Ursodeoxycholic Acid 300 mg

Liver and gallbladder disorders are increasingly common in India due to lifestyle changes, dietary patterns, and rising metabolic conditions. Conditions like gallstones, primary biliary cholangitis, and non-alcoholic fatty liver disease (NAFLD) can significantly impact quality of life if left untreated. Modern pharmacological therapy offers solutions that support liver function, improve bile flow, and prevent complications.

UDCHOLIC 300, containing Ursodeoxycholic Acid (UDCA) 300 mg, is a clinically proven medication used to treat liver and gallbladder disorders. It works by reducing cholesterol absorption in bile, improving bile flow, and protecting liver cells from damage, making it an effective therapeutic choice in hepatobiliary care.

This guide provides a complete overview of UDCHOLIC 300, including its composition, mechanism of action, uses, benefits, dosage, side effects, precautions, and frequently asked questions, making it a reliable resource for patients, caregivers, and healthcare professionals.

What is Ursodeoxycholic Acid 300 mg?

Ursodeoxycholic Acid (UDCA) is a naturally occurring bile acid used therapeutically to dissolve cholesterol-rich gallstones, improve bile flow, and protect liver cells from toxic bile acids.

Composition of UDCHOLIC 300

• Active Ingredient: Ursodeoxycholic Acid 300 mg

• Dosage Form: Oral tablet

UDCHOLIC 300 is formulated to ensure optimal absorption, consistent blood levels, and maximum therapeutic benefit. The 300 mg dosage is suitable for adults requiring standard treatment for gallstones, liver disorders, or biliary cholestasis.

How UDCHOLIC 300 Works (Mechanism of Action)

Ursodeoxycholic acid has several important mechanisms that make it effective in liver and gallbladder conditions:

1. Reduces Cholesterol Saturation in Bile
   UDCA decreases cholesterol absorption into bile, helping dissolve cholesterol-rich gallstones over time.

2. Protects Liver Cells
   UDCA stabilizes hepatocyte membranes and reduces the toxic effects of bile acids on liver cells.

3. Improves Bile Flow (Choleretic Effect)
   Promotes secretion of bile acids and reduces bile stagnation, preventing further liver damage.

4. Anti-inflammatory Effect
   Reduces inflammation in bile ducts and liver tissues, slowing disease progression in chronic liver conditions.

This multifaceted action makes UDCHOLIC 300 a highly effective therapeutic agent for hepatobiliary disorders.

Uses of UDCHOLIC 300

1. Gallstone Management

• Used to dissolve cholesterol-rich gallstones in patients who are not suitable for surgery

• Prevents the formation of new gallstones

2. Primary Biliary Cholangitis (PBC)

• Slows disease progression by reducing bile acid toxicity

• Improves liver function tests and reduces symptoms like fatigue and itching

3. Non-Alcoholic Fatty Liver Disease (NAFLD)

• Supports liver function in fatty liver disease

• Reduces liver enzyme levels and inflammation

4. Cholestasis in Pregnancy

• UDCA is prescribed to relieve itching and prevent complications in intrahepatic cholestasis of pregnancy

5. Other Liver Disorders

• Adjunct therapy in hepatitis

• Reduces risk of liver fibrosis in certain chronic liver diseases

Benefits of UDCHOLIC 300

1. Effective Gallstone Dissolution

UDCHOLIC 300 helps dissolve small, cholesterol-rich gallstones over several months, reducing the need for surgery in select cases.

2. Improved Liver Function

By stabilizing hepatocytes and improving bile flow, UDCHOLIC 300 enhances liver enzyme levels, supporting overall liver health.

3. Reduces Cholestasis Symptoms

It alleviates itching, jaundice, and discomfort associated with bile flow impairment.

4. Prevents Liver Damage

UDCA protects liver cells from toxic bile acids, reducing inflammation and slowing progression of chronic liver conditions.

5. Safe in Long-Term Use

Under medical supervision, UDCHOLIC 300 can be safely used for extended periods to manage liver and gallbladder disorders.

