PIRFENOID 400 (Pirfenidone (400mg)) : Uses, Dosage, Side Effects and more information...

PIRFENOID 400

Pirfenidone (400mg)

PIRFENOID 400 is a potent medication that contains Pirfenidone (400mg), widely recognized for its effectiveness in treating idiopathic pulmonary fibrosis (IPF). IPF is a chronic, progressive lung disease characterized by the thickening and scarring of lung tissues, which ultimately impairs breathing and reduces oxygen levels in the blood. By slowing the progression of IPF, PIRFENOID 400 helps improve patients' quality of life and prolong their survival. This article provides an in-depth look at PIRFENOID 400, including its uses, dosage, side effects, and precautions.

Uses of PIRFENOID 400

Primary Use: Idiopathic Pulmonary Fibrosis (IPF)

Pirfenidone is primarily used to treat idiopathic pulmonary fibrosis.  PIRFENOID 400 works by reducing the fibroblast proliferation, production of fibrosis-associated proteins, and inflammatory mediators, thereby slowing the disease progression.

Off-Label Uses

Although PIRFENOID 400 is primarily used for IPF, ongoing research is exploring its potential benefits in treating other fibrotic conditions, such as liver fibrosis and kidney fibrosis. However, these off-label uses should only be considered under the guidance of a healthcare professional.

Dosage and Administration of PIRFENOID 400

Recommended Dosage

The typical dosage regimen for PIRFENOID 400 involves a gradual increase to the full dose to minimize side effects. The standard recommended dosage is as follows:

• Days 1 to 7: One tablet (400mg) three times daily.
• Days 8 to 14: Two tablets (800mg) three times daily.
• From Day 15 onwards: Three tablets (1200mg) three times daily.

It is crucial to follow this titration schedule to allow the body to adjust to the medication and reduce the risk of side effects.

Administration Guidelines

• With Food: PIRFENOID 400 should be taken with food to reduce gastrointestinal discomfort, such as nausea and stomach upset.
• Regular Timing: Ensure to take the medication at the same times each day to maintain consistent blood levels.

Potential Side Effects of PIRFENOID 400

Common Side Effects

• Gastrointestinal Issues: Nausea, diarrhea, indigestion, and stomach pain are common side effects that usually subside over time.
• Skin Reactions: Rashes and photosensitivity are frequently reported. Patients are advised to use sunscreen and protective clothing when exposed to sunlight.
• Fatigue: Some patients may experience tiredness and fatigue.

Serious Side Effects

• Liver Dysfunction: Elevated liver enzymes may indicate liver damage.  Regular liver function tests are recommended.
• Severe Skin Reactions: In rare cases, serious skin reactions such as Stevens-Johnson syndrome may occur, requiring immediate medical attention.
• Allergic Reactions: Although rare, allergic reactions like hives, swelling of the face, lips, or throat, and difficulty breathing necessitate urgent medical care.

Drug Interactions of PIRFENOID 400

Interactions with Other Medications

• CYP1A2 Inhibitors: Medications such as fluvoxamine can increase pirfenidone levels in the blood, leading to enhanced side effects.
• CYP1A2 Inducers: Smoking induces CYP1A2, which can decrease the effectiveness of pirfenidone. Patients are advised to quit smoking while on PIRFENOID 400.

Food and Drink Interactions

• Alcohol: Limit alcohol consumption as it can increase the risk of liver damage.
• Caffeine: Be cautious with caffeine intake, as it can interfere with the metabolism of pirfenidone.

Precautions and Warnings for PIRFENOID 400

Liver Function Monitoring

Regular monitoring of liver function is essential before starting PIRFENOID 400 and periodically during treatment. Elevated liver enzymes can indicate potential liver damage, requiring dose adjustment or discontinuation of the medication.

Photosensitivity

Due to the risk of photosensitivity reactions, patients should avoid prolonged exposure to sunlight and use adequate sun protection measures, including sunscreen and protective clothing.

Pregnancy and Breastfeeding

The safety of PIRFENOID 400 during pregnancy and breastfeeding has not been established. Pirfenidone should only be used if the potential benefits justify the potential risks to the fetus or infant.

Renal Impairment

Patients with severe renal impairment should use PIRFENOID 400 with caution. Dose adjustment may be necessary, and regular monitoring of kidney function is recommended

How PIRFENOID 400 Works

Pirfenidone's therapeutic effects are believed to result from its antifibrotic and anti-inflammatory properties. It inhibits the synthesis of transforming growth factor-beta (TGF-β) and tumor necrosis factor-alpha (TNF-α), which are key mediators in the fibrotic process. By reducing the activity of these mediators, pirfenidone helps to slow down the scarring process in the lungs.

Clinical Efficacy

Clinical trials have demonstrated the efficacy of pirfenidone in slowing the progression of IPF. Studies have shown that patients taking pirfenidone experienced a slower decline in lung function compared to those taking a placebo. Additionally, pirfenidone has been associated with a reduction in the frequency of acute exacerbations of IPF, leading to improved survival rates.

Conclusion

PIRFENOID 400 (Pirfenidone 400mg) is a vital medication in the management of idiopathic pulmonary fibrosis. By slowing the progression of this debilitating disease, it helps improve patients' quality of life and prolongs their survival. While PIRFENOID 400 offers significant benefits, it is essential for patients to adhere to prescribed dosages, be aware of potential side effects, and attend regular medical check-ups to monitor their health. With proper use and medical guidance, PIRFENOID 400 can be an effective component of IPF treatment plans, offering hope and relief to those affected by this challenging condition. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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