Naproxen 250 mg + Domperidone SR 30 mg

Naproxzen D 250: Naproxen (250mg), Domperidone SR (30mg) – Comprehensive Guide

Naproxzen D 250 combines two active ingredients, naproxen (250mg) and domperidone SR (30mg), to provide effective relief for conditions associated with pain, inflammation, and gastrointestinal discomfort. The combination of these two agents helps manage a range of symptoms, especially those related to arthritis, musculoskeletal disorders, and gastrointestinal motility issues.

What is Naproxzen D 250?

Naproxzen D 250 is a combination medication containing two primary ingredients:

1. Naproxen (250mg): A nonsteroidal anti-inflammatory drug (NSAID) that works by reducing inflammation, pain, and fever.
2. Domperidone SR (30mg): A gastrointestinal motility agent that helps to relieve symptoms like nausea, vomiting, and gastroparesis, by increasing stomach motility and accelerating gastric emptying.

The SR in Domperidone SR stands for Sustained Release, meaning it is released slowly over time to provide a more consistent effect.

Key Features and Ingredients of Naproxzen D 250

1. Naproxen (250mg):

   • Anti-inflammatory Action: Naproxen works by inhibiting the production of prostaglandins, chemicals in the body that promote inflammation, pain, and fever. By reducing prostaglandin synthesis, naproxen helps to alleviate symptoms of pain and inflammation.
   • Pain Relief: Naproxen is effective in managing mild to moderate pain associated with conditions like arthritis, musculoskeletal pain, and dysmenorrhea (painful menstruation).
   • Fever Reduction: Naproxen also acts as an antipyretic, reducing fever in various inflammatory conditions.

2. Domperidone SR (30mg):

   • Gastrointestinal Motility: Domperidone SR promotes gastric motility, helping the stomach to empty more efficiently. It is particularly useful for individuals with gastroparesis, a condition in which the stomach empties too slowly.
   • Relief from Nausea and Vomiting: Domperidone SR helps to relieve nausea and vomiting caused by various conditions, including medication side effects and gastrointestinal disorders.
   • Sustained Release: The SR formulation ensures a gradual release of domperidone, providing prolonged relief without the need for frequent dosing.

Uses of Naproxzen D 250

1. Pain and Inflammation:

   • Naproxzen D 250 is primarily used to treat conditions that involve pain and inflammation, such as osteoarthritis, rheumatoid arthritis, musculoskeletal pain, back pain, and gout. The naproxen component works effectively to reduce both pain and swelling in the affected joints or muscles.

2. Dysmenorrhea:

   • Naproxzen D 250 can be used to alleviate menstrual cramps (dysmenorrhea) as the naproxen helps reduce pain and inflammation during menstruation.

3. Fever:

   • The anti-inflammatory and antipyretic properties of naproxen in Naproxzen D 250 help to reduce fever associated with infections or inflammatory conditions.

4. Gastrointestinal Disorders:

   • The domperidone SR (30mg) in Naproxzen D 250 is effective in treating symptoms related to nausea, vomiting, and gastroparesis. It can help speed up the process of stomach emptying, improving digestion and reducing discomfort from delayed gastric emptying.

5. Adjunct Therapy for Other Conditions:

   • Naproxzen D 250 can also be used as an adjunct therapy in individuals who are dealing with conditions that require both pain relief and improved gastric motility, such as post-surgery recovery or for those experiencing medication-induced nausea and discomfort.

How Does Naproxzen D 250 Work?

1. Naproxen:

   • Naproxen works by inhibiting the cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for producing prostaglandins—compounds that cause inflammation, pain, and fever. By blocking these enzymes, naproxen reduces pain, swelling, and fever in conditions such as arthritis, musculoskeletal injuries, and menstrual pain.

2. Domperidone SR:

   • Domperidone SR works by blocking dopamine receptors in the gastrointestinal tract and brain. By doing so, it helps to improve gastric motility, aiding in faster stomach emptying. Additionally, domperidone works in the vomiting center in the brain to reduce nausea and prevent vomiting, making it particularly effective for people experiencing nausea related to gastrointestinal issues or medication side effects.

Benefits of Naproxzen D 250

1. Effective Pain Relief:

   • Naproxzen D 250 offers effective pain relief for a variety of conditions, including arthritis, musculoskeletal pain, and menstrual cramps, helping individuals manage acute and chronic pain.

2. Reduction in Inflammation:

   • The anti-inflammatory properties of naproxen make it beneficial for reducing swelling and inflammation in conditions like osteoarthritis and rheumatoid arthritis, providing relief from stiffness and joint pain.

