VOLANE SOURCE 450: A Comprehensive Guide to Valganciclovir Tablet IP 450 mg.........

Viral infections caused by cytomegalovirus (CMV) can be serious, especially in people with weakened immune systems. In India, CMV infections are commonly seen in organ transplant recipients, HIV/AIDS patients, cancer patients undergoing chemotherapy, and newborns with congenital infections. If left untreated, CMV can lead to severe complications affecting the eyes, lungs, liver, gastrointestinal tract, and even the brain.

VOLANE SOURCE 450 is an antiviral medicine containing Valganciclovir Tablet IP 450 mg, widely prescribed for the treatment and prevention of CMV infections. It is a trusted therapy used in hospitals and long-term care settings to protect high-risk patients from life-threatening viral complications.

By inhibiting viral replication, VOLANE SOURCE 450 helps control infection, reduce disease progression, and improve patient outcomes.

Composition of VOLANE SOURCE 450

Each film-coated tablet of VOLANE SOURCE 450 contains:

• Valganciclovir IP – 450 mg

Valganciclovir is a prodrug of ganciclovir, designed to offer better oral absorption and effectiveness.

What is Valganciclovir?

Valganciclovir is an antiviral medication belonging to the nucleoside analogue class. Once ingested, it is converted in the body into ganciclovir, the active form that fights viral infections.

It is primarily effective against:

• Cytomegalovirus (CMV)

• Certain herpes viruses in immunocompromised patients

Valganciclovir is preferred for oral therapy because it provides high bioavailability, making it suitable for long-term outpatient management.

How VOLANE SOURCE 450 Works

VOLANE SOURCE 450 works by inhibiting viral DNA synthesis, which stops the virus from multiplying. Its mechanism includes:

1. Conversion of valganciclovir into ganciclovir inside the body

2. Blocking viral DNA polymerase enzyme

3. Preventing replication of CMV within infected cells

4. Reducing viral load and disease progression

By controlling viral replication, VOLANE SOURCE 450 helps prevent organ damage and serious complications.

Uses of VOLANE SOURCE 450

1. Treatment of Cytomegalovirus (CMV) Retinitis

VOLANE SOURCE 450 is widely used to treat CMV retinitis, an eye infection that can cause vision loss or blindness, especially in:

• HIV/AIDS patients

• Organ transplant recipients

Early treatment helps preserve vision and prevent permanent eye damage.

2. CMV Prophylaxis After Organ Transplant

After kidney, liver, heart, or lung transplant, patients are at high risk of CMV infection due to immunosuppressive therapy. VOLANE SOURCE 450 is prescribed to:

• Prevent CMV disease

• Reduce transplant rejection risk

• Improve long-term graft survival

3. CMV Infection in Immunocompromised Patients

VOLANE SOURCE 450 is effective in managing CMV infections in patients with:

• HIV/AIDS

• Cancer receiving chemotherapy

• Long-term steroid therapy

4. Congenital CMV (Under Specialist Care)

In select cases, valganciclovir may be used under strict medical supervision for newborns with congenital CMV infection.

Benefits of VOLANE SOURCE 450

• Effective oral treatment for CMV infections

• Helps prevent CMV disease in transplant patients

• Reduces viral load and disease severity

• Convenient tablet form for long-term use

• Clinically proven antiviral efficacy

• Improves survival and quality of life in high-risk patients

Dosage and Administration

Recommended Dosage

Dosage depends on:

• Type of CMV infection

• Kidney function

• Patient’s immune status

Typical dosing includes:

• Induction dose for active CMV infection

• Maintenance dose for long-term suppression or prophylaxis

Dosage must always be decided by a doctor.

How to Take VOLANE SOURCE 450

• Take the tablet with food to improve absorption

• Swallow whole with water

• Take at the same time each day

• Do not crush or break the tablet

Missed Dose and Overdose

Missed Dose

• Take it as soon as you remember

• Skip the missed dose if it’s close to the next one

• Do not double the dose

Overdose

• May cause severe bone marrow suppression or kidney toxicity

• Seek immediate medical attention

Side Effects of VOLANE SOURCE 450

Common Side Effects

• Nausea or vomiting

• Diarrhea

• Headache

• Fatigue

Less Common Side Effects

• Low white blood cell count

• Low platelet count

• Anemia

• Fever

Serious Side Effects

• Bone marrow suppression

• Severe infections due to low immunity

• Kidney impairment

• Seizures (rare)

Regular blood tests are essential during treatment.

Precautions and Warnings

Before taking VOLANE SOURCE 450, inform your doctor if you have:

• Kidney disease

• Blood disorders

• History of low blood counts

• Liver problems

Pregnancy and Fertility Warning

• Valganciclovir may cause birth defects

• Not recommended during pregnancy

• Effective contraception is required during and after treatment

• Men should use contraception due to potential fertility effects

Breastfeeding

Breastfeeding should be avoided during therapy unless advised by a doctor.

Drug Interactions

VOLANE SOURCE 450 may interact with:

• Immunosuppressants

• Zidovudine and other antivirals

• Nephrotoxic medicines

• Bone marrow suppressing drugs

Always share your complete medication list with your doctor.

Who Should Avoid VOLANE SOURCE 450?

• Known allergy to valganciclovir or ganciclovir

• Severe neutropenia or thrombocytopenia

• Pregnancy unless benefits outweigh risks

Monitoring During Treatment

Patients on VOLANE SOURCE 450 require:

• Regular complete blood counts (CBC)

• Kidney function tests

• Liver function monitoring

• Eye examinations (for CMV retinitis)

Storage Instructions

• Store below 25°C

• Protect from moisture and light

• Keep tablets in original packaging

• Keep out of reach of children

Why Choose VOLANE SOURCE 450?

• Trusted antiviral therapy for CMV

• High oral bioavailability

• Suitable for long-term management

• Widely used in transplant and HIV care

• Clinically proven efficacy

Conclusion

VOLANE SOURCE 450, containing Valganciclovir Tablet IP 450 mg, is a critical antiviral medicine for managing and preventing cytomegalovirus infections in high-risk patients. Its effective viral suppression helps protect vital organs, preserve vision, and improve survival in immunocompromised individuals.

Frequently Asked Questions 

1. What is VOLANE SOURCE 450 used for?

It is used to treat and prevent cytomegalovirus (CMV) infections, especially in immunocompromised patients.

2. Is VOLANE SOURCE 450 safe for long-term use?

Yes, under strict medical supervision with regular monitoring.

3. Can VOLANE SOURCE 450 cure CMV infection completely?

It controls viral replication and prevents disease progression but may not completely eliminate the virus.

4. Does this medicine affect blood counts?

Yes, it may lower white blood cells and platelets. Regular blood tests are necessary.

5. Can I stop this medicine on my own?

No. Stopping treatment without medical advice may cause viral relapse.

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