Dosage of UDCHOLIC 300

Recommended Adult Dosage

• Typical dose for adults: 10–15 mg/kg/day, divided into 1–2 doses

• UDCHOLIC 300 tablets make it easy to achieve the desired dose based on body weight

Pediatric Dosage

• Prescribed by a specialist based on body weight and condition

• Usually lower doses than adults

Administration Guidelines

• Take with meals to improve absorption

• Swallow the tablet whole; do not crush or chew

• Maintain a consistent schedule for best results

Missed Dose

• Take the missed dose as soon as remembered

• Skip if close to the next scheduled dose

• Do not double the dose

Side Effects of UDCHOLIC 300

Most patients tolerate UDCHOLIC 300 well, but side effects may occur in some individuals.

Common Side Effects

• Diarrhea or loose stools

• Mild stomach upset or nausea

• Abdominal discomfort

• Headache

Less Common Side Effects

• Dizziness

• Weight gain (rare)

• Itching (paradoxical in some cases)

Serious Side Effects

• Severe allergic reactions (rash, swelling, difficulty breathing)

• Liver enzyme elevation in rare cases

Patients experiencing serious side effects should seek immediate medical attention.

Precautions and Warnings

1. Liver Function Monitoring

• Regular monitoring of liver enzymes and bilirubin is recommended during treatment.

2. Pregnancy and Breastfeeding

• Generally considered safe in intrahepatic cholestasis of pregnancy, but always follow medical advice

• Use caution during breastfeeding; consult your doctor

3. Allergies

• Avoid if allergic to ursodeoxycholic acid or any tablet excipients

4. Interactions with Other Medications

• UDCA may interact with cholestyramine, aluminum hydroxide, or certain antibiotics

• Always inform your doctor about other medications

5. Pre-existing Conditions

• Dose adjustment may be required in patients with severe liver disease or kidney impairment

Drug Interactions

UDCHOLIC 300 may interact with:

• Cholestyramine – reduces absorption of UDCA

• Aluminum hydroxide or antacids – may affect drug absorption

• Other hepatoprotective medications – consult your doctor for dosing adjustments

Always inform your healthcare provider about all medications you take.

Why Choose UDCHOLIC 300?

• Clinically Proven: UDCA is well-studied and effective for gallstones and chronic liver diseases

• Improves Quality of Life: Reduces itching, discomfort, and liver-related symptoms

• Safe and Well-Tolerated: Suitable for long-term use under supervision

• Versatile Therapeutic Use: Effective in gallstone dissolution, PBC, NAFLD, and pregnancy-related cholestasis

• High-Quality Formulation: Ensures optimal absorption and consistent therapeutic effect

Storage Instructions

• Store at room temperature (15–30°C)

• Keep away from moisture, heat, and direct sunlight

• Keep out of reach of children

• Do not use expired medication

Conclusion

UDCHOLIC 300 (Ursodeoxycholic Acid 300 mg) is a highly effective medication for managing gallstones, liver disorders, and bile-related conditions. Its ability to dissolve cholesterol-rich gallstones, protect liver cells, and improve bile flow makes it a cornerstone in hepatobiliary therapy.

Frequently Asked Questions 

Q1. What is UDCHOLIC 300 used for?

It is used to treat gallstones, primary biliary cholangitis, non-alcoholic fatty liver disease, and pregnancy-related cholestasis.

Q2. How long does it take to dissolve gallstones?

Gallstone dissolution may take several months to a year, depending on stone size and composition.

Q3. Can UDCHOLIC 300 be used long-term?

Yes, under medical supervision, long-term use is generally safe for chronic liver conditions.

Q4. Can I take it during pregnancy?

It may be prescribed in intrahepatic cholestasis of pregnancy under strict medical supervision.

Q5. Are there dietary restrictions?

No strict restrictions, but a low-fat diet may complement treatment in gallstone disease.

Q6. Can children take UDCHOLIC 300?

Pediatric dosing should be determined by a specialist based on weight and condition.

Q7. Does UDCHOLIC 300 cause liver damage?

UDCA protects liver cells, but regular monitoring is recommended to detect any adverse effects early.

Q8. Can I drink alcohol while taking UDCHOLIC 300?

Alcohol may worsen liver function and should be avoided during treatment.