Calcium Polystyrene Sulphonate Powder - Uses, Dosage, and Administration Guide

Calcium Polystyrene Sulphonate Powder

Calcium Polystyrene Sulphonate Powder, marketed as POLYSTERN SACHET, is a cation-exchange resin designed to treat hyperkalemia—a condition characterized by elevated potassium levels in the blood, which can lead to serious cardiac and muscular complications. This medication is primarily used in patients with chronic kidney disease, acute renal failure, and other conditions where potassium retention occurs. By effectively lowering potassium levels, it plays a critical role in preventing dangerous cardiac arrhythmias and systemic complications.

Chemical Composition and Formulations

The active component of POLYSTERN SACHET is Calcium Polystyrene Sulphonate, a sulfonated polystyrene resin in the calcium salt form. Chemically, it is a cross-linked polystyrene sulfonate resin with calcium ions. The resin appears as a cream to light brown fine powder with a characteristic vanilla odor. The molecular formula can be represented as (CH2CHC6H4SO3Ca)n, with an average potassium binding capacity of about 1.6 mmol per gram of resin. The powder is insoluble in water and is formulated as a powder for suspension in liquids prior to administration.

Mechanism of Action

Calcium Polystyrene Sulphonate Powder functions by exchanging calcium ions for potassium ions primarily in the large intestine. When administered orally, it passes through the stomach and small intestine, then in the colon, where potassium concentration is highest, calcium ions on the resin swap places with potassium ions in the gastrointestinal fluids. This ion exchange reduces potassium absorption into the bloodstream and promotes its excretion through feces, thereby lowering serum potassium levels.

Uses and Indications

The main indication for POLYSTERN SACHET is the treatment of hyperkalemia, especially in patients suffering from:

• Chronic kidney disease (CKD)

• Acute renal failure

• Addison’s disease

• Drug-induced potassium retention (such as with certain diuretics or ACE inhibitors)
  By reducing excess potassium, it helps prevent life-threatening cardiac disturbances such as arrhythmias and sudden cardiac arrest.

Dosage and Administration

The dosage of Calcium Polystyrene Sulphonate Powder depends on the severity of hyperkalemia and the patient’s overall condition. Typically, it is administered orally as a suspension with meals to enhance efficacy; rectal administration may be used in patients unable to take oral medication. The effectiveness depends on the time the resin remains in the gastrointestinal tract, and oral administration is usually preferred for continuous potassium removal. Medical supervision is essential to customize dosage and monitor potassium levels regularly.

Efficacy and Clinical Evidence

Clinical studies demonstrate that Calcium Polystyrene Sulphonate effectively reduces serum potassium levels. A recent study involving 107 patients showed that treatment with doses of 15 mg and 30 mg daily for one week led to a reduction in serum potassium by approximately 0.68 to 0.75 mmol/L. The treatment was well tolerated with a low incidence of adverse effects, indicating its safety and efficacy for short-term hyperkalemia management. This evidence supports the ongoing use of POLYSTERN SACHET in clinical practice.

Side Effects and Safety Profile

Common side effects include gastrointestinal symptoms such as constipation, nausea, vomiting, and loss of appetite. Rarely, it may cause severe complications like intestinal necrosis, especially when combined with sorbitol or used in patients with pre-existing bowel obstruction. Electrolyte imbalances such as hypocalcemia or hypomagnesemia may also occur. It is generally considered safe when used under medical supervision with close monitoring.

Contraindications and Precautions

POLYSTERN SACHET is contraindicated in patients with:

• Obstructive bowel disease

• Severe constipation or gastrointestinal motility disorders

• Hypocalcemia
  Precaution is advised in pregnant or breastfeeding patients due to lack of comprehensive safety data. Patients should be assessed for contraindications before initiating therapy.

Drug Interactions

This resin can interact with several orally administered drugs by binding them in the gut and reducing their absorption, potentially decreasing their efficacy. Notable drugs that may interact include lithium, thyroxine, and digitalis glycosides. To minimize interactions, it is recommended to separate the administration of Calcium Polystyrene Sulphonate Powder from other oral medications by at least three hours.

Warnings and Regulatory Status

Approved for medical use since 1958, Calcium Polystyrene Sulphonate Powder is recognized by regulatory agencies for hyperkalemia treatment. The FDA and other authorities have issued warnings regarding rare but serious gastrointestinal injuries associated with its use, especially when combined with sorbitol. Proper storage at room temperature and moisture protection is necessary to maintain drug stability.

Patient Advice and Tips

• Take POLYSTERN SACHET exactly as prescribed, usually with meals.

• Maintain adequate hydration and follow dietary potassium restrictions as advised.

• Report persistent gastrointestinal discomfort or allergic reactions immediately.

• Inform your healthcare provider about all concurrent medications to avoid interactions.

Cost and Availability

POLYSTERN SACHET is generally affordable and widely available through healthcare providers and pharmacies. Steris Healthcare Pvt Ltd is committed to ensuring broad access to this essential medication by maintaining competitive pricing and consistent supply across regions.

FAQs

• How does calcium polystyrene sulphonate work?
  It exchanges calcium ions for potassium ions in the gut, lowering blood potassium levels.

• Is POLYSTERN SACHET safe for long-term use?
  It is generally safe under medical supervision; however, long-term use requires monitoring for side effects and electrolyte balance.

• Can I take it with other medications?
  Separate dosing by at least three hours to prevent interactions.

Conclusion and Why Choose Steris Healthcare Pvt Ltd

Calcium Polystyrene Sulphonate Powder in the form of POLYSTERN SACHET is a trusted, effective treatment for hyperkalemia, backed by scientific evidence and long-standing clinical use. Its precise ion-exchange mechanism provides safe potassium reduction, critical for patients with renal and cardiac complications. Steris Healthcare Pvt Ltd ensures high-quality manufacturing standards, affordability, and reliable availability, making POLYSTERN SACHET a preferred choice for healthcare professionals and patients alike. Choose Steris Healthcare for dependable treatment with comprehensive patient support and stringent quality assurance.

By choosing POLYSTERN SACHET, you are opting for an effective solution rooted in decades of research to safely manage potassium levels and protect your health with a trusted brand in healthcare.
Calcium Polystyrene Sulphonate Powder remains an indispensable aid in maintaining electrolyte balance and safeguarding cardiac function.