Divalproex Sodium 500 mg Extended-Release Tablets for Epilepsy, Bipolar Disorder & Migraine

Introduction

DIOWELPREX ER 500, containing divalproex sodium 500 mg, offers extended-release benefits, providing a controlled release of medication for consistent blood levels. Manufactured by Steris Healthcare Pvt Ltd, this formulation helps reduce dose frequency while improving compliance and minimizing side effects.

What is DIOWELPREX ER 500?

DIOWELPREX ER 500 is an extended-release formulation of divalproex sodium 500 mg, developed to offer stable plasma levels over 24 hours. The combination of valproic acid and sodium valproate in this compound helps treat a variety of central nervous system (CNS) conditions with a single daily dose.

Uses of DIOWELPREX ER 500

1. Epilepsy:

• Controls a broad range of seizure types, including absence seizures, generalized tonic-clonic seizures, and complex partial seizures.

2. Bipolar Disorder:

• Manages acute manic and mixed episodes and helps prevent relapse.

3. Migraine Prophylaxis:

• Used for preventing migraine attacks, especially in patients unresponsive to other therapies.

Mechanism of Action

Divalproex sodium enhances gamma-aminobutyric acid (GABA) levels in the brain—GABA is a key inhibitory neurotransmitter that calms overactive neurons. Additionally, it inhibits voltage-gated sodium channels and modulates calcium influx, helping in seizure prevention and mood stabilization.

Dosage and Administration

• Starting dose: Usually 10–15 mg/kg/day.

• Titration: Gradual increase based on clinical response and serum levels.

• Administration: Swallowed whole; do not crush or chew.

• Frequency: Typically once daily, preferably at the same time.

Side Effects of Divalproex 500 mg

Common Side Effects:

• Nausea, vomiting, or indigestion

• Headache or drowsiness

• Tremor or unsteadiness

• Hair thinning

• Weight gain

Serious Side Effects:

• Hepatotoxicity (liver damage)

• Pancreatitis

• Blood dyscrasias (e.g., low platelet count)

• Mood changes or suicidal thoughts

Report side effects to your healthcare provider immediately.

Precautions Before Use

• Avoid during pregnancy unless clearly indicated

• Regular liver function and blood monitoring are advised

• Use cautiously in elderly patients and those with kidney issues

• Avoid alcohol and sedatives

• Discontinue gradually under supervision to avoid withdrawal seizures

Drug Interactions

Divalproex sodium can interact with:

• Antiepileptics (phenytoin, lamotrigine, carbamazepine)

• Antibiotics (carbapenems like meropenem)

• Aspirin and anticoagulants (risk of bleeding)

• Oral contraceptives (reduced effectiveness)

• Sedatives and CNS depressants

Consult your physician before combining it with other drugs.

Why Choose Steris Healthcare Pvt Ltd?

• WHO-GMP certified production units

• Focus on innovative, affordable therapies

• Trusted by neurologists, psychiatrists, and general practitioners

• Patient-friendly formulations

• Nationwide availability with excellent customer support

FAQs

Q1: How long does it take for DIOWELPREX ER 500 to start working?
Usually, within a few days to a week, but full benefits may take longer.

Q2: Can this be taken alongside other epilepsy medicines?
Yes, but only under medical supervision due to interaction risks.

Q3: What monitoring is required?
Regular liver function tests, CBCs, and serum valproate levels.

Q4: Is it safe for children?
Yes, with adjusted doses as per pediatric guidance.

Q5: What if I miss a dose?
Take it as soon as you remember, but skip it if it's close to the next scheduled dose.

Conclusion

DIOWELPREX ER 500 offers reliable, extended protection against seizures, mood swings, and migraine episodes. With excellent tolerability and once-daily dosing convenience, it stands out as a preferred treatment option. Backed by Steris Healthcare Pvt Ltd, this formulation ensures top-tier quality, patient safety, and clinical efficacy.