BOSENTIME 125 is a pharmaceutical product containing the active ingredient Bosentan at a dosage of 125 mg. Bosentan is a medication primarily used to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries of the lungs. This medication helps improve exercise capacity, reduce symptoms, and slow the progression of the disease. BOSENTIME 125 is designed to be part of a comprehensive treatment plan, which may include lifestyle changes and other medications, to manage PAH effectively and enhance the quality of life for patients.

Key Benefits:

1. Improves Exercise Capacity: BOSENTIME 125 enhances the ability of patients to perform physical activities, thereby improving overall stamina and endurance.
2. Reduces PAH Symptoms: It alleviates symptoms such as shortness of breath, fatigue, and chest pain associated with pulmonary arterial hypertension.
3. Slows Disease Progression: By managing blood pressure in the pulmonary arteries, Bosentan helps slow the progression of PAH.
4. Enhances Quality of Life: Regular use of BOSENTIME 125 can lead to significant improvements in the daily life and well-being of patients with PAH.
5. Comprehensive Treatment: It is often used in combination with other therapies for a more effective treatment plan.

How Does It Work?

Bosentan, the key ingredient in BOSENTIME 125, is an endothelin receptor antagonist. Endothelin is a naturally occurring peptide that constricts blood vessels and raises blood pressure. In patients with PAH, the levels of endothelin are abnormally high, leading to increased pulmonary arterial pressure. Bosentan blocks the endothelin receptors, preventing endothelin from exerting its vasoconstrictive effects. As a result, blood vessels relax and dilate, lowering the blood pressure in the lungs and improving blood flow. This mechanism helps reduce the workload on the heart and improves oxygen delivery throughout the body.

Directions for Use:

1. Dosage: The typical dosage is one 125 mg tablet taken twice daily, in the morning and evening.
2. Administration: Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
3. Timing: Take the medication at the same time each day to maintain consistent blood levels.
4. Compliance: Follow your healthcare provider's instructions precisely. Do not adjust the dose without consulting your doctor.

Side Effects:

Like all medications, BOSENTIME 125 may cause side effects. Common side effects include:

• Headache
• Flushing
• Nasal Congestion
• Edema (Swelling)
• Liver Function Changes: Regular monitoring of liver function tests is recommended.
• Anemia: Regular blood tests are necessary to check for low hemoglobin levels.
• Gastrointestinal Issues: Nausea, vomiting, and diarrhea may occur.

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