Mesalamine SR 800 mg

Mesalmile 800 ER: Mesalamine (800mg) – Comprehensive Guide

Mesalmile 800 ER is a medication that contains mesalamine (800mg) and is primarily used for the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease. The "ER" stands for Extended Release, which means the medication is designed to release slowly over time, ensuring that it has a sustained effect on the inflammation in the intestines.

What is Mesalmile 800 ER?

Mesalmile 800 ER contains mesalamine (800mg), a medication belonging to the 5-aminosalicylic acid (5-ASA) class. It is an anti-inflammatory drug that specifically works to reduce inflammation in the intestinal lining, particularly in patients with ulcerative colitis or Crohn's disease. Mesalamine helps in managing acute flare-ups and in maintaining remission of symptoms in chronic IBD.

The extended-release (ER) formulation allows for a gradual release of mesalamine into the digestive tract, ensuring effective treatment over a longer period of time and improving patient compliance.

Key Features and Ingredients of Mesalmile 800 ER

1. Mesalamine (800mg):

   • Anti-inflammatory Action: Mesalamine is a 5-ASA compound that works by directly targeting the affected areas in the intestines. It reduces inflammation, controlling symptoms such as diarrhea, abdominal pain, and rectal bleeding associated with ulcerative colitis and Crohn's disease.
   • Localized Action: Unlike systemic anti-inflammatory drugs, mesalamine acts locally at the site of inflammation, minimizing the risk of side effects throughout the body.

2. Extended Release (ER) Formulation:

   • The extended-release (ER) formulation of Mesalmile 800 ER ensures that the medication is released gradually into the intestines, providing continuous anti-inflammatory effects over a prolonged period. This steady release helps to maintain therapeutic drug levels and enhances the drug's effectiveness in treating chronic conditions.

3. Targeted Therapy for IBD:

   • The targeted delivery of Mesalmile 800 ER helps control inflammation specifically in the colon and small intestine, areas that are most affected in diseases like ulcerative colitis and Crohn's disease.

Uses of Mesalmile 800 ER

1. Ulcerative Colitis:

   • Mesalmile 800 ER is commonly used to treat and maintain remission in patients with ulcerative colitis, a condition that causes inflammation in the colon and rectum. The drug helps to control flare-ups, manage symptoms like bloody diarrhea, abdominal cramps, and rectal bleeding, and maintain remission after an initial response.

2. Crohn’s Disease:

   • Mesalmile 800 ER can also be used in the treatment of Crohn's disease, a type of IBD that causes inflammation in the digestive tract. It helps reduce inflammation in the intestines and manage the associated symptoms, such as abdominal pain, weight loss, and fatigue.

3. Maintenance Therapy:

   • After an initial treatment phase, Mesalmile 800 ER is often used for maintenance therapy to keep the disease in remission and reduce the risk of flare-ups. It is a long-term treatment option for patients with chronic IBD.

4. Post-Surgical Management:

   • Mesalmile 800 ER may also be used following surgery for IBD to help prevent the recurrence of inflammation and manage symptoms.

How Does Mesalmile 800 ER Work?

Mesalmile 800 ER works by delivering mesalamine directly to the areas of the intestines affected by ulcerative colitis or Crohn’s disease. Mesalamine has several mechanisms of action that help control inflammation:

1. Inhibition of Inflammatory Mediators:

   • Mesalamine inhibits the production of prostaglandins, leukotrienes, and other inflammatory mediators that contribute to the inflammatory response. By reducing these molecules, mesalamine helps to decrease swelling and irritation in the intestinal lining.

2. Local Action:

   • The extended-release (ER) formulation ensures that mesalamine is gradually released in the small intestine and colon, directly targeting the sites of inflammation. This localized action improves the drug's effectiveness while minimizing systemic side effects.

3. Reduction of Immune Response:

   • Mesalamine helps reduce the overactive immune response that leads to the inflammation seen in IBD. By controlling this immune reaction, mesalamine helps to manage symptoms and prevent further damage to the intestinal lining.

Benefits of Mesalmile 800 ER

1. Reduces Intestinal Inflammation:

   • Mesalmile 800 ER helps to reduce inflammation in the intestines, which is a key factor in managing symptoms of ulcerative colitis and Crohn’s disease. This leads to improvements in diarrhea, abdominal pain, rectal bleeding, and other related symptoms.

