Sevelamer 400 mg

sevelamer 400

Introduction 

SAVELINER 400 contains Sevelamer 400 mg, a phosphate-binding agent used in the treatment of hyperphosphatemia (high phosphate levels in the blood) commonly seen in patients with chronic kidney disease (CKD), especially those undergoing dialysis.Sevelamer works by binding to dietary phosphate in the gastrointestinal tract, thereby reducing its absorption into the bloodstream. This helps in controlling phosphate levels, which is crucial for maintaining bone health, cardiovascular function, and preventing complications in CKD patients.

Composition of SAVELINER 400

Each film-coated tablet of SAVELINER 400 contains:

• Sevelamer Carbonate – 400 mg

Form: Oral Tablet
Brand: SAVELINER 400
Manufacturer: Steris Healthcare Pvt. Ltd.

Sevelamer 400 Uses

The primary sevelamer 400 uses include:

• Treatment of Hyperphosphatemia in patients with chronic kidney disease (CKD) on hemodialysis or peritoneal dialysis

• Prevention of secondary hyperparathyroidism due to elevated phosphate levels

• Helps in reducing vascular calcification associated with prolonged high phosphate levels

• Improves cardiovascular outcomes in CKD patients

• Safe phosphate control without calcium load

How Sevelamer Works (Mechanism of Action)

Sevelamer carbonate is a non-absorbable, polymer-based phosphate binder. Once ingested, it binds to phosphate molecules in the gastrointestinal tract and forms an insoluble complex, which is then excreted in the feces.

Unlike calcium-based phosphate binders, sevelamer 400 does not increase calcium levels, which helps in avoiding hypercalcemia and related cardiovascular risks.

Clinical Efficacy and Benefits

Clinical studies show that sevelamer carbonate 400 mg:

• Significantly lowers serum phosphorus levels

• Decreases intact parathyroid hormone (iPTH) levels

• Reduces LDL cholesterol levels in CKD patients

• Controls calcium-phosphate product more effectively than calcium-based binders

• Helps prevent calcification of arteries and heart valves

Due to these benefits, sevelamer 400 is preferred by nephrologists worldwide.

Why Phosphate Control Matters in CKD Patients

Chronic kidney disease (CKD) reduces the kidney's ability to eliminate excess phosphate. This leads to hyperphosphatemia, a condition that:

• Promotes parathyroid hormone (PTH) secretion

• Weakens bones and leads to renal osteodystrophy

• Causes vascular calcification (stiffening of arteries)

• Increases cardiovascular risk (e.g., heart attack, stroke)

• Raises morbidity and mortality in dialysis patients

SAVELINER 400 helps maintain phosphate in the target range (3.5 to 5.5 mg/dL), reducing these life-threatening complications. 

Dosage and Administration – Tab Sevelamer 400 Dosage

• Initial Dose:

  • Typically 800 mg to 1600 mg (2–4 tablets) taken 3 times daily with meals.

• Titration:

  • Dose adjusted based on serum phosphate levels every 2–4 weeks.

Tablets should be swallowed whole. Do not crush, chew, or break.

Side Effects – Sevelamer 400 mg Tablet Side Effects

Most patients tolerate SAVELINER 400 well, but some may experience:

Common side effects:

• Nausea or vomiting

• Constipation

• Flatulence or bloating

• Abdominal pain

• Diarrhea

Rare side effects:

• Intestinal obstruction

• Fecal impaction

• Dyspepsia

Report any severe abdominal discomfort or persistent side effects to your physician.

Contraindications and Precautions

SAVELINER 400 (sevelamer carbonate tablets 400 mg) is contraindicated in:

• Patients with bowel obstruction

• Known hypersensitivity to sevelamer

• Swallowing disorders or severe gastrointestinal motility issues

Precautions:

• Monitor serum bicarbonate, calcium, and phosphate levels regularly

• Ensure adequate fluid intake to avoid constipation

• May decrease the absorption of fat-soluble vitamins (A, D, E, K) and folic acid

Drug Interactions

Sevelamer may interfere with the absorption of:

• Ciprofloxacin

• Mycophenolate mofetil

• Cyclosporine

• Tacrolimus

• Thyroid hormone (Levothyroxine)

To avoid interactions, other medications should be taken at least 1 hour before or 3 hours after sevelamer 400.

Patient Counseling Tips for SAVELINER 400

• Always take with meals – never on an empty stomach.

• Maintain hydration to reduce constipation risk.

• Follow up with regular phosphate and calcium tests.

• Report any GI symptoms, especially abdominal cramps or severe constipation.

• Take other medications separately (1 hour before or 3 hours after sevelamer).

• Do not chew or crush tablets – swallow whole.

Providing this guidance ensures better adherence and maximum effectiveness.

Packaging, Storage, and Availability

• Packaging: Alu-Alu or blister packs (10x10 or 10x1x10)

• Storage: Store below 25°C. Protect from moisture.

• Shelf life: 24 to 36 months from manufacturing date

• Availability: Pan-India supply via Steris Healthcare distributors

Custom branding/PCD franchise support also available for distributors and retailers.

Why Choose SAVELINER 400 from Steris Healthcare?

Steris Healthcare Pvt. Ltd. is one of India’s most trusted pharmaceutical manufacturers, known for its:

• WHO-GMP certified production facilities

• Adherence to stringent quality standards

• Affordable pricing without compromising on safety

• Fast distribution and pan-India availability

• Dedicated support for hospitals, nephrology clinics, and PCD franchise partners

With SAVELINER 400, Steris Healthcare ensures consistent phosphate control for better long-term outcomes in CKD patients.

FAQs – Frequently Asked Questions

Q1. What is Sevelamer 400 used for?

It is used to reduce high blood phosphate levels in patients with chronic kidney disease, especially those on dialysis.

Q2. How should I take sevelamer 400 mg tablet?

Take it with meals, usually 3 times a day, as directed by your doctor.

Q3. Is sevelamer better than calcium binders?

Yes. Sevelamer avoids the risk of hypercalcemia and vascular calcification seen with calcium-based phosphate binders.

Q4. Can I take sevelamer with other medications?

Some medicines may interact with sevelamer. Maintain a 1–3 hour gap as advised by your physician.

Q5. Is SAVELINER 400 safe for long-term use?

Yes, when taken under medical supervision, it is safe and effective for long-term phosphate management.

Conclusion – Why Sevelamer 400 is Essential for CKD Patients

Sevelamer 400, as present in SAVELINER 400, plays a crucial role in managing hyperphosphatemia in chronic kidney disease patients. By effectively binding and eliminating dietary phosphate, it helps maintain phosphate balance, prevents secondary hyperparathyroidism, and reduces the risk of vascular complications.Unlike calcium-based alternatives, sevelamer 400 offers phosphate control without increasing calcium levels, making it a safer and more effective option for long-term therapy.Choose SAVELINER 400 by Steris Healthcare – trusted by nephrologists, supported by science, and crafted for patient safety.