PIRFENOID 400

PIRFENOID 400 is a prescription tablet containing pirfenidone (400 mg), marketed in India by Steris Healthcare Pvt. Ltd.

Pirfenidone is an antifibrotic (anti-scarring) medicine. Its precise mechanism is not completely understood, but research shows it reduces the activity of fibroblasts and the build-up of collagen, the substances that form scar tissue, and calms some of the inflammatory signals that drive fibrosis. In everyday language, it helps slow the process that makes lung tissue stiff.

It is used in adults with idiopathic pulmonary fibrosis. Because treatment is normally started at a low dose and increased gradually, the 400 mg strength is often used for maintenance dosing, where fewer tablets can make a multi-dose daily schedule simpler. Your pulmonologist will decide the exact schedule for you.

Product Information 

Why Is Pirfenidone Important?

1. It slows the pace of lung function decline: IPF steadily reduces lung capacity. In clinical trials, pirfenidone reduced the rate of decline in forced vital capacity (FVC), a key measure of lung function, compared with placebo. A slower decline can mean more months or years of comfortable breathing.

2. It helps protect daily independence: Walking to the market, climbing stairs, playing with grandchildren and managing household tasks all depend on lung capacity. Preserving it helps you stay independent longer.

3. It works through consistency: Pirfenidone is not a quick-relief medicine. Its value builds over months of regular use, which is why every dose counts and why uninterrupted supply matters.

4. It is part of a wider care plan: IPF management also includes pulmonary rehabilitation, oxygen therapy when needed, vaccinations and treatment of related problems such as acid reflux. Pirfenidone works best as one part of this full plan.

Key Benefits 

• Slows lung function decline: Helps reduce the yearly loss of FVC in people with IPF.
• Targets scarring: Acts on the fibrotic process itself, not just the symptoms.
• Fewer tablets per dose: The 400 mg strength can reduce pill burden during maintenance therapy, as directed by your doctor.
• Simple oral therapy: Taken by mouth at home, with no injections.
• Taken with food: Helps limit stomach upset and dizziness.
• Guideline-recognised: Pirfenidone is included in international IPF treatment guidelines and has been studied in multiple large trials.
• Supports long-term stability: Steady use can help some patients remain stable for longer.

Precautions: What You Should Know Before Using It

Share your complete medical history with your doctor before starting pirfenidone.

Do not use if

• You are allergic to pirfenidone or any ingredient in the tablet.
• You have previously had angioedema (swelling of the face, lips, tongue or throat) with pirfenidone.
• You are taking fluvoxamine, an antidepressant that strongly increases pirfenidone levels.
• You have severe liver impairment or end-stage kidney disease on dialysis.

Use with caution and medical supervision if

• You have mild to moderate liver problems. Liver function tests are needed before and during treatment.
• You have mild to moderate kidney impairment.
• You are pregnant, planning pregnancy or breastfeeding. Discuss benefits and risks with your doctor.
• You are elderly, as you may be more sensitive to side effects.
• You smoke. Smoking lowers pirfenidone levels and may reduce its effect. Quitting is strongly recommended.
• You take medicines that influence the CYP1A2 enzyme, such as ciprofloxacin, which may need a dose adjustment.

Possible Side Effects

Like all medicines, PIRFENOID 400 can cause side effects, although not everyone gets them. Many are mild to moderate and improve with food, time or a dose adjustment by your doctor.

Common side effects

• Nausea and vomiting
• Loss of appetite and weight loss
• Diarrhoea, indigestion or acid reflux
• Stomach discomfort or bloating
• Tiredness
• Dizziness
• Headache
• Trouble sleeping
• Skin rash or itching
• Sunburn-like skin reaction

Less common effects

• Joint pain
• Dry skin
• Changes in taste
• Worsening cough or breathlessness (these can also be IPF symptoms, so report them to your doctor)

Frequently Asked Questions

Where can I buy Pirfenidone 400 mg online?

Pirfenidone 400 mg can be purchased through licensed and authorized pharmacies or online medicine platforms, subject to prescription requirements and product availability.

What is the price of Pirfenidone 400 mg?

The price may vary depending on the brand, manufacturer, pack size, pharmacy, and applicable offers. Check the current listed price before ordering.

Can I order Pirfenidone 400 mg online?

Yes, Pirfenidone 400 mg may be ordered online through authorized pharmacies when a valid prescription and applicable purchasing requirements are fulfilled.

Is Pirfenidone 400 mg available from Steris Healthcare?

Availability depends on the current Steris Healthcare product range and stock. Check the relevant Steris Healthcare product listing or contact the company for current availability.

What is Pirfenidone 400 mg used for?

Pirfenidone is an antifibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF), a chronic lung disease associated with progressive scarring of lung tissue. It should be used under medical supervision.

What is the composition of Pirfenidone 400 mg?

The active ingredient is Pirfenidone 400 mg. The inactive ingredients may vary according to the manufacturer and specific formulation.

Is a prescription required?

Yes, Pirfenidone is a prescription medicine and should be used only under the supervision of a qualified healthcare professional.

How should Pirfenidone 400 mg be taken?

Take Pirfenidone 400 mg exactly as prescribed by your doctor. It is generally taken orally with food to help reduce gastrointestinal side effects. Swallow the tablet with water and do not change the dose or stop treatment without medical advice.

What should I know before buying Pirfenidone 400 mg?

Check the strength, formulation, pack size, manufacturer, expiry date, and authenticity before purchasing. Inform your doctor about liver or kidney problems, allergies, and all medicines, supplements, or herbal products you use. Medical monitoring may be recommended during treatment.

How can I order Pirfenidone 400 mg online?

Choose a licensed online pharmacy, verify the product details and current price, provide a valid prescription, and complete the pharmacy's ordering and payment process. Use Pirfenidone only according to your doctor's instructions.