Dextromethorphan Hydrobromide and Bupropion Hydrochloride Tablet – Uses, Dosage, Side Effects

Introduction to BUPROTROP DEXTER

BUPROTROP DEXTER is a combination medication containing Dextromethorphan Hydrobromide 45 mg and Bupropion Hydrochloride Extended Release 105 mg. This innovative dual-action formulation is primarily prescribed for the treatment of Major Depressive Disorder (MDD) in adults. It represents a novel approach to depression management by targeting multiple neurotransmitter systems to achieve better mood stabilization and symptom relief.

Composition

• Dextromethorphan Hydrobromide – 45 mg

• Bupropion Hydrochloride Extended Release – 105 mg

This combination works synergistically to modulate key brain chemicals involved in mood regulation.

What is Dextromethorphan Hydrobromide and Bupropion Hydrochloride Used For?

BUPROTROP DEXTER is primarily used in:

• Major Depressive Disorder (MDD)

• Treatment-resistant depression

• In some off-label uses, it may help in anxiety symptoms, though this is less established.

This fixed-dose combination is designed to provide quicker onset of antidepressant action and is usually considered when standard SSRI or SNRI therapy is insufficient.

Mechanism of Action

1. Dextromethorphan Hydrobromide:

• Acts as a non-competitive NMDA receptor antagonist

• Sigma-1 receptor agonist

• Reduces excessive glutamate activity and enhances neuroplasticity

2. Bupropion Hydrochloride ER:

• Inhibits reuptake of dopamine and norepinephrine

• Enhances mood, focus, and motivation

• Also inhibits CYP2D6, allowing dextromethorphan to remain active longer in the body

Together, these agents target both glutamatergic and monoaminergic pathways, providing a synergistic antidepressant effect.

How Does It Work?

• Dextromethorphan Hydrobromide is a sigma-1 receptor agonist and NMDA receptor antagonist. It modulates glutamate activity in the brain—playing a role in neuroplasticity and mood regulation.

• Bupropion Hydrochloride is a norepinephrine-dopamine reuptake inhibitor (NDRI). It enhances levels of these neurotransmitters to help alleviate depressive symptoms. It also slows the metabolism of dextromethorphan, increasing its effectiveness.

Together, this combination offers a rapid and sustained antidepressant effect with fewer sexual side effects than traditional antidepressants.

Dosage & Administration

• Usually taken once daily, preferably in the morning to reduce insomnia risk.

• Tablets should be swallowed whole and not crushed or chewed.

• Always follow doctor’s prescription; do not self-medicate or stop abruptly.

Side Effects of Dextromethorphan Hydrobromide and Bupropion Hydrochloride

Common side effects may include:

• Dizziness

• Dry mouth

• Nausea

• Increased blood pressure

• Anxiety or agitation

• Insomnia

• Headache

Serious side effects may include:

• Seizures (especially in those predisposed)

• Suicidal thoughts (especially at therapy initiation)

• Serotonin syndrome (rare, but serious)

If any side effects worsen or new symptoms appear, consult your doctor immediately.

Precautions Before Using BUPROTROP DEXTER

• Avoid alcohol due to increased risk of seizures.

• Not recommended in patients with a history of seizures, eating disorders, or abrupt alcohol/sedative withdrawal.

• Use cautiously in patients with high blood pressure.

• Avoid use during pregnancy or breastfeeding unless clearly needed.

• Do not combine with MAO inhibitors, SSRIs, or other serotonergic drugs without physician advice.

Drug Interactions

Drugs that may interact with BUPROTROP DEXTER include:

• MAO inhibitors (e.g., phenelzine, tranylcypromine)

• SSRIs/SNRIs (e.g., sertraline, fluoxetine)

• Antipsychotics (e.g., risperidone, olanzapine)

• CYP2D6 inhibitors (e.g., paroxetine, fluoxetine)

• Alcohol or sedatives – may increase side effects or risk of CNS depression

Always disclose all medications and supplements to your healthcare provider.

Advantages of BUPROTROP DEXTER

• Targets multiple neurotransmitter systems

• Faster onset of antidepressant action

• Lower risk of sexual dysfunction

• Option for treatment-resistant depression

Storage Instructions

• Store at room temperature (20°C to 25°C).

• Protect from light, moisture, and heat.

• Keep out of reach of children.

FAQs about Dextromethorphan Hydrobromide and Bupropion Hydrochloride

Q1: Is BUPROTROP DEXTER safe for long-term use?
Yes, when taken under medical supervision, it is considered safe for long-term treatment of depression.

Q2: Can this medication be used with SSRIs?
Usually not recommended due to the risk of serotonin syndrome. Always consult your physician.

Q3: Is there a risk of addiction?
No, this combination is not habit-forming.

Q4: When will I start feeling better after starting the medicine?
Some patients may begin to notice improvement in 1–2 weeks, but full effects may take up to 4–6 weeks.

Q5: Can this be used for anxiety?
While not FDA-approved for anxiety, some patients report reduced anxiety symptoms as a secondary benefit.

Why Choose BUPROTROP DEXTER from Steris Healthcare Pvt. Ltd?

• Manufactured in WHO-GMP certified facilities

• Complies with international quality standards

• Backed by advanced R&D and quality assurance

• Trusted by healthcare professionals across India

• Available through a reliable PCD pharma franchise model

Conclusion

BUPROTROP DEXTER, a fixed-dose combination of Dextromethorphan Hydrobromide 45 mg and Bupropion Hydrochloride ER 105 mg, represents a cutting-edge advancement in depression therapy. Backed by solid pharmacological rationale, fast action, and tolerability, it is especially beneficial for patients with major depressive disorder unresponsive to conventional antidepressants. Always use under the supervision of a qualified healthcare professional for best results.