2. Prevents Disease Flare-Ups:

   • The extended-release formulation of Mesalmile 800 ER helps maintain steady therapeutic levels of mesalamine in the intestines, which can help to prevent future flare-ups and maintain long-term remission in patients with IBD.

3. Improves Quality of Life:

   • By reducing symptoms and helping to control inflammation, Mesalmile 800 ER significantly improves the overall quality of life for individuals with IBD. It allows patients to manage their condition more effectively and engage in daily activities with less discomfort.

4. Minimal Systemic Side Effects:

   • Since mesalamine acts locally at the site of inflammation, it tends to have fewer systemic side effects compared to other anti-inflammatory medications that affect the entire body. This makes Mesalmile 800 ER a safer option for long-term use.

How to Use Mesalmile 800 ER

• Dosage: The typical starting dose of Mesalmile 800 ER is 800mg once or twice daily, depending on the severity of the disease and the patient’s response. Your doctor will adjust the dose based on your individual condition.

• Administration: Mesalmile 800 ER should be taken by mouth with water, and it can be taken with or without food. Do not crush or chew the tablets, as this will affect the extended-release formulation.

• Duration of Use: Mesalmile 800 ER is often used as a long-term treatment for maintenance of IBD. It is important to follow your healthcare provider’s instructions regarding the length of treatment and not to stop taking the medication without consulting your doctor.

Side Effects of Mesalmile 800 ER

While Mesalmile 800 ER is generally well tolerated, it may cause some side effects. Common side effects include:

1. Headache:

   • Some patients may experience headaches while taking Mesalmile 800 ER.

2. Gastrointestinal Symptoms:

   • Mild nausea, diarrhea, flatulence, or stomach cramps may occur, especially during the initial phase of treatment.

3. Rash or Itching:

   • A skin rash or itching can develop in rare cases, which may be an allergic reaction.

4. Elevated Liver Enzymes:

   • Mesalamine can sometimes affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function may be recommended during long-term use.

5. Kidney Function:

   • Rarely, mesalamine may affect kidney function, so monitoring of kidney function is important, particularly in patients with preexisting kidney issues.

Precautions and Warnings

1. Kidney and Liver Function:

   • Mesalmile 800 ER should be used with caution in patients with kidney or liver conditions. Regular blood tests are recommended to monitor kidney and liver function during treatment.

2. Pregnancy and Breastfeeding:

   • Mesalmile 800 ER should be used during pregnancy only if the potential benefits outweigh the risks. It is also recommended to consult your healthcare provider before using mesalamine while breastfeeding.

3. Allergic Reactions:

   • In rare cases, mesalamine may cause severe allergic reactions such as rash, itching, or trouble breathing. If any of these symptoms occur, you should seek medical attention immediately.

4. Drug Interactions:

   • Mesalmile 800 ER may interact with other medications, particularly other anti-inflammatory drugs and immunosuppressants. Always inform your doctor about any medications or supplements you are taking to avoid potential interactions.

FAQ Section

Q1: How long does it take for Mesalmile 800 ER to work?
It may take several weeks for Mesalmile 800 ER to show significant effects in managing symptoms. Some relief might be experienced sooner, but the full benefits of the medication often require long-term use.

Q2: Can I take Mesalmile 800 ER with food?
Yes, Mesalmile 800 ER can be taken with or without food. However, do not chew or crush the tablet, as it will affect the extended-release action.

Q3: Can Mesalmile 800 ER be used for Crohn’s disease?
Yes, Mesalmile 800 ER is effective for managing inflammation and symptoms in patients with Crohn’s disease and ulcerative colitis.

Q4: Are there any long-term side effects of Mesalmile 800 ER?
Long-term use of Mesalmile 800 ER is generally well tolerated, but regular monitoring of kidney and liver function is recommended to detect any potential side effects.

Q5: Can I stop taking Mesalmile 800 ER if I feel better?
It is important to continue taking Mesalmile 800 ER as prescribed, even if you feel better. Always consult your doctor before stopping the medication to ensure that your condition is properly managed.

Conclusion

Mesalmile 800 ER (Mesalamine 800mg) is a highly effective treatment for managing ulcerative colitis, Crohn's disease, and other forms of inflammatory bowel disease. Its extended-release formulation allows for sustained, targeted action in the intestines, helping to reduce inflammation, control symptoms, and maintain remission. Always follow your healthcare provider’s instructions for the best results in managing your condition.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

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