BOSENTIME 125 : Enhance Breathing and Reduce PAH Symptoms

Introduction

BOSENTIME 125 is a prescription medication containing Bosentan 125 mg, a dual endothelin receptor antagonist used in the treatment of Pulmonary Arterial Hypertension (PAH). This condition involves abnormally high blood pressure in the arteries of the lungs, leading to breathlessness, fatigue, and heart complications. Bosentan improves exercise capacity, delays disease progression, and enhances quality of life in PAH patients.

Composition of BOSENTIME 125

Each film-coated tablet contains:

• Bosentan IP – 125 mg

• Excipients – q.s.

• Color – Approved color used

• Dosage Form – Oral, film-coated tablet

Indications & Uses

BOSENTIME 125 is indicated for:

• Treatment of Pulmonary Arterial Hypertension (PAH) in patients with WHO functional class II or III to:

  • Improve exercise tolerance

  • Delay clinical worsening

  • Enhance quality of life

• Prevention of new digital ulcers in patients with systemic sclerosis (in select cases)

Use only under medical supervision. This medication is part of a specialized PAH treatment protocol.

Mechanism of Action of Bosentan (125 mg)

Bosentan is a dual endothelin receptor antagonist that blocks the action of endothelin-1 (ET-1) on ETA and ETB receptors. Endothelin-1 is a potent vasoconstrictor and mitogen involved in the pathogenesis of PAH. By inhibiting these receptors:

• ETA receptor blockade reduces vasoconstriction and cell proliferation

• ETB receptor blockade reduces clearance of endothelin-1, leading to enhanced vasodilation

This action results in relaxation of pulmonary vessels, lower pulmonary vascular resistance, and reduced pulmonary arterial pressure, thus improving heart and lung function.

Dosage and Administration

Initial Dose:

• Start with Bosentan 62.5 mg twice daily for the first 4 weeks

Maintenance Dose:

• Increase to BOSENTIME 125 mg twice daily thereafter

Route: Oral
With/Without Food: Can be taken with or without meals
Duration: As prescribed by the physician based on response and tolerability

Regular liver function monitoring is mandatory during treatment.

Side Effects of BOSENTIME 125

Common Side Effects:

• Headache

• Flushing

• Nasal congestion

• Lower limb swelling (edema)

• Respiratory tract infections

• Low hemoglobin levels

Serious Side Effects:

• Liver function abnormalities (elevated ALT/AST)

• Anemia

• Hypotension

• Teratogenicity (serious birth defects if used in pregnancy)

Precautions & Warnings

• Hepatotoxicity: Perform liver function tests before starting and regularly during treatment.

• Pregnancy: Category X – contraindicated. Use dual contraception. Monthly pregnancy testing is advised.

• Hemoglobin Monitoring: Monitor for anemia, especially in the initial treatment phase.

• Women of Childbearing Potential: Must use reliable contraception throughout treatment and for 1 month after discontinuation.

• Not recommended in children under 12 years, unless specifically directed by a specialist.

Contraindications

• Known hypersensitivity to Bosentan or tablet components

• Moderate to severe liver impairment

• Elevated liver enzymes (>3x ULN)

• Use with cyclosporine A or glyburide

• Pregnancy

Drug Interactions

• Cyclosporine A – contraindicated; increases Bosentan plasma levels

• Rifampin – may reduce Bosentan efficacy

• Oral contraceptives – efficacy reduced; recommend additional non-hormonal contraception

• Warfarin – may alter INR; monitor coagulation

Monitoring Parameters

• Liver function tests (ALT, AST, bilirubin)

• Hemoglobin/hematocrit levels

• Pregnancy tests (monthly) in women of reproductive age

• Signs of fluid retention or hypotension

Storage Instructions

• Store at below 30°C, in a dry place

• Protect from light and moisture

• Keep out of reach of children

Frequently Asked Questions (FAQs)

Q1. What is BOSENTIME 125 used for?

A: BOSENTIME 125 is used to treat Pulmonary Arterial Hypertension (PAH), improving exercise capacity and slowing disease progression.

Q2. How long does BOSENTIME 125 take to work?

A: Benefits are typically seen within 4–8 weeks, but it must be taken regularly and under medical supervision for sustained improvement.

Q3. Can BOSENTIME 125 cause liver damage?

A: Yes, it may cause liver toxicity. Regular monitoring of liver function is required.

Q4. Is BOSENTIME 125 safe during pregnancy?

A: No. It is contraindicated in pregnancy due to high risk of birth defects.

Q5. What should I do if I miss a dose?

A: Take the missed dose as soon as you remember. If it's close to the next dose, skip the missed one. Do not double the dose.

Conclusion

BOSENTIME 125 (Bosentan 125 mg tablet) is a cornerstone therapy in the management of Pulmonary Arterial Hypertension, helping patients regain mobility and manage symptoms. However, due to potential risks including liver toxicity and teratogenicity, its use must be closely monitored by healthcare professionals. With proper administration, BOSENTIME 125 offers significant benefits in improving the long-term outlook for patients with PAH.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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