Lamotrigine Dispersible 25 mg

Introduction

Lamotrigine dispersible 25 mg, available as dispersible tablets (such as LAMOTRIZ 25), is an anticonvulsant and mood stabilizer used in the treatment of epilepsy and bipolar disorder. The dispersible form can be chewed or dissolved in water, making it suitable for children and patients with difficulty swallowing.

Composition

• Brand Name: LAMOTRIZ 25

• Generic Name: Lamotrigine

• Strength: 25 mg per tablet

• Form: Dispersible tablet (can be chewed or mixed with water)

Mechanism of Action

Lamotrigine stabilizes neuronal membranes by inhibiting voltage-sensitive sodium channels, reducing the release of excitatory neurotransmitters like glutamate and aspartate. This action helps prevent seizures and stabilize mood, especially in bipolar disorder.

Uses of Lamotrigine 25 mg Tablet

In English

Lamotrigine 25 mg is used for:

1. Epilepsy

   • Focal (partial) seizures

   • Generalized tonic-clonic seizures

   • Lennox-Gastaut syndrome (a severe form of epilepsy in children)

2. Bipolar Disorder (Type I)

   • Maintenance therapy to delay episodes of mania or depression

3. Off-label Uses

   • Mood stabilization in treatment-resistant depression (as add-on)

   • Neuropathic pain (rare use)

In Hindi (लैमोट्रीजिन 25 एमजी टैबलेट के उपयोग)

लैमोट्रीजिन 25 मिलीग्राम टैबलेट का उपयोग निम्न स्थितियों में किया जाता है:

1. मिर्गी (Epilepsy)

   • आंशिक दौरे (Partial Seizures)

   • पूरे शरीर में फैलने वाले दौरे (Generalized Seizures)

   • लैनॉक्स-गास्टॉ सिंड्रोम (बच्चों में गंभीर मिर्गी)

2. बायपोलर डिसऑर्डर (Bipolar Disorder)

   • मूड के उतार-चढ़ाव को नियंत्रित करने के लिए

Dosage and Administration

• Initial Dose (for epilepsy or bipolar disorder):

  • Usually starts at 25 mg once daily

  • Increased gradually over weeks to avoid side effects

• Dispersible Use:

  • Can be chewed or dissolved in a small amount of water

Note: The dose may differ depending on whether the patient is taking other antiepileptic drugs (like valproate or carbamazepine).

Side Effects of Lamotrigine 25 mg

Common Side Effects:

• Headache

• Dizziness

• Nausea

• Blurred vision

• Sleep disturbances

• Fatigue

Serious Side Effects (Seek Immediate Medical Attention):

• Severe skin rash (Stevens-Johnson Syndrome)

• Fever, sore throat, swelling of lymph nodes

• Suicidal thoughts or mood changes

• Liver dysfunction (jaundice, dark urine)

• Coordination problems or tremors

Precautions and Warnings

• Skin reactions are more likely with high initial doses or rapid titration—always start low and go slow.

• Do not stop suddenly—may lead to seizure recurrence or mood destabilization.

• Pregnancy: Generally safe, but always consult your doctor.

• Breastfeeding: Passes into breast milk—monitor baby for side effects.

• Liver or kidney disease: Dose adjustment may be required.

Drug Interactions

Use with caution when combined with:

• Valproate (valproic acid) – increases lamotrigine levels (dose should be reduced)

• Carbamazepine, phenytoin – reduce lamotrigine levels (higher dose may be needed)

• Oral contraceptives – may reduce effectiveness of lamotrigine

• Sertraline, lithium – potential mood-stabilizing overlap

Storage Instructions

• Store below 25°C

• Protect from moisture and light

• Keep out of reach of children

Frequently Asked Questions (FAQs)

1. What is the use of Lamotrigine 25 mg?

Used to treat epilepsy and as a mood stabilizer in bipolar disorder.

2. Can Lamotrigine be used in children?

Yes, especially in the treatment of Lennox-Gastaut syndrome and other pediatric epilepsies.

3. How long does Lamotrigine take to work?

It may take several weeks to reach full effectiveness as the dose is gradually increased.

4. Can it cause skin rashes?

Yes. Rash can be mild or severe (life-threatening). Report any rash to your doctor immediately.

Conclusion

Lamotrigine 25 mg (LAMOTRIZ 25) is an effective medicine for epilepsy and bipolar disorder, especially useful in children due to its dispersible form. Start with a low dose and increase gradually to avoid serious side effects like skin rashes. Always use under medical supervision for safe and effective treatment.