Teneligliptin 20 mg + Metformin SR 1000 mg

Introduction

Diabetes mellitus is one of the most prevalent chronic diseases worldwide, characterized by high blood sugar levels that can lead to serious health complications like heart disease, kidney failure, and vision loss. Managing diabetes effectively is essential for preventing these complications, and this often involves the use of medications that help regulate blood sugar. One such combination therapy is TENELIGOLD M 1000, which contains Metformin SR (1000mg) and Teneligliptin (20mg). This formulation is designed to provide a comprehensive approach to controlling blood glucose levels in patients with type 2 diabetes.

In this article, we will delve into the key components of TENELIGOLD M 1000, examining their mechanisms of action, therapeutic uses, recommended dosage, possible side effects, and other important considerations.

What is TENELIGOLD M 1000?

TENELIGOLD M 1000 is a combination medication prescribed to manage type 2 diabetes mellitus, a condition where the body either becomes resistant to insulin or doesn't produce enough insulin to regulate blood sugar levels effectively. This medication combines two key drugs—Metformin SR (1000mg) and Teneligliptin (20mg)—to provide optimal glucose control.

1. Metformin SR (1000mg): Metformin is one of the most commonly prescribed medications for managing type 2 diabetes. It belongs to a class of drugs called biguanides and works by improving the body’s sensitivity to insulin, which in turn helps lower blood glucose levels. Metformin SR is the sustained-release (SR) form of the medication, which provides prolonged effects, minimizing fluctuations in blood glucose levels throughout the day.

2. Teneligliptin (20mg): Teneligliptin is a relatively newer drug used for the treatment of type 2 diabetes. It is classified as a DPP-4 inhibitor (dipeptidyl peptidase-4 inhibitor). By inhibiting the enzyme DPP-4, Teneligliptin increases the levels of incretin hormones such as GLP-1 (glucagon-like peptide-1), which help stimulate insulin secretion in response to food intake and decrease glucagon release, thus contributing to lower blood sugar levels.

The combination of Metformin SR and Teneligliptin in TENELIGOLD M 1000 provides a dual mechanism of action that enhances the efficacy of blood glucose control in type 2 diabetes patients.

Key Ingredients in TENELIGOLD M 1000

• Metformin SR (1000mg):

  • Mechanism of Action: Metformin works primarily by inhibiting glucose production in the liver, improving insulin sensitivity in muscle and fat cells, and enhancing the utilization of glucose in peripheral tissues. It also helps in reducing the absorption of glucose from the digestive tract.
  • Benefits: It helps to lower both fasting and postprandial (after meal) blood sugar levels, making it an essential medication for managing diabetes.

• Teneligliptin (20mg):

  • Mechanism of Action: As a DPP-4 inhibitor, Teneligliptin prevents the breakdown of incretin hormones, leading to enhanced insulin secretion after meals and reduced glucagon secretion, thereby lowering blood sugar levels.
  • Benefits: It not only helps control blood sugar but also has a lower risk of hypoglycemia (low blood sugar) compared to other anti-diabetic medications. Additionally, it does not cause weight gain, which is a common side effect of many diabetes medications.

Uses of TENELIGOLD M 1000

TENELIGOLD M 1000 is primarily indicated for the treatment of type 2 diabetes mellitus. It is used when diet, exercise, and lifestyle modifications alone are insufficient to control blood sugar levels. The combination of Metformin SR and Teneligliptin offers a more comprehensive approach to managing glucose levels, addressing both insulin resistance and impaired insulin secretion.

In addition to controlling blood glucose, TENELIGOLD M 1000 may also have beneficial effects on the overall metabolic profile, including improving lipid levels and reducing the risk of cardiovascular complications associated with diabetes.

