Vildagliptin 50 mg + Metformin Hydrochloride 850 mg

Introduction

VILDIABATE M 850 is an oral antidiabetic medication that combines Metformin (850mg) SR and Vildagliptin (50mg). It is used for the management of Type 2 Diabetes Mellitus (T2DM) to help regulate blood glucose levels effectively. This combination therapy works by improving insulin sensitivity, reducing glucose production in the liver, and stimulating insulin release in response to meals.

With the rising prevalence of diabetes, combination therapy has proven to be more effective in controlling blood sugar levels compared to monotherapy. VILDIABATE M 850 is prescribed when diet, exercise, and monotherapy with either Metformin or Vildagliptin alone fail to provide adequate glycemic control.

Key Ingredients and Their Role

1. Metformin (850mg) SR (Sustained Release)

Metformin is a biguanide class drug that plays a crucial role in managing diabetes by:

• Reducing glucose production in the liver (hepatic gluconeogenesis inhibition).

• Increasing insulin sensitivity and glucose uptake by muscles.

• Delaying glucose absorption from the intestines.

• Promoting weight loss by reducing appetite.

2. Vildagliptin (50mg)

Vildagliptin is a DPP-4 (Dipeptidyl Peptidase-4) inhibitor that helps in regulating blood sugar levels by:

• Enhancing insulin secretion from the pancreas in response to food intake.

• Reducing the release of glucagon (a hormone that increases blood glucose levels).

• Improving pancreatic beta-cell function for better insulin secretion.

The combination of Metformin SR and Vildagliptin provides a dual mechanism of action, ensuring better glycemic control while reducing the risk of hypoglycemia.

Uses of VILDIABATE M 850

VILDIABATE M 850 is primarily used for the management of Type 2 Diabetes Mellitus (T2DM), particularly when:

• Monotherapy with Metformin or Vildagliptin alone does not achieve desired blood sugar control.

• The patient requires a combination therapy to lower HbA1c levels effectively.

• A stable, long-term glucose management strategy is needed.

• The patient is overweight or obese and needs weight-neutral or weight-loss therapy.

Dosage and Administration

Recommended Dosage

• The usual dose of VILDIABATE M 850 is one tablet per day, preferably with meals to reduce gastrointestinal side effects.

• The dosage may be adjusted by a healthcare provider based on the patient’s blood sugar levels, tolerance, and kidney function.

• Maximum daily dosage should not exceed 100mg of Vildagliptin and 2000mg of Metformin.

How to Take

• Take the tablet whole with water, without crushing or chewing it.

• Consume it with meals to prevent gastric discomfort.

• Maintain a consistent schedule for better blood sugar control.

Side Effects

While VILDIABATE M 850 is well tolerated by most patients, some may experience mild to moderate side effects, including:

Common Side Effects:

• Nausea and vomiting

• Diarrhea or stomach discomfort

• Headache and dizziness

• Fatigue and weakness

• Hypoglycemia (especially when combined with other antidiabetic medications)

Serious but Rare Side Effects:

• Lactic acidosis (rare but serious complication due to Metformin accumulation, more likely in patients with kidney issues)

• Pancreatitis (associated with Vildagliptin, indicated by severe abdominal pain)

• Allergic reactions (rash, swelling, difficulty breathing)

• Liver function abnormalities

If any severe side effects occur, seek immediate medical attention.

Precautions and Warnings

Who Should Not Take VILDIABATE M 850?

• Patients with severe kidney disease or eGFR <30 mL/min/1.73m².

• Patients with liver disease or elevated liver enzymes.

• Individuals with a history of pancreatitis.

• People with a known allergy to Vildagliptin or Metformin.

• Those with a history of lactic acidosis.

• Pregnant and breastfeeding women should consult a doctor before using this medication.

Special Precautions

• Monitor kidney function regularly, as Metformin can accumulate and cause lactic acidosis in kidney-impaired patients.

• Check liver enzymes periodically since Vildagliptin may cause liver toxicity in rare cases.

• Avoid excessive alcohol consumption, as it increases the risk of lactic acidosis.

• Use cautiously in elderly patients due to the risk of renal impairment.

Drug Interactions

Certain medications may interact with VILDIABATE M 850, affecting its efficacy or increasing the risk of side effects. Inform your doctor if you are taking:

Medications That Increase Blood Sugar:

• Corticosteroids (e.g., prednisone)

• Diuretics (e.g., hydrochlorothiazide)

• Beta-blockers (e.g., propranolol)

Medications That Lower Blood Sugar:

• Sulfonylureas (e.g., glimepiride)

• Insulin

Other Interactions:

• Alcohol: Increases the risk of lactic acidosis.

• Iodine contrast agents: Used in imaging tests, can cause kidney dysfunction when combined with Metformin.

Benefits of VILDIABATE M 850

1. Effective Blood Sugar Control

• Targets multiple pathways involved in glucose regulation.

• Reduces both fasting and postprandial (after-meal) glucose levels.

2. Weight-Neutral or Weight-Loss Benefits

• Unlike insulin or sulfonylureas, this combination is unlikely to cause weight gain.

3. Low Risk of Hypoglycemia

• Since Metformin does not stimulate insulin release, the risk of dangerously low blood sugar is minimal.

4. Cardiovascular Benefits

• Some studies suggest that Metformin may reduce the risk of heart disease in diabetic patients.

5. Improved Beta-Cell Function

• Vildagliptin helps preserve pancreatic beta-cell function, ensuring long-term blood sugar control.

Lifestyle Modifications for Better Results

To achieve the best results with VILDIABATE M 850, follow these lifestyle changes:

• Healthy Diet: Eat a balanced diet rich in fiber, whole grains, lean proteins, and healthy fats.

• Regular Exercise: Engage in at least 150 minutes of moderate activity per week.

• Monitor Blood Sugar: Keep track of glucose levels regularly.

• Stay Hydrated: Drink sufficient water to support kidney function.

• Quit Smoking & Limit Alcohol: Both can worsen diabetes and increase complications.

Conclusion

VILDIABATE M 850 (Metformin 850mg SR + Vildagliptin 50mg) is an effective combination therapy for Type 2 Diabetes Mellitus. It enhances glycemic control, promotes weight management, and reduces the risk of hypoglycemia. When taken with a healthy lifestyle and regular monitoring, it significantly improves diabetes management and overall well-being.

Always consult a healthcare provider before starting this medication to ensure it suits your individual health needs.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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