve symptoms like bleeding, pain, and urgency

Unlike corticosteroids or immunosuppressants, mesalamine is not systemically absorbed in large amounts, making it safer for long-term use with a lower risk of systemic side effects.

Dosage & Usage: How to Take Mesalamine ER 400 mg

Always follow your doctor's instructions when taking MESALMILE 400. Below is a general guideline:

• Initial treatment (acute flare-ups): 1.6 g to 2.4 g/day (i.e., 4–6 tablets divided into 2–3 doses daily)

• Maintenance therapy: 1.2 g to 2.4 g/day

• Route: Oral

• Swallow whole: Do not chew or crush. Doing so may affect drug release.

Your doctor may adjust your dose based on:

• Symptom severity

• Your weight and age

• Response to the treatment

Important: Continue the medication even when you feel better, unless advised otherwise. Discontinuing early can trigger a relapse.

Mesalamine Side Effects: What You Should Know

Most patients tolerate mesalamine 400 mg very well, but some may experience mild side effects:

Common side effects:

• Headache

• Nausea

• Abdominal pain

• Gas or bloating

• Diarrhea

Less common but serious:

• Kidney function issues (rare, especially with long-term use)

• Pancreatitis

• Allergic reactions (rash, itching, swelling)

Tip for patients: Make sure your doctor monitors your kidney function periodically while you're on mesalamine. Report any unusual symptoms immediately.

Who Should Use Mesalamine 400 mg?

Indicated for:

• Mild to moderate ulcerative colitis

• Maintenance of remission in UC

• Proctitis and proctosigmoiditis

• Sometimes used in Crohn’s colitis (as per doctor’s advice)

Not ideal for:

• Patients allergic to salicylates (aspirin-related drugs)

• Those with severe liver or kidney disease (unless closely monitored)

Always consult a gastroenterologist before starting therapy.

Patient Tips to Maximize Results

• Stick to your dosing schedule—set alarms if needed.

• Don’t skip doses, especially during remission.

• Stay hydrated and follow a low-residue or anti-inflammatory diet.

• Track your symptoms and bowel habits in a diary.

• Communicate openly with your healthcare provider about side effects or concerns.

Why Choose MESALMILE 400 by Steris Healthcare?

When it comes to your health, quality and trust matter. Here's why MESALMILE 400 stands out:

• Reliable extended-release formula: Ensures consistent delivery of mesalamine throughout the day.

• Manufactured by Steris Healthcare: A reputable pharmaceutical company known for its high standards and patient-first approach.

• Clinically backed: MESALMILE 400 has been developed with the latest research in mesalamine delivery systems.

• Patient-friendly packaging and dosing instructions for ease of use.

Whether you're newly diagnosed or managing a long-term condition, choosing MESALMILE 400 ensures you are getting a trusted, effective treatment.

Frequently Asked Questions

Q1: What is the maximum dosage of mesalamine?

The maximum dosage of mesalamine depends on the condition being treated and the form of the medication. For extended-release mesalamine, the dosage may go up to 4.8 grams per day (4800 mg), typically divided across multiple doses. However, always follow your doctor’s instructions—never exceed the prescribed dose.

Q2: Can I take MESALMILE 400 with food?

Yes, MESALMILE 400 can usually be taken with or without food. However, taking it with food may help reduce stomach upset.

Q3: How long does it take for mesalamine to work?

Most patients notice improvement within a few days to weeks, but full relief may take several weeks. Be patient and consistent with your dosage.

Q4: Is MESALMILE 400 safe for long-term use?

Yes, many patients use mesalamine 400 mg for long-term maintenance therapy. Regular check-ups with your doctor will ensure the medication is still working effectively and safely.

Conclusion

Living with inflammatory bowel diseases like ulcerative colitis doesn't have to mean living in discomfort or fear of the next flare-up. With mesalamine 400 mg, especially in the trusted form of MESALMILE 400 by Steris Healthcare, you have a reliable ally in your treatment journey.

This extended-release medication is designed to target the source of inflammation, helping you manage symptoms effectively and improve your quality of life. Whether you're starting treatment or seeking better maintenance options, MESALMILE 400 offers consistent relief backed by pharmaceutical expertise.

As always, speak with your doctor before making any changes to your medication routine. But remember—you’re not alone, and effective, safe treatments are available.