Cycloserine 250 mg Tablet: View Uses, Benefits, Price & Side Effects.

Cycloserine 250 mg tablet is an important medication used primarily in the treatment of drug-resistant tuberculosis (TB). It belongs to a class of antibiotics that work by inhibiting bacterial cell wall synthesis, thereby controlling the spread of TB-causing bacteria. With increasing resistance to conventional anti-tuberculosis drugs, Cycloserine has become a critical second-line agent, especially in multi-drug resistant tuberculosis (MDR-TB) therapy. In this article, we’ll explore Cycloserine 250 mg uses, benefits, dosage, side effects, and other essential details to help patients and healthcare professionals understand its role and importance.

What is Cycloserine 250 mg?

Cycloserine 250 mg is an oral broad-spectrum antibiotic prescribed mainly for treating Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis. It is not typically used as a first-line treatment, but rather as part of a multi-drug regimen in patients who do not respond to primary medications such as isoniazid or rifampin. Cycloserine is available in tablet or capsule form, often labeled as cap Cycloserine 250 mg, and should be used only under the supervision of a TB specialist or pulmonologist due to its potential neurotoxic effects and requirement for close monitoring. 

Cycloserine 250 mg Uses

1. Multi-Drug Resistant Tuberculosis (MDR-TB)

The most common indication for a Cycloserine 250 mg tablet is MDR-TB, where the patient’s strain of tuberculosis is resistant to at least isoniazid and rifampin. It helps suppress bacterial growth as part of a longer treatment regimen lasting 12–24 months.

2. Extensively Drug-Resistant Tuberculosis (XDR-TB)

Cycloserine may also be used in XDR-TB cases, in combination with other advanced anti-TB drugs.

3. Off-label Uses (rare cases)

Though not common, Cycloserine has been used off-label for certain infections caused by resistant gram-positive or gram-negative organisms.

How Does Cycloserine 250 mg Work?

Cycloserine 250 mg works by inhibiting the enzymes involved in bacterial cell wall synthesis, specifically alanine racemase and D-alanine:D-alanine ligase. Without an intact cell wall, the bacteria cannot survive or multiply. This mechanism makes it a bacteriostatic agent—it stops bacterial growth but does not kill the bacteria directly.

Its action is concentration-dependent, meaning its effectiveness increases with higher concentrations in the body (up to a safe therapeutic level).

Benefits of Cycloserine 250 mg Tablet

• Effective against resistant strains of Mycobacterium tuberculosis

• Oral administration—no need for injections

• Works synergistically when combined with other anti-TB drugs

• Useful in complex TB regimens

• Supports national TB control programs focused on MDR-TB management
   

Because of these advantages, cap Cycloserine 250 mg is widely used in TB hospitals, public health programs, and DOTS-plus centers worldwide.

Cycloserine 250 mg Dosage Guidelines

General Dosage:

• Adults: Typically Cycloserine 250 mg twice daily (morning and evening)

• In some cases, the dose may be increased to 500–750 mg per day in divided doses depending on tolerance and clinical response.

Maximum Dose:

• Should not exceed 1 g per day, as higher doses are associated with increased neurotoxicity.

Duration of Use:

• 6–24 months, based on the type of tuberculosis and combination therapy.

Administration Tips:

• Take with or without food (preferably with food to reduce gastric discomfort)

• Maintain a regular schedule for best results

• Do not skip doses or stop abruptly without medical advice

Cycloserine 250 mg Side Effects

Cycloserine is a powerful drug, and while effective, it may cause several side effects—especially neurological and psychiatric. Here are the most commonly reported Cycloserine 250 mg side effects:

Common Side Effects:

• Dizziness

• Headache

• Tremors

• Drowsiness

• Nausea

Serious Side Effects:

• Seizures

• Depression

• Psychosis (hallucinations, confusion, behavioral changes)

• Suicidal thoughts or behavior

• Peripheral neuropathy (tingling or numbness)
   

Rare Side Effects:

• Allergic rash

• Fever

• Liver enzyme elevation

Important: Due to these effects, regular neurological and psychiatric assessments are essential during treatment.

Precautions Before Using Cycloserine 250 mg

• Inform your doctor if you have:

  • History of seizures

  • Depression or other psychiatric illnesses

  • Alcoholism

  • Kidney disease

  • Liver dysfunction

• Avoid alcohol during treatment, as it increases the risk of seizures and mental disturbances.

• Use with caution in the elderly and patients with co-existing neurological issues.

• Patients may be given pyridoxine (Vitamin B6) alongside Cycloserine to minimize neurotoxic effects.

Drug Interactions with Cycloserine 250 mg Tablet

Avoid combining Cycloserine 250 mg with the following without consulting your physician:

• Alcohol

• Isoniazid (increases neurotoxicity)

• Phenytoin or other anti-epileptics

• Ethionamide (enhances CNS side effects)

• Psychiatric medications
   

Always inform your doctor about all medications and supplements you're taking.
 

Monitoring During Treatment

Regular monitoring is essential during treatment with Cycloserine 250 mg:

• Liver function tests (LFTs)

• Renal function tests (RFTs)

• Psychiatric evaluation

• Serum drug levels (if available)

• Vitamin B6 supplementation status

Cycloserine 250 mg Price in Steris Healthcare.

The Cycloserine 250 mg price in steris healthcare may vary depending on brand, manufacturer, and packaging. It is available under various generic and branded versions.

Approximate Price Range:

• ₹40 to ₹100 per tablet

• ₹600 to ₹1500 for a strip of 15 capsules (may vary)

Patients receiving treatment from government TB programs often get the medicine free of cost under DOTS-Plus schemes.

If you're purchasing from retail or online pharmacies, look for quality-assured brands like those manufactured by WHO-GMP certified companies.
 

Storage and Handling Instructions

• Store in a cool, dry place away from sunlight

• Keep out of reach of children

• Do not use after the expiry date

• Follow storage guidelines mentioned on the pac

Why Choose Steris Healthcare For Cycloserine 250 mg Tablet? 

Steris Healthcare is a leading name in the Indian pharmaceutical industry, known for its unwavering commitment to quality, safety, and patient-centric formulations. When it comes to critical anti-tuberculosis medications like Cycloserine 250 mg Tablet, Steris Healthcare stands out for offering high-purity, clinically tested, and GMP-certified formulations that meet both national and international healthcare standards. Their Cycloserine 250 mg tablet is specially designed for use in multi-drug resistant tuberculosis (MDR-TB) treatment regimens, ensuring reliable performance and therapeutic effectiveness.

What sets Steris Healthcare apart is its emphasis on precision manufacturing and rigorous quality control, which ensures each batch delivers consistent results. The formulation is carefully developed to provide maximum bioavailability, while minimizing the risks associated with side effects. Additionally, Steris Healthcare offers affordable pricing, making essential medicines like Cycloserine accessible to a broader segment of patients without compromising on quality.