Ulipristal Acetate 5mg– Uses, Dosage, Side Effects & Price

Introduction

ULIPSTALL 5 contains Ulipristal Acetate 5mg, a selective progesterone receptor modulator (SPRM) used primarily for the treatment of uterine fibroids in adult women of reproductive age. It helps reduce fibroid size, control heavy menstrual bleeding, and improve quality of life. Ulipristal acetate is also available in higher doses (30 mg) as an emergency contraceptive, but ULIPSTALL 5 is specifically formulated for fibroid management.

What is Ulipristal Acetate 5mg?

Ulipristal Acetate is a synthetic steroid that binds to progesterone receptors, blocking the effects of progesterone in the uterus. By doing so, it inhibits fibroid growth, reduces menstrual bleeding, and improves hemoglobin levels.

Uses of Ulipristal Acetate 5mg 

• Treatment of moderate to severe symptoms of uterine fibroids in women before menopause.

• Reduces fibroid size to relieve pelvic pain and discomfort.

• Controls excessive menstrual bleeding and anemia related to fibroids.

• May be prescribed before surgical procedures to shrink fibroids.

(Note: For emergency contraception, ulipristal acetate is given as a single 30 mg dose – not the 5 mg tablet.)

Mechanism of Action

Ulipristal Acetate modulates progesterone receptor activity, leading to:

• Inhibition of cell proliferation in fibroids.

• Induction of fibroid shrinkage.

• Regulation of menstrual cycles and reduction in bleeding volume.

Dosage and Administration

• Recommended dose: One ULIPSTALL 5 tablet daily, taken orally at the same time each day.

• Duration of treatment is usually up to 3 months per course, as prescribed by a doctor.

• Can be repeated after a treatment-free interval, based on medical advice.

• Swallow whole with water, with or without food.

Side Effects of Ulipristal Acetate Tablets

Common side effects:

• Headache

• Abdominal pain

• Nausea

• Mild breast tenderness

• Hot flashes

Less common but serious side effects:

• Liver function changes (rare but requires monitoring)

• Endometrial thickening (reversible after treatment)

Report persistent abdominal pain, yellowing of skin/eyes, or unusual fatigue to your doctor immediately.

Precautions Before Using

• Not recommended during pregnancy or while breastfeeding.

• Avoid if you have liver disease or unexplained vaginal bleeding.

• Inform your doctor about any hormonal treatments you are taking.

• Regular liver function tests may be required during treatment.

Drug Interactions – What drugs interact with Ulipristal Acetate?

• CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin) may reduce effectiveness.

• CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase drug levels.

• Hormonal contraceptives may reduce ulipristal’s action – use non-hormonal contraception during treatment.

• Herbal products like St. John’s Wort may decrease its efficacy.

Ulipristal Dose for Emergency Contraception

While ULIPSTALL 5 is used for fibroid treatment, emergency contraception requires a single 30 mg dose within 120 hours (5 days) of unprotected intercourse. This is a different product strength and should not be substituted with the 5 mg dose.

Ulipristal Tablet Price

The price of ULIPSTALL 5 may vary depending on location, distributor, and pack size. It is generally more cost-effective when purchased from reputed pharmaceutical companies like Steris Healthcare Pvt Ltd due to competitive pricing and quality assurance.

FAQs

Q1: Can ULIPSTALL 5 be used as a contraceptive?
No. ULIPSTALL 5 is meant for fibroid treatment, not contraception. For emergency contraception, a single 30 mg tablet is used.

Q2: How long does it take to see results?
Many women experience reduced bleeding within the first few weeks, but fibroid shrinkage may take 2–3 months.

Q3: Is liver monitoring necessary?
Yes, liver function tests are recommended during treatment to ensure safety.

Q4: Can it be taken with other hormonal medicines?
It’s best to avoid hormonal treatments during ulipristal therapy, as they can interfere with its action.

Q5: Will my fibroids grow back after stopping ULIPSTALL 5?
Fibroids may regrow over time, but treatment can be repeated as advised by your doctor.

Conclusion

ULIPSTALL 5 containing Ulipristal Acetate 5mg is a clinically proven treatment for moderate to severe uterine fibroid symptoms, offering significant relief from heavy bleeding, pelvic pain, and fibroid-related discomfort. With its targeted progesterone-blocking action, it improves quality of life and may delay or reduce the need for surgery. Always take under medical supervision with regular follow-up to ensure maximum benefits and safety.