VOLANE SOURCE 450

Cytomegalovirus (CMV) infection is a major concern, especially in patients with weakened immune systems such as organ transplant recipients, people living with HIV/AIDS, and patients on long-term immunosuppressive therapy. Valganciclovir Tablet IP 450 mg, marketed under the brand name VOLANE SOURCE 450, is a trusted antiviral medicine used worldwide for the treatment and prevention of CMV infections.

This article provides a detailed, SEO-friendly and user-friendly overview of VOLANE SOURCE 450, including its dosage, mechanism of action, uses, benefits, side effects, and information about Steris Pharma’s certification and medicine quality, followed by a clear conclusion.

What is VALGANCICLOVIR Tablet IP 450 mg (VOLANE SOURCE 450)?

Valganciclovir is an antiviral medication belonging to the nucleoside analogue class. It is a prodrug of ganciclovir, meaning it is converted into ganciclovir inside the body after oral administration. This conversion allows for better oral absorption compared to ganciclovir itself.

VOLANE SOURCE 450 contains Valganciclovir 450 mg per tablet and is commonly prescribed for:

• Treatment of CMV retinitis

• Prevention of CMV disease in solid organ transplant patients

• Management of CMV infections in immunocompromised individuals

Mechanism of Action – How VOLANE SOURCE 450 Works

The mechanism of action of valganciclovir is central to its effectiveness against CMV and other herpes viruses.

1. After oral intake, valganciclovir is rapidly converted into ganciclovir in the intestinal wall and liver.

2. Inside CMV-infected cells, ganciclovir is phosphorylated into its active form.

3. The active metabolite inhibits viral DNA polymerase.

4. This action prevents viral DNA replication, stopping the virus from multiplying.

5. As a result, viral load decreases and disease progression is controlled.

Because it targets viral replication directly, VOLANE SOURCE 450 is highly effective in controlling active CMV infection and preventing recurrence.

Uses of VALGANCICLOVIR Tablet IP 450 mg

VOLANE SOURCE 450 is prescribed for several important clinical conditions, including:

1. CMV Retinitis

Valganciclovir is widely used to treat CMV retinitis, a serious eye infection that can lead to vision loss if left untreated, particularly in patients with HIV/AIDS.

2. CMV Prophylaxis in Transplant Patients

One of the most common uses of Valganciclovir 450 mg tablets is the prevention of CMV disease in kidney, heart, liver, and other organ transplant recipients.

3. CMV Infection in Immunocompromised Patients

Patients receiving chemotherapy, long-term corticosteroids, or immunosuppressive drugs benefit from VOLANE SOURCE 450 to control CMV infection.

4. Other Herpes Virus Infections

In some cases, valganciclovir may be used under specialist supervision for severe infections caused by other herpes viruses.

Dosage and Administration of VOLANE SOURCE 450

Dosage of Valganciclovir Tablet IP 450 mg varies depending on the condition being treated, kidney function, and patient profile. Always follow the prescribing doctor’s instructions.

Common Dosage Guidelines (Adults)

• CMV Retinitis (Induction):
  900 mg twice daily (two 450 mg tablets) for 21 days.

• CMV Retinitis (Maintenance):
  900 mg once daily.

• CMV Prophylaxis (Transplant Patients):
  900 mg once daily, usually started within 10 days of transplantation and continued for up to 100–200 days, depending on risk.

Dose Adjustments

• Renal impairment: Dosage must be reduced based on creatinine clearance.

• Elderly patients: Careful monitoring is required.

• Pediatric use: Dose is calculated based on body surface area and kidney function.

 Important: VOLANE SOURCE 450 should be taken with food to improve absorption and reduce gastric discomfort.

Benefits of VOLANE SOURCE 450

Valganciclovir Tablet IP 450 mg offers several important benefits:

• High oral bioavailability compared to ganciclovir

• Effective CMV control in high-risk patients

• Reduces risk of CMV-related complications after organ transplant

• Prevents vision loss in CMV retinitis

• Convenient oral dosing, avoiding frequent IV therapy

• Clinically proven antiviral efficacy

Because of these advantages, VOLANE SOURCE 450 is a preferred choice for long-term CMV management.

Side Effects of VALGANCICLOVIR Tablet IP 450 mg

Like all antiviral medicines, VOLANE SOURCE 450 may cause side effects. Most are manageable with monitoring.

Common Side Effects

• Nausea and vomiting

• Diarrhea

• Abdominal pain

• Headache

• Fatigue

Hematological Side Effects

• Decreased white blood cells (leukopenia)

• Neutropenia

• Anemia

• Thrombocytopenia

Serious but Rare Side Effects

• Bone marrow suppression

• Severe infections due to low immunity

• Kidney function impairment

• Liver enzyme elevation

Precautions

• Regular blood counts and kidney function tests are essential.

• Avoid use during pregnancy unless absolutely necessary.

• Effective contraception is recommended during and after treatment.

Patients should immediately inform their doctor if they experience unusual bleeding, persistent fever, or extreme weakness.

Drug Interactions and Warnings

• Concomitant use with other myelosuppressive drugs may increase the risk of blood disorders.

• Caution with nephrotoxic drugs due to kidney clearance.

• Do not crush or break tablets; valganciclovir is potentially teratogenic.

Always disclose all medications to your healthcare provider before starting VOLANE SOURCE 450.

About Steris Pharma

Steris Pharma / Steris Healthcare is committed to delivering high-quality, safe, and effective pharmaceutical products. Medicines like VOLANE SOURCE 450 are manufactured and marketed following strict quality standards.

Quality & Certification Highlights

• WHO-GMP compliant manufacturing practices

• ISO-certified quality management systems

• Stringent raw material testing

• In-process quality checks at every production stage

• Finished product testing for purity, potency, and safety

Steris Pharma emphasizes regulatory compliance, pharmacovigilance, and consistent quality to ensure patient safety and therapeutic effectiveness.

Storage Instructions

• Store below 25°C in a dry place

• Protect from moisture and direct sunlight

• Keep out of reach of children

• Dispose of unused tablets as per medical guidance

Conclusion

Valganciclovir Tablet 450 mg is a highly effective antiviral medication for the treatment and prevention of cytomegalovirus infections, especially in immunocompromised and transplant patients. With its strong mechanism of action, reliable clinical outcomes, and convenient oral dosing, it plays a critical role in modern antiviral therapy.

When combined with Steris Pharma’s commitment to quality, GMP certification, and strict manufacturing standards, VOLANE SOURCE 450 stands as a dependable choice for healthcare professionals and patients alike.