(10mg)Dapagliflozin , (500mg) SR Metformin

Introduction

GLIDAPAFLOZIN M 10/500 is a powerful oral antidiabetic medication combining two proven agents: Dapagliflozin 10 mg and Metformin 500 mg (Sustained Release). This fixed-dose combination is prescribed for effective glycemic control in adult patients with type 2 diabetes mellitus (T2DM), especially when monotherapy is insufficient.

Composition

• Dapagliflozin: 10 mg

• Metformin Hydrochloride (Sustained Release): 500 mg

What is GLIDAPAFLOZIN M 10/500?

GLIDAPAFLOZIN M 10/500 is a combination antidiabetic tablet formulated to improve blood glucose levels in adults with type 2 diabetes. It brings together the complementary mechanisms of Dapagliflozin, a SGLT2 inhibitor, and Metformin, a biguanide, for optimal glycemic control without significantly increasing the risk of hypoglycemia.

Uses of GLIDAPAFLOZIN M 10/500

• To manage blood sugar levels in adults with type 2 diabetes mellitus.

• As an adjunct to diet and exercise in patients whose diabetes is inadequately controlled on either drug alone.

• May reduce the risk of cardiovascular events in high-risk individuals.

• May aid in weight management and blood pressure reduction.

How Does GLIDAPAFLOZIN M 10/500 Work?

Dapagliflozin (10 mg)

• A Sodium-Glucose Co-Transporter-2 (SGLT2) inhibitor.

• Works by blocking glucose reabsorption in the kidneys.

• Promotes urinary glucose excretion, leading to lower blood glucose levels.

• Offers additional benefits like weight reduction and blood pressure control.

Metformin (500 mg SR)

• A biguanide that decreases hepatic glucose production and improves insulin sensitivity.

• Increases glucose uptake by muscles and reduces intestinal absorption.

• The Sustained Release (SR) formulation ensures better gastrointestinal tolerance and consistent blood levels.

Together, they act synergistically to provide powerful control over fasting and postprandial blood glucose levels.

Dosage and Administration

• Recommended Dose: One tablet once daily, preferably with food to minimize GI side effects.

• Dosage adjustment may be required based on renal function and clinical response.

• Do not crush or chew the sustained-release tablet.

• Renal function (eGFR) should be assessed before starting and periodically during therapy.

Side Effects of GLIDAPAFLOZIN M 10/500

Common Side Effects:

• Urinary tract infections

• Genital mycotic infections

• Polyuria or increased urination

• Nausea or diarrhea (due to Metformin)

• Headache

• Weight loss

Serious but Rare Side Effects:

• Lactic acidosis (Metformin-related; rare but life-threatening)

• Ketoacidosis (even with normal blood glucose)

• Dehydration and hypotension

• Renal impairment

• Hypoglycemia, especially when used with insulin or sulfonylureas

Precautions and Warnings

• Renal Impairment: Avoid in patients with eGFR < 45 mL/min/1.73 m².

• Liver Disease: Use with caution.

• Elderly Patients: Monitor for dehydration and renal function.

• Surgical Patients: Discontinue temporarily during surgical or radiological procedures involving iodinated contrast.

• Genital Hygiene: Encourage hygiene to reduce infection risk.

• Ketoacidosis: Monitor for signs even with normal blood glucose.

Drug Interactions

• Diuretics: May increase the risk of dehydration and hypotension.

• Insulin/Sulfonylureas: Increased risk of hypoglycemia.

• Alcohol: Increases the risk of lactic acidosis.

• Contrast agents: Risk of acute renal failure; temporarily discontinue Metformin before and after exposure.

Benefits of GLIDAPAFLOZIN M 10/500

• Dual mechanism ensures comprehensive glucose control.

• Low risk of hypoglycemia when not used with insulin.

• Aids in weight loss and cardiovascular protection.

• Improves patient compliance by reducing pill burden.

• Sustained release Metformin minimizes gastrointestinal discomfort.

Who Should Not Take GLIDAPAFLOZIN M 10/500?

• Patients with Type 1 Diabetes Mellitus

• Those with severe kidney impairment

• Individuals with a history of lactic acidosis

• Pregnant or breastfeeding women, unless clearly needed

• Patients with frequent urinary tract infections

Storage Information

• Store below 25°C, away from moisture and direct sunlight.

• Keep out of reach of children.

FAQs: GLIDAPAFLOZIN M 10/500

Q1. Can I take GLIDAPAFLOZIN M 10/500 with insulin?

Yes, but under strict medical supervision. The risk of hypoglycemia increases when used with insulin.

Q2. How long does it take to show results?

You may start seeing improvement in blood sugar within 1–2 weeks, but full benefits are usually evident in 4–8 weeks.

Q3. Does this tablet help with weight loss?

Yes, Dapagliflozin promotes glucose loss through urine, which can aid in modest weight reduction.

Q4. What should I do if I miss a dose?

Take it as soon as you remember. If it’s near the time of your next dose, skip the missed one. Do not double-dose.

Q5. Can I drink alcohol while taking this medicine?

Alcohol increases the risk of lactic acidosis with Metformin. Limit or avoid alcohol intake.

Conclusion

GLIDAPAFLOZIN M 10/500 is an effective, modern approach to managing type 2 diabetes with dual benefits from Dapagliflozin and Metformin SR. Its once-daily dosing, cardio-renal benefits, and weight control properties make it a preferred option for long-term diabetes management. Always follow your healthcare provider’s instructions and maintain a healthy lifestyle for best results.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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