Trimetadizine SR 35mg````

Cardiovascular diseases continue to be a major public health concern in India, with chronic stable angina being one of the most common manifestations of coronary artery disease. Managing angina effectively requires therapies that not only reduce symptoms but also protect heart muscle cells from ischemic damage. Trimetazidine Hydrochloride Modified Release Tablets 35 mg, marketed under the brand name TRIMETAZ CR 35, is a well-established metabolic anti-anginal medicine widely prescribed by cardiologists for long-term heart care.

Unlike conventional anti-anginal drugs that mainly work by altering heart rate or blood pressure, trimetazidine hydrochloride focuses on improving the heart’s cellular energy metabolism. During ischemia, when oxygen supply to the heart is reduced, TRIMETAZ CR 35 helps cardiac cells utilize glucose more efficiently instead of fatty acids. This metabolic shift reduces oxygen demand, preserves cellular energy, and enhances myocardial function.

The controlled-release (CR) formulation ensures sustained and consistent drug levels throughout the day, offering prolonged protection against angina symptoms while improving patient compliance. TRIMETAZ CR 35 is often used as an add-on therapy in patients who continue to experience chest pain despite standard treatment, making it a valuable component of comprehensive cardiovascular management.

Uses of TRIMETAZ CR 35

 Trimetazidine hydrochloride modified release tablets is primarily used for the management of chronic ischemic heart conditions. It is not intended for immediate relief of chest pain but plays a crucial role in long-term symptom control.

Therapeutic Uses

1. Chronic Stable Angina

TRIMETAZ CR 35 is widely prescribed to reduce the frequency, intensity, and duration of angina attacks, helping patients lead a more active and comfortable life.

2. Adjunct Therapy in Coronary Artery Disease

It is commonly used alongside beta-blockers, calcium channel blockers, nitrates, and antiplatelet agents to enhance overall angina control without additional cardiovascular stress.

3. Ischemic Heart Disease

The medicine supports myocardial cell survival during ischemia by improving energy metabolism and reducing oxidative stress.

4. Microvascular Angina

TRIMETAZ CR 35 is beneficial for patients experiencing angina symptoms even when major coronary arteries appear normal.

5. Elderly Patients with Angina

Since it does not affect blood pressure or heart rate, it is particularly suitable for elderly patients who may not tolerate traditional therapies well.

Benefits of TRIMETAZ CR 35

1. Improves Cardiac Energy Metabolism

Trimetazidine optimizes myocardial metabolism by shifting energy production from fatty acid oxidation to glucose oxidation, which requires less oxygen.

2. Reduces Angina Frequency

Regular use significantly decreases the number of chest pain episodes, improving day-to-day comfort.

3. Enhances Exercise Tolerance

Patients experience improved stamina and reduced fatigue during physical activities.

4. Hemodynamically Neutral Action

TRIMETAZ CR 35 does not alter:

• Blood pressure

• Heart rate

• Cardiac contractility

This makes it safer for patients with borderline blood pressure or bradycardia.

5. Controlled Release for Sustained Effect

The CR formulation ensures steady plasma levels, offering prolonged protection with fewer daily doses.

6. Improves Quality of Life

Reduced angina symptoms allow patients to resume routine activities with confidence and comfort.

7. Well-Tolerated in Long-Term Use

The medicine has a favorable safety profile when used as prescribed.

Dosage of TRIMETAZ CR 35

Recommended Dosage

• Adults:
  One tablet of trimetazidine hydrochloride modified release tablets 35 mg, preferably taken with meals.

Special Populations

• Elderly Patients:
  Dose adjustment may be required, especially in patients above 75 years.

• Renal Impairment:
  Reduced dosing is advised in moderate kidney dysfunction.

Administration Guidelines

• Swallow the tablet whole with water

• Do not crush, chew, or break the tablet

• Take the medicine at the same time each day

Missed Dose

• Take the missed dose as soon as remembered

• Skip it if the next dose is due

• Do not double the dose

Dosage should always be determined by a qualified healthcare professional.

Side Effects of TRIMETAZ CR 35

Trimetazidine hydrochloride side effects is generally safe and well tolerated. However, some individuals may experience mild side effects.

Common Side Effects

• Nausea

• Vomiting

• Abdominal discomfort

• Headache

• Dizziness

• Fatigue

Uncommon Side Effects

• Skin rash

• Itching

• Sleep disturbances

Rare but Serious Side Effects

• Tremors

• Muscle stiffness

• Slowness of movement

• Restlessness

These symptoms resemble Parkinsonian disorders and are usually reversible upon stopping the medication.

Patients should seek medical attention if any unusual or persistent symptoms occur.

Warning and Precautions

Important Warnings

• Not suitable for treating acute angina attacks

• Discontinue immediately if movement-related symptoms appear

• Not recommended for patients with Parkinson’s disease or severe movement disorders

Precautions

• Use cautiously in elderly patients

• Monitor kidney function during long-term therapy

• Avoid excessive alcohol consumption

Pregnancy and Breastfeeding

• Use only if clearly prescribed by a doctor

• Safety data during pregnancy and lactation is limited

Driving and Operating Machinery

• May cause dizziness in some patients

• Avoid driving if affected

Always inform your doctor about existing health conditions and ongoing medications before starting TRIMETAZ CR 35.

Conclusion

Trimetazidine Hydrochloride Modified Release Tablets 35 mg (TRIMETAZ CR 35) represents a modern, metabolism-based approach to angina management. By protecting heart cells during ischemia and improving energy efficiency, it offers sustained symptom relief without compromising hemodynamic stability.

Its controlled-release formulation ensures consistent therapeutic benefits, better patient adherence, and improved quality of life. When used as part of a comprehensive cardiovascular treatment plan, TRIMETAZ CR 35 stands as a reliable and clinically proven option for patients with chronic stable angina and ischemic heart disease.

Frequently Asked Questions (F&Q)

Q1. What is TRIMETAZ CR 35 used for?

It is used for long-term management of chronic stable angina and ischemic heart disease.

Q2. Can TRIMETAZ CR 35 provide instant relief from chest pain?

No, it is not meant for immediate relief. It helps prevent future angina episodes.

Q3. How long should TRIMETAZ CR 35 be taken?

Duration depends on the patient’s condition and doctor’s recommendation.

Q4. Is TRIMETAZ CR 35 safe for elderly patients?

Yes, when prescribed appropriately and monitored regularly.

Q5. Can it be taken with other heart medications?

Yes, it is commonly used as an add-on therapy.

Q6. Does TRIMETAZ CR 35 lower blood pressure?

No, it does not affect blood pressure or heart rate.

Q7. What should I do if I experience tremors or stiffness?

Stop the medicine and consult your doctor immediately.