SIROLIME 1 – Sirolimus 1mg Tablet Price, Uses, Benefits, Dosage, Side Effects & Complete Guide

Sirolimus is one of the most trusted immunosuppressant medicines used across India for organ transplant management. For patients undergoing kidney, liver, or heart transplant, maintaining a healthy immune balance is crucial. Your immune system naturally tries to attack anything foreign—including a transplanted organ. Sirolimus 1mg helps control this response, lowering the risk of rejection and improving long-term transplant survival.

SIROLIME 1, a Sirolimus 1mg tablet by Steris Healthcare, is designed to offer reliable, consistent, and high-quality immunosuppressant support for transplant patients who need long-term therapy. This comprehensive guide covers everything you need to know—Sirolimus 1mg tablet price in India, uses, mechanism, dosage, side effects, precautions, interactions, and more.

1. Introduction to SIROLIME 1 

SIROLIME 1 contains Sirolimus 1mg, an immunosuppressant medicine used widely in transplant care. It belongs to a class of drugs known as mTOR inhibitors (mammalian target of rapamycin inhibitors). By slowing down immune cell activity, SIROLIME 1 helps the body accept the transplanted organ and prevents episodes of rejection.

For many patients, Sirolimus becomes a long-term therapy—often taken for years after the transplant to ensure overall stability. Because of its strong immunosuppressive effect, it is usually prescribed together with other medicines like corticosteroids, tacrolimus, or cyclosporine, depending on the treatment plan.

Steris Healthcare focuses on delivering high-quality pharmaceutical products, ensuring safety, purity, and efficacy for patients who depend on chronic immunosuppressive medication.

2. SIROLIME 1 Price in India

One of the most searched queries by patients and caregivers is Sirolimus 1mg tablet price in India. The price varies depending on manufacturer, packaging, supply chain, and availability.

Average Price Range in India:

• ₹850 – ₹1,500 for a strip of 10 tablets
  (All prices are approximate and may vary by retailer, state, and brand.)

Imported or premium brands may cost more, while locally manufactured products like SIROLIME 1 offer quality at a more affordable price, especially for long-term use.

Why Prices Vary?

The cost depends on:

• Manufacturer’s quality standards

• Raw material purity

• Packaging

• Distribution channels

• GST and pharmacy margins

Patients taking Sirolimus typically need routine monitoring, so having a reliable and cost-effective brand makes long-term therapy easier.

3. What is Sirolimus 1mg Used For? 

SIROLIME 1 is mainly used as an immunosuppressant in transplant patients. Below are its key medical uses:

3.1 Preventing Organ Transplant Rejection

This is the primary medical use of Sirolimus 1mg.

Doctors prescribe SIROLIME 1 after:

• Kidney transplant

• Liver transplant

• Heart transplant

The immune system sees the new organ as foreign, triggering an attack. SIROLIME 1 reduces this immune activity and allows the transplanted organ to function normally.

3.2 Maintaining Long-Term Transplant Stability

Even after months or years of transplant, the body can still attempt rejection.
SIROLIME 1 helps maintain immune balance in the long term, securing the health of the transplanted organ.

3.3 Treatment of Lymphangioleiomyomatosis 

Sirolimus is used to treat LAM, a rare lung disease that affects women. It slows down abnormal cell growth in the lungs, improving lung function and reducing symptoms.

3.4 Certain Cancers and Autoimmune Diseases 

Doctors may use Sirolimus for:

• Some types of cancer

• Autoimmune disorders

• Severe inflammatory conditions

However, these are strictly specialist-prescribed uses.

4. How SIROLIME 1 Works 

Sirolimus works through a well-understood mechanism in the immune system:

1. Inhibits mTOR pathway – This stops immune cells (T and B cells) from multiplying.

2. Reduces inflammatory response – Prevents the immune system from attacking the transplanted organ.

3. Slows abnormal cell growth – Useful in conditions like LAM and some cancers.

4. Provides long-term immune suppression – Ensures the organ remains stable.

Its action is slower but more selective than older immunosuppressants, leading to better long-term outcomes in many patients.

5. Benefits of SIROLIME 1

5.1 Protects the Transplanted Organ

SIROLIME 1 provides reliable protection against organ rejection.

5.2 Allows Better Graft Longevity

Patients taking Sirolimus often experience improved long-term stability.

5.3 Lower Risk of Nephrotoxicity

Compared to other immunosuppressants, Sirolimus has a lower risk of kidney damage.

5.4 Useful in Multiple Treatment Plans

Can be combined with other medicines for:

• Enhanced immunosuppression

• Reduced doses of other drugs

• Balanced therapy with fewer side effects

5.5 Effective in LAM

Improves lung function and reduces cyst formation.

