TMOZOLMIDE 100

Temozolomide 100 mg Capsules contain Temozolomide, an oral chemotherapy medicine used in the treatment of certain types of brain tumors. It belongs to a class of medicines known as alkylating agents, which work by damaging the DNA of cancer cells and reducing their ability to grow and divide. Temozolomide 100 mg is a prescription chemotherapy capsule used in the treatment of certain brain tumors, including glioblastoma multiforme and anaplastic astrocytoma, as prescribed by an oncologist.

Temozolomide is commonly prescribed as part of a comprehensive cancer treatment plan under the supervision of a qualified oncologist. The treatment schedule, dosage, and duration depend on the type of cancer, previous therapies, and the patient's overall health.

Because this medicine affects rapidly dividing cells, careful monitoring through regular blood tests and clinical assessments is typically required during treatment.

Composition

Each capsule contains:

• Temozolomide IP 100 mg

Inactive ingredients may vary depending on the manufacturer.

Uses of temozolomide 100mg

Temozolomide is prescribed for specific cancers based on the treating physician's assessment. Common indications include:

• Newly diagnosed glioblastoma when used in combination with radiotherapy, followed by maintenance treatment.
• Certain recurrent or progressive malignant gliomas when other treatment options are not suitable or have not been effective.

The decision to use temozolomide depends on several factors, including the patient's diagnosis, medical history, laboratory findings, and treatment goals.

How temozolomide 100mg Works

Temozolomide is an alkylating chemotherapy agent. After being absorbed into the body, it converts into an active compound that attaches alkyl groups to the DNA of rapidly dividing cells. This interferes with DNA replication and repair, reducing the ability of cancer cells to survive and multiply.

Because healthy cells can also be affected, treatment may lead to side effects that require regular monitoring by healthcare professionals.

General Dosage Information

Temozolomide should be taken only as prescribed by an oncologist or another qualified healthcare professional.

General administration guidance includes:

• Swallow the capsule whole with water.
• Do not crush, chew, or open the capsule.
• It may be taken on an empty stomach or as advised by your healthcare provider.
• Take the medicine at approximately the same time each day if prescribed on a daily schedule.
• If vomiting occurs after taking a dose, do not take an extra capsule unless instructed by your doctor.
• Never adjust the dose or stop treatment without medical advice.

Dosage is individualized according to body surface area, blood counts, treatment protocol, and clinical response.

Possible Side Effects

Like all chemotherapy medicines, temozolomide may cause side effects. Not everyone experiences them, and their severity varies among individuals.

Common side effects may include:

• Nausea
• Vomiting
• Fatigue
• Loss of appetite
• Constipation
• Headache
• Hair thinning or hair loss
• Weakness

More serious adverse effects can include:

• Low white blood cell count
• Low platelet count
• Anemia
• Increased risk of infection
• Fever
• Unusual bleeding or bruising
• Liver function abnormalities

Seek immediate medical attention if symptoms such as persistent fever, severe bleeding, difficulty breathing, or signs of an allergic reaction occur.

Warnings and Precautions

Before starting Temozolomide, inform your healthcare provider if you

• Have liver disease
• Have kidney disease
• Have a weakened immune system
• Have a history of allergic reactions to chemotherapy medicines
• Are pregnant or planning pregnancy
• Are breastfeeding

Women should avoid becoming pregnant during treatment. Men receiving Temozolomide may also be advised to use effective contraception for a specified period after treatment because the medicine may affect fertility and fetal development.

Routine blood tests are generally required to monitor blood cell counts and overall treatment safety.

Drug Interactions

Temozolomide may interact with certain medicines, including:

• Other chemotherapy drugs
• Medicines that suppress bone marrow function
• Immunosuppressive medications
• Certain vaccines

Always provide your healthcare professional with a complete list of prescription medicines, over-the-counter products, vitamins, and herbal supplements before starting treatment.

Storage Instructions

Store the capsules:

• At room temperature.
• Away from moisture and direct sunlight.
• In the original packaging until use.
• Out of the reach of children and pets.

Do not use the medicine after its expiry date.

Prescription Requirement

Temozolomide is a prescription-only medicine in India and should be used only under the supervision of a qualified medical practitioner experienced in cancer treatment. It should not be self-medicated or shared with others.

Frequently Asked Questions

1. What is temozolomide 100mg used for?

Temozolomide 100 mg is prescribed for the treatment of certain brain tumors, including glioblastoma and some recurrent malignant gliomas, as determined by an oncologist.

2. Is temozolomide 100 mg a chemotherapy medicine?

Yes. Temozolomide is an oral chemotherapy medicine belonging to the alkylating agent class.

3. How should I take Temozolomide capsules?

Take the capsules exactly as prescribed by your healthcare provider. Swallow them whole with water and do not crush or open them.

4. Can temozolomide be taken with food?

Your doctor will advise the most appropriate way to take the medicine. Many patients are instructed to take it consistently, with or without food, according to their treatment plan.

5. What happens if I miss a dose?

Contact your healthcare provider for advice. Do not take a double dose to make up for a missed dose unless specifically instructed.

6. What are the common side effects of temozolomide?

Common side effects include nausea, vomiting, fatigue, headache, constipation, and decreased appetite. Your healthcare provider will monitor for more serious effects such as low blood cell counts.

7. Does temozolomide affect blood counts?

Yes. Temozolomide can lower white blood cells, red blood cells, and platelets. Regular blood tests are usually required during treatment.

8. Can pregnant women take temozolomide?

No. Temozolomide may harm an unborn baby. Pregnancy should be discussed with your healthcare provider before treatment begins.

9. Is a prescription required to buy temozolomide?

Yes. Temozolomide is available only on a valid prescription from a registered medical practitioner.

10. How should Temozolomide capsules be stored?

Store the capsules at room temperature in their original packaging, protected from moisture and excessive heat, and keep them out of the reach of children.

Manufacturer Information

Brand: TMOZOLMIDE 100

Generic Name: Temozolomide 100 mg

Dosage Form: Capsules

Pack Size: 5 Capsules

Manufactured/Marketed By: Steris Healthcare Pvt. Ltd.

Quality Standard: WHO-GMP Certified