3. Gastrointestinal Benefits:

   • The domperidone SR component enhances gastric motility, making Naproxzen D 250 useful for managing nausea, vomiting, and gastroparesis. This combination improves overall digestive comfort and supports better gastric emptying.

4. Fever Reduction:

   • The antipyretic action of naproxen in Naproxzen D 250 helps reduce fever caused by inflammation or infections, aiding in overall symptom management.

5. Convenient Formulation:

   • The sustained-release form of domperidone in Naproxzen D 250 ensures consistent therapeutic levels over time, making it convenient for those who need long-lasting relief without frequent dosing.

How to Use Naproxzen D 250

• Dosage: The typical dosage of Naproxzen D 250 is one tablet taken once or twice a day, depending on the severity of symptoms and the doctor's recommendation. It is important to follow the prescribed dosage to minimize the risk of side effects.

• Administration: Take Naproxzen D 250 with food or milk to reduce the risk of gastric irritation. Swallow the tablet whole with a full glass of water. Do not crush or chew the tablet as it may affect the sustained-release action of domperidone.

• Duration: The duration of treatment with Naproxzen D 250 depends on the condition being treated and the doctor’s recommendations. It is usually used for short-term relief of acute symptoms, but for chronic conditions, a long-term treatment plan may be prescribed.

Possible Side Effects of Naproxzen D 250

Naproxzen D 250 may cause some side effects, especially when used for prolonged periods. These side effects can vary between individuals, but common ones include:

1. Gastrointestinal Issues:

   • Nausea, vomiting, abdominal pain, indigestion, or heartburn are possible due to the NSAID (naproxen) component.

2. Headache:

   • Some people may experience a headache while taking Naproxzen D 250.

3. Dizziness or Drowsiness:

   • The domperidone in Naproxzen D 250 may cause some dizziness or drowsiness, especially when taken in higher doses.

4. Allergic Reactions:

   • In rare cases, individuals may experience allergic reactions, such as skin rashes, swelling, or breathing difficulties. Seek medical attention if any of these symptoms occur.

5. Gastrointestinal Bleeding or Ulcers:

   • Long-term use of naproxen may increase the risk of gastrointestinal bleeding, ulcers, or perforation. It is important to take Naproxzen D 250 under medical supervision, especially for prolonged use.

6. Kidney or Liver Issues:

   • Prolonged use of naproxen may cause kidney or liver problems, and regular monitoring of liver and kidney function may be recommended.

Precautions and Warnings

• Kidney or Liver Problems: Use Naproxzen D 250 with caution if you have existing kidney or liver issues. Your doctor may monitor your kidney and liver function regularly.

• Pregnancy and Breastfeeding: The use of Naproxzen D 250 during pregnancy, especially in the third trimester, should be avoided due to the risk of premature closure of the fetal ductus arteriosus. Domperidone should also be used cautiously during breastfeeding, as it can pass into breast milk.

• Allergies to NSAIDs: If you have a known allergy to NSAIDs or have experienced gastric ulcers, it is important to avoid this medication and consult your doctor for alternatives.

FAQ Section

Q1: How long does it take for Naproxzen D 250 to start working?
Naproxzen D 250 starts providing relief within 1-2 hours of taking the medication, with the full effect becoming more noticeable after several hours due to the sustained-release action of domperidone.

Q2: Can I take Naproxzen D 250 with other medications?
Always consult your doctor before combining Naproxzen D 250 with other medications, especially other NSAIDs, blood thinners, or gastrointestinal medications, as there may be interactions.

Q3: Can Naproxzen D 250 be used for headaches?
Yes, Naproxzen D 250 can be used for headache relief due to the naproxen component, which helps reduce pain and inflammation.

Q4: Are there any long-term side effects of Naproxzen D 250?
Long-term use of Naproxzen D 250 may lead to gastric ulcers, bleeding, or kidney/liver issues. Regular monitoring by a healthcare provider is recommended for prolonged use.

Q5: Can I stop taking Naproxzen D 250 once I feel better?
It is important to follow your doctor’s instructions and continue taking Naproxzen D 250 for the prescribed duration to prevent symptom recurrence.

Conclusion

Naproxzen D 250 combines the power of naproxen for pain and inflammation relief with the domperidone SR for gastrointestinal motility and nausea relief. It provides an effective treatment for conditions like arthritis, musculoskeletal pain, menstrual cramps, and gastroparesis. Always follow your healthcare provider’s guidance to ensure the best results while minimizing potential side effects.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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