6. Dosage and Administration of SIROLIME 1

Always follow the exact dosage prescribed by your doctor.

Common Dosage Recommendations

• Usual starting dose: 1mg – 2mg daily

• Maintenance dose: 1mg daily or as advised

• Blood levels will be monitored regularly

Sirolimus has a narrow therapeutic range, meaning even small dose changes can impact blood levels and effectiveness.

How to Take SIROLIME 1

• Take at the same time every day.

• Swallow the tablet whole with water.

• Take consistently with or without food (do not switch frequently).

• Never miss a dose without informing your doctor.

Monitoring Required

Patients must undergo:

• Blood Sirolimus level test

• Kidney function test

• Liver test

• Lipid profile

• Complete blood count

7. Side Effects of Sirolimus 1mg Tablet

Like all immunosuppressant medicines, SIROLIME 1 may cause some side effects. These vary from mild to rare.

Common Side Effects

• Mouth ulcers

• Headache

• Diarrhoea

• Nausea

• Low immunity

• High cholesterol

• Acne

• High blood pressure

Moderate Side Effects

• Swelling in legs

• Anaemia

• Joint pain

• Hair loss or thinning

• Abdominal pain

Serious Side Effects (Rare)

• Infections due to low immunity

• Allergic reactions

• Breathing difficulty

• Slow wound healing

• Blood clotting issues

Immediate medical attention is required if you notice severe symptoms.

8. Precautions and Warnings Before Using SIROLIME 1

8.1 Avoid During Pregnancy

Sirolimus is not recommended for pregnant women.

8.2 Breastfeeding Warning

It may pass into breast milk. Avoid or consult a doctor.

8.3 Avoid Live Vaccines

Because immunity is low, avoid:

• MMR

• Varicella

• Yellow fever

8.4 Kidney & Liver Patients Must Be Monitored

Dose adjustments may be required.

8.5 Slower Wound Healing

Avoid surgeries unless necessary.

8.6 Interactions With Other Medicines

Sirolimus interacts with:

• Antibiotics

• Antifungals

• Anti-seizure drugs

• Blood pressure medicines

• Other immunosuppressants

Always inform your doctor about all medicines you are taking.

9. Drug Interactions of Sirolimus 1mg

Increases Sirolimus Levels

• Ketoconazole

• Erythromycin

• Verapamil

• Grapefruit juice

Decreases Sirolimus Levels

• Rifampicin

• Carbamazepine

• Phenytoin

Other Medicines to Use Carefully

• Cyclosporine

• Tacrolimus

Monitoring is essential during combination therapy.

10. Lifestyle and Dietary Advice for Patients on SIROLIME 1

Avoid Grapefruit

It increases Sirolimus levels dangerously.

Limit Alcohol

For liver safety.

Eat a heart-friendly diet

Since Sirolimus raises cholesterol, include:

• Fruits

• Vegetables

• Fish

• Salads

• Whole grains

Protect Against Infections

Use masks, avoid crowded places, maintain hygiene.

11. Why Choose SIROLIME 1 by Steris Healthcare?

Quality-Assured Manufacturing

Steris Healthcare follows stringent quality control standards.

Trustworthy Immunosuppressant for Chronic Use

Reliable for long-term transplant management.

Cost-Effective

Offers high quality at a competitive price.

Backed by Strong Medical Research

Formulated to provide consistent therapeutic action.

12. SIROLIME 1 – Price Summary

• Average Price Range (India): ₹850–₹1,500 per strip of 10 tablets

• Prices may vary based on location, pharmacy, and availability.

13. Conclusion

Sirolimus 1mg Tablet is an essential immunosuppressant that plays a critical role in transplant patient care. Its ability to reduce immune response, protect against organ rejection, and ensure long-term stability makes it one of the most important medications in transplant medicine.

14. FAQs – Sirolimus 1mg Tablet

1. What is Sirolimus 1mg used for?

It is mainly used to prevent organ transplant rejection and treat LAM.

2. What is the price of Sirolimus 1mg tablet?

Usually between ₹850–₹1,500 depending on the brand.

3. How long should Sirolimus be taken?

Most transplant patients require long-term use, often lifelong.

4. Can Sirolimus cause hair loss?

Yes, hair thinning may occur in some patients.

5. Can I stop taking Sirolimus suddenly?

No. Stopping can cause organ rejection.

6. How does Sirolimus work?

It suppresses immune cell growth by blocking the mTOR pathway.

7. Can I take Sirolimus on an empty stomach?

Yes, but always take it the same way every day for consistent blood levels.

8. Is Sirolimus safe?

Yes, when taken under medical supervision with regular monitoring.

9. Can I take vaccines while on Sirolimus?

Avoid live vaccines.

10. Can Sirolimus be used in children?

Only under specialist guidance.

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