Dosage and Administration

The dosage of TENELIGOLD M 1000 should always be prescribed by a healthcare provider, who will tailor the dosage based on the patient’s blood glucose levels, response to treatment, and other factors like kidney function and comorbidities. However, the general dosage guidelines for TENELIGOLD M 1000 are as follows:

• Adults: The usual starting dose is one tablet of TENELIGOLD M 1000 taken once daily with a meal. The tablet should be swallowed whole with water, and it is advisable to take it at the same time each day to help remember the dosage.
• Dosage Adjustments: In cases where blood glucose is not adequately controlled, the dosage may be increased. However, this should only be done under the supervision of a doctor.

Note: Patients with renal impairment (reduced kidney function) or other medical conditions may require a lower dose or alternative therapies. It is essential to follow your healthcare provider's instructions regarding dosage adjustments.

Side Effects of TENELIGOLD M 1000

While TENELIGOLD M 1000 is generally well tolerated, like any medication, it can cause side effects in some individuals. The most common side effects are related to its components:

1. Metformin SR (1000mg):

   • Gastrointestinal Issues: These may include nausea, vomiting, diarrhea, and abdominal discomfort. These side effects are typically temporary and may subside as the body adjusts to the medication.
   • Lactic Acidosis (Rare): This is a serious but rare side effect of Metformin, characterized by the buildup of lactic acid in the bloodstream. Symptoms include weakness, muscle pain, difficulty breathing, and dizziness. Lactic acidosis requires immediate medical attention.

2. Teneligliptin (20mg):

   • Common Side Effects: Some patients may experience headache, dizziness, or upper respiratory tract infections.
   • Hypoglycemia: Although Teneligliptin alone has a low risk of hypoglycemia, when combined with other anti-diabetic drugs, there is a slight increased risk of low blood sugar, particularly if the patient does not eat regularly or exercises excessively.

Other potential side effects include allergic reactions such as rash, itching, or swelling, and weight gain (although rare).

Precautions and Warnings

1. Kidney Function: Both Metformin and Teneligliptin are processed by the kidneys. Therefore, individuals with kidney disease should use TENELIGOLD M 1000 with caution. Regular monitoring of kidney function is recommended.
2. Liver Disease: Metformin should be used with caution in patients with liver disease, as it can exacerbate liver problems.
3. Pregnancy and Breastfeeding: The safety of TENELIGOLD M 1000 during pregnancy and breastfeeding has not been established, so it is advised to consult a healthcare provider before using this medication in these conditions.
4. Alcohol Consumption: Drinking alcohol in excess can increase the risk of lactic acidosis and other complications, so it should be avoided while taking TENELIGOLD M 1000.

Benefits of TENELIGOLD M 1000

1. Effective Blood Sugar Control: By combining the dual actions of Metformin SR and Teneligliptin, TENELIGOLD M 1000 offers robust blood sugar control throughout the day, addressing both insulin resistance and impaired insulin secretion.
2. Reduced Risk of Hypoglycemia: Teneligliptin's mechanism of action carries a low risk of causing hypoglycemia, even in combination with other anti-diabetic drugs.
3. Weight Neutrality: Unlike some other anti-diabetic medications, TENELIGOLD M 1000 does not cause weight gain and may be beneficial for overweight patients.
4. Convenience: The sustained-release formulation of Metformin SR allows for once-daily dosing, which is convenient for patients.

Conclusion

TENELIGOLD M 1000 is an effective combination therapy for managing type 2 diabetes mellitus. By combining the blood sugar-lowering effects of Metformin SR (1000mg) and Teneligliptin (20mg), this medication offers a comprehensive approach to managing glucose levels, addressing both insulin resistance and impaired insulin secretion.

While generally well-tolerated, it is essential for patients to follow their healthcare provider’s instructions and regularly monitor their blood sugar and kidney function. TENELIGOLD M 1000 not only helps control blood glucose but also provides additional benefits like weight neutrality and a reduced risk of hypoglycemia.

If you have type 2 diabetes, TENELIGOLD M 1000 may be an excellent option for you. However, always consult your doctor to ensure it is the right medication for your individual needs.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

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