Comprehensive Guide to Nintedanib 100 mg for Pulmonary Diseases

Lung disorders, including idiopathic pulmonary fibrosis (IPF) and certain interstitial lung diseases (ILDs), can significantly reduce quality of life if left untreated. Managing these conditions requires timely intervention and effective medications that can slow disease progression.

NINTEDONE 100, containing Nintedanib 100 mg, is an advanced pharmaceutical solution designed to help patients with pulmonary fibrosis and other fibrotic lung conditions. Manufactured by Steris Healthcare Pvt. Ltd., this medication works to reduce lung scarring, preserve lung function, and enhance patients’ quality of life.

With its proven efficacy and targeted mechanism, NINTEDONE 100 has become a trusted choice for healthcare providers managing chronic lung diseases.

What is Nintedanib 100 mg?

Nintedanib is a tyrosine kinase inhibitor that targets multiple pathways responsible for fibrosis and abnormal tissue remodeling in the lungs. By inhibiting key receptors involved in fibrotic processes, NINTEDONE 100 helps:

• Slow the progression of lung scarring

• Maintain lung function over time

• Improve patient outcomes in idiopathic pulmonary fibrosis and other progressive fibrosing ILDs

NINTEDONE 100 is indicated for adults diagnosed with IPF or progressive fibrosing interstitial lung diseases, offering a therapeutic option that can significantly impact disease trajectory.

Composition of NINTEDONE 100

Each capsule contains:

• Nintedanib 100 mg

This precise dosage is formulated to provide optimal efficacy while minimizing potential side effects, ensuring patient safety and therapeutic benefit.

How NINTEDONE 100 Works – Mechanism of Action

NINTEDONE 100 works by:

1. Inhibiting Tyrosine Kinase Receptors

   • Targets VEGF, FGF, and PDGF receptors involved in fibrotic tissue formation.

2. Reducing Fibrosis Progression

   • Limits abnormal tissue remodeling and lung scarring.

3. Preserving Lung Function

   • Slows decline in forced vital capacity (FVC), a key measure of lung health.

4. Improving Patient Quality of Life

   • Reduces the impact of shortness of breath, fatigue, and cough associated with progressive lung disease.

Uses of NINTEDONE 100

1. Idiopathic Pulmonary Fibrosis (IPF)

NINTEDONE 100 is primarily used to slow the progression of IPF, helping patients maintain lung function and reduce disease complications.

2. Progressive Fibrosing Interstitial Lung Diseases (ILDs)

For patients with other fibrosing ILDs showing progression, NINTEDONE 100 can:

• Reduce fibrosis development

• Maintain lung function

• Improve exercise tolerance and daily activity levels

3. Supportive Lung Care

In addition to disease-specific management, NINTEDONE 100 contributes to:

• Reducing shortness of breath

• Improving oxygen utilization

• Enhancing overall respiratory health

Benefits of NINTEDONE 100

• Slows Disease Progression: Reduces the rate of lung scarring and functional decline.

• Preserves Lung Capacity: Maintains FVC and supports long-term respiratory health.

• Improves Quality of Life: Reduces fatigue and breathing difficulties.

• Targeted Mechanism: Acts on multiple fibrotic pathways for effective disease management.

• Suitable for Long-Term Use: Can be administered under physician supervision for ongoing disease management.

Dosage and Administration

Recommended Adult Dosage

• Standard Dose: 100 mg capsules, taken twice daily (morning and evening)

• Administration: Swallow capsules whole with water, with or without food

• Consistency: Take at the same times each day to maintain steady drug levels

Dose Adjustments

• Dose adjustments may be required for patients with liver impairment or those experiencing side effects.

• Always follow the guidance of a pulmonologist or healthcare provider.

Side Effects of NINTEDONE 100

Common side effects include:

• Diarrhea

• Nausea or vomiting

• Abdominal pain or discomfort

• Fatigue

• Liver enzyme elevations (rare)

Important: Seek medical attention if experiencing severe diarrhea, jaundice, unexplained bruising, or severe nausea. Regular monitoring of liver function is recommended during therapy.

Precautions and Warnings

• Pregnancy & Breastfeeding: Not recommended; consult a physician if necessary.

• Liver Impairment: Dose may require adjustment and liver function should be monitored.

• Gastrointestinal Issues: Maintain hydration; report persistent diarrhea to your doctor.

• Medication Interactions: Inform your doctor about other drugs, especially anticoagulants, antifungals, or enzyme inhibitors.

• Regular Monitoring: Lung function tests and liver function tests are advised during treatment.

Lifestyle Tips to Complement NINTEDONE 100 Therapy

• Balanced Diet: Maintain nutrition to support immune and lung health.

• Hydration: Helps manage side effects like diarrhea.

• Exercise as Tolerated: Light physical activity can support lung capacity and overall well-being.

• Avoid Smoking and Pollutants: Protects lungs from further damage.

• Routine Checkups: Regular follow-ups with a pulmonologist ensure optimal treatment outcomes.

Who Should Use NINTEDONE 100?

• Adults diagnosed with idiopathic pulmonary fibrosis

• Patients with progressive fibrosing interstitial lung diseases

• Individuals seeking to slow lung scarring and maintain respiratory function

• Those under pulmonologist supervision for chronic lung management

Who Should Avoid NINTEDONE 100?

• Pregnant or breastfeeding women

• Patients with severe liver impairment

• Individuals allergic to nintedanib or excipients in the capsule

• Patients not under regular medical supervision

Drug Interactions

Patients should inform their doctor if they are taking:

• Anticoagulants (e.g., warfarin)

• Antifungal agents

• Enzyme inhibitors or inducers

• Other medications affecting liver metabolism

Interactions can affect drug levels and increase the risk of side effects.

Storage Instructions

• Store capsules at room temperature, below 30°C

• Protect from moisture and direct sunlight

• Keep out of reach of children

• Do not use after expiry date

Conclusion

NINTEDONE 100 (Nintedanib 100 mg) is an effective, targeted therapy for managing idiopathic pulmonary fibrosis and progressive fibrosing interstitial lung diseases. Its tyrosine kinase inhibitory action helps slow lung scarring, preserve lung function, and improve patient quality of life.

Frequently Asked Questions 

1. How long before NINTEDONE 100 shows effect?

• Nintedanib slows disease progression over months; consistent use is critical.

2. Can I take it with food?

• Yes, capsules can be taken with or without meals.

3. What if I miss a dose?

• Take the missed dose as soon as remembered unless it’s near the next scheduled dose.

4. Is long-term use safe?

• Yes, with regular monitoring of liver function and lung tests.

5. Can NINTEDONE 100 be combined with other medications?

• Only under doctor supervision; interactions can occur with anticoagulants and liver enzyme modifiers.