Temozolomide (100mg)-Uses, Side Effects, Dosage & More.....

May 04, 2024

Introduction

TMOZOLMIDE 100 contains Temozolomide 100mg, an oral chemotherapy drug used in the treatment of brain tumors, especially glioblastoma multiforme (GBM) and anaplastic astrocytoma. As an alkylating agent, it works by damaging the DNA of cancer cells, slowing or stopping their growth and division.Temozolomide is recognized for its ability to cross the blood-brain barrier, making it highly effective in treating central nervous system tumors.

Key Features and Composition

Brand Name: TMOZOLMIDE 100
Active Ingredient: Temozolomide (100mg)
Drug Class: Alkylating Agent (Antineoplastic)
Dosage Form: Oral Capsule
Packaging: Blister strips in moisture-resistant packs
Manufactured in: WHO-GMP compliant facility

Usage and Indications

TMOZOLMIDE 100 is indicated for the treatment of:

Glioblastoma Multiforme (GBM) – newly diagnosed or recurrent
Anaplastic Astrocytoma – a type of high-grade glioma
Sometimes used in off-label indications under oncologist guidance

Administration:

Usually taken once daily, with or without food
Dosing cycles may vary (e.g., 5 days on, 23 days off) depending on the treatment protocol

Benefits of TMOZOLMIDE 100

Oral chemotherapy – avoids hospital IV sessions
Crosses blood-brain barrier – effective for brain cancers
Proven to prolong survival in combination with radiation therapy
Well-established safety profile when used under medical supervision

How Temozolomide Works

Temozolomide interferes with DNA replication by adding methyl groups to DNA strands of cancer cells. This leads to cell cycle arrest and ultimately cell death, especially in rapidly dividing tumor cells. Its ability to penetrate the brain makes it ideal for gliomas.

Precautions and Side Effects

Important Precautions:

Blood count monitoring is essential (WBCs, platelets)
Avoid during pregnancy and breastfeeding
Use under strict oncological supervision

Common Side Effects:

Nausea and vomiting
Fatigue
Loss of appetite
Headache
Constipation
Bone marrow suppression (low blood counts)

Storage Instructions

Store below 25°C, in a dry place
Keep in original packaging to avoid moisture exposure
Keep out of reach of children

Frequently Asked Questions (FAQs)

1. What is TMOZOLMIDE 100 used for?
It is used to treat brain cancers such as glioblastoma multiforme and anaplastic astrocytoma.

2. How should Temozolomide be taken?
As prescribed by your oncologist, usually once daily in treatment cycles. Swallow the capsule whole with water.

3. Are there any serious side effects?
Yes, including low blood counts, which may lead to infections or bleeding. Regular blood tests are required.

4. Can it be taken at home?
Yes, it is an oral chemotherapy drug and is commonly administered at home under medical supervision.

5. Is it safe in pregnancy?
No. Temozolomide is contraindicated during pregnancy and should only be used with proper contraception.

Conclusion

TMOZOLMIDE 100 (Temozolomide 100mg) is a vital oral chemotherapy option for patients battling aggressive brain tumors like glioblastoma. Its ability to penetrate the central nervous system and its convenience as an oral formulation make it a preferred choice in modern oncology. Always follow your oncologist’s guidance for safe and effective treatment.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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