Mesalamine ER (400mg)

Digestive health disorders are increasingly affecting people across India due to changing dietary habits, stress, sedentary lifestyle, and rising autoimmune conditions. Among these, inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease are becoming more commonly diagnosed. These chronic conditions cause inflammation of the intestinal lining, leading to symptoms like abdominal pain, diarrhea, rectal bleeding, and fatigue, which significantly impact quality of life.

MESALMILE 400 is a trusted gastrointestinal medicine formulated with Mesalamine Extended Release (ER) 400 mg, designed to reduce inflammation in the intestines and help maintain remission in patients with inflammatory bowel disease. It is widely prescribed by gastroenterologists for both induction and maintenance therapy in mild to moderate ulcerative colitis.

Backed by consistent quality and clinical reliability, MESALMILE 400 Tablet plays a key role in long-term gut health management and symptom control.

What is Mesalamine ER 400 mg?

Mesalamine, also known as 5-Aminosalicylic Acid (5-ASA), is an anti-inflammatory agent that acts locally on the intestinal mucosa. It is considered a first-line therapy for ulcerative colitis and is also used in certain cases of Crohn’s disease affecting the colon.

The extended-release (ER) formulation of Mesalamine 400 mg ensures that the medicine is released gradually in the intestines, allowing sustained anti-inflammatory action where it is needed the most.

Key Characteristics of Mesalamine

• Acts locally in the gut

• Reduces inflammation without systemic steroid effects

• Suitable for long-term use

• Helps prevent disease relapse

Composition of MESALMILE 400

Each tablet contains:

• Mesalamine Extended Release – 400 mg

The ER formulation is designed to provide targeted delivery and prolonged therapeutic effect in the intestinal tract.

How MESALMILE 400 Works

The therapeutic action of MESALMILE 400 Tablet focuses on controlling intestinal inflammation.

Anti-inflammatory Action

Mesalamine inhibits the production of inflammatory mediators such as prostaglandins and leukotrienes in the intestinal lining.

Local Gut Protection

It acts directly on the inflamed mucosa of the colon, reducing redness, swelling, and ulceration.

Maintenance of Remission

Regular use helps keep ulcerative colitis in remission and prevents flare-ups.

Mucosal Healing

Supports healing of damaged intestinal lining and restores normal bowel function.

Uses of MESALMILE 400 Tablet

Mesalamine ER 400 mg uses are primarily related to inflammatory bowel diseases.

Ulcerative Colitis

• Mild to moderate active ulcerative colitis

• Maintenance of remission

• Prevention of disease flare-ups

Crohn’s Disease (Colonic Involvement)

• Adjunct therapy in mild cases

• Helps reduce colonic inflammation

Inflammatory Bowel Disease (IBD)

• Long-term management of chronic intestinal inflammation

• Symptom control and mucosal protection

Symptoms Controlled by MESALMILE 400

By reducing intestinal inflammation, MESALMILE 400 helps control:

• Chronic diarrhea

• Bloody stools

• Abdominal cramps

• Rectal pain

• Urgency and tenesmus

• Fatigue related to active disease

Benefits of MESALMILE 400

Regular use of MESALMILE 400 under medical supervision offers multiple benefits:

• Reduces intestinal inflammation

• Induces and maintains remission in ulcerative colitis

• Improves bowel regularity

• Reduces dependency on steroids

• Suitable for long-term therapy

• Well tolerated with minimal systemic side effects

• Improves overall quality of life

Why Extended-Release Mesalamine is Important

The ER formulation of Mesalamine provides significant advantages:

• Sustained drug release throughout the intestine

• Better symptom control

• Reduced dosing frequency

• Improved patient compliance

• Consistent anti-inflammatory effect

This makes MESALMILE 400 an effective and convenient option for chronic therapy.

MESALMILE 400 Dosage and Administration

General Dosage Guidelines

The dosage depends on disease severity and patient response.

• Mild to moderate ulcerative colitis: As prescribed by the gastroenterologist

• Maintenance therapy: Lower or adjusted dose as advised

How to Take MESALMILE 400

• Swallow the tablet whole with water

• Do not crush or chew

• Take at the same time every day

• Can be taken with or without food

Always follow the prescribed treatment schedule.

Side Effects of MESALMILE 400

MESALMILE 400 is generally well tolerated, but some patients may experience side effects.

Common Side Effects

• Nausea

• Abdominal pain

• Headache

• Flatulence

• Diarrhea

Less Common Side Effects

• Skin rash

• Fever

• Joint pain

Rare but Serious Side Effects

• Kidney function impairment

• Severe abdominal pain

• Blood disorders (very rare)

Regular monitoring helps ensure safety during long-term use.

Precautions and Warnings

Before starting MESALMILE 400, consider the following:

• Inform your doctor if you have kidney or liver disease

• Use cautiously in patients with known salicylate allergy

• Adequate hydration is recommended

• Periodic kidney function tests may be advised

• Pregnant and breastfeeding women should use only under medical advice

Do not discontinue treatment abruptly without consulting your doctor.

Drug Interactions

MESALMILE 400 may interact with:

• Other nephrotoxic drugs

• Certain immunosuppressants

• NSAIDs (use with caution)

Always inform your healthcare provider about all medicines you are taking.

MESALMILE 400 in Long-Term IBD Management

Inflammatory bowel disease requires long-term, consistent treatment. MESALMILE 400 plays a vital role by:

• Maintaining remission

• Reducing hospitalization risk

• Preventing complications

• Supporting normal daily activities

Adherence to therapy significantly improves long-term outcomes.

Diet and Lifestyle Advice with MESALMILE 400

Medication works best when combined with healthy lifestyle practices.

Dietary Tips

• Avoid trigger foods that worsen symptoms

• Limit spicy and processed foods

• Stay hydrated

• Follow a dietician-recommended IBD diet

Lifestyle Measures

• Manage stress

• Maintain regular follow-ups

• Avoid smoking

• Ensure adequate rest

Why Choose MESALMILE 400 from Steris Healthcare Pvt. Ltd.?

Steris Healthcare Pvt. Ltd. is committed to delivering high-quality, reliable, and patient-focused pharmaceutical products.

Key Reasons to Trust MESALMILE 400

• Manufactured under strict quality control standards

• Consistent extended-release formulation

• Clinically trusted by gastroenterologists

• Safe and effective for long-term use

• Focused on improving patient quality of life

Storage Instructions

• Store in a cool, dry place

• Protect from moisture and heat

• Keep out of reach of children

• Do not use after expiry date

Conclusion

MESALMILE 400 Tablet, formulated with Mesalamine Extended Release 400 mg, is a cornerstone therapy in the management of inflammatory bowel diseases, particularly ulcerative colitis. By delivering targeted, sustained anti-inflammatory action in the intestines, it helps control symptoms, promote mucosal healing, and maintain long-term remission.

Frequently Asked Questions 

What is MESALMILE 400 used for?

MESALMILE 400 is used to treat and maintain remission in ulcerative colitis and other inflammatory bowel diseases.

Is MESALMILE 400 a steroid?

No, it is a non-steroidal anti-inflammatory medicine that acts locally in the intestine.

Can MESALMILE 400 be taken long-term?

Yes, it is commonly prescribed for long-term maintenance therapy under medical supervision.

Does MESALMILE 400 cure ulcerative colitis?

It does not cure the disease but helps control inflammation and maintain remission.

Is MESALMILE 400 safe during pregnancy?

Use during pregnancy should be based on doctor’s advice after evaluating benefits and risks.

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