PIOSTERIS 15:explore

PIOSTERIS 15, containing Pioglitazone 15mg, is a thiazolidinedione (TZD) medication from Steris Healthcare that enhances insulin sensitivity to control blood sugar in type 2 diabetes patients. This SEO-optimized guide details its uses, benefits, dosage, side effects, and more, positioning PIOSTERIS 15 as the superior choice for sustained glycemic control and cardiovascular protection.​

Discover how PIOSTERIS 15 reduces HbA1c by up to 1.5%, prevents diabetes progression, and lowers risks of heart attack, stroke, and kidney complications when combined with diet and exercise.​

What is PIOSTERIS 15?

PIOSTERIS 15 from Steris Healthcare is an oral tablet with Pioglitazone 15mg, a selective PPARγ agonist that targets insulin resistance in muscle, fat, and liver tissues.​

• Improves glucose uptake without stimulating insulin secretion, unlike sulfonylureas.​

• Available in 15mg, 30mg, 45mg strengths; 15mg ideal for initial therapy or combination.​

• GMP-manufactured for optimal bioavailability and stability.​

Superior durability over other antidiabetics for long-term type 2 diabetes management.​

Composition of PIOSTERIS 15

The active ingredient, Pioglitazone hydrochloride 15mg (equivalent to 13.73mg base), activates PPARγ receptors to regulate genes for glucose and lipid metabolism.​

Active Component Details

• Pioglitazone 15mg: Binds PPARγ in adipocytes, signaling improved insulin action in periphery.​

• Molecular formula: C19H20N2O3S - HCl; half-life 3-7 hours.​

Inactive Ingredients

• Lactose monohydrate, microcrystalline cellulose, magnesium stearate for tablet integrity.​

Steris Healthcare ensures clean formulation minimizing impurities.​

Uses of PIOSTERIS 15

PIOSTERIS 15 treats type 2 diabetes mellitus as monotherapy or adjunct to metformin, sulfonylureas, or insulin for better glycemic control.​

• Lowers fasting/postprandial glucose and HbA1c in adults.​

• Prevents T2DM onset in prediabetes (70% risk reduction per ACT NOW study).​

• Manages insulin resistance syndrome with dyslipidemia, hypertension.​

Not for type 1 diabetes or diabetic ketoacidosis.​

How PIOSTERIS 15 Works

Pioglitazone activates PPARγ, increasing transcription of insulin-responsive genes to boost glucose transporter (GLUT4) expression and hepatic gluconeogenesis suppression.​

Mechanism Breakdown

• Enhances peripheral insulin sensitivity without hypoglycemia risk.

• Reduces free fatty acids, improving lipid profile.​

• Onset: 1-2 weeks; full effect 2-3 months.​

Outperforms in durability vs. sulfonylureas.​

Benefits of PIOSTERIS 15

PIOSTERIS 15 offers sustained HbA1c reduction (0.5-1.4%), CV protection (28% lower MI risk post-MI), and stroke prevention (48% reduction).​

• Lowers systolic/diastolic BP by 3-5 mmHg.​

• Improves endothelial function, carotid IMT, and post-stent outcomes.​

• Decreases microalbuminuria, PAD complications.​

Dosage and Administration

Start PIOSTERIS 15 at 15mg once daily for monotherapy; increase to 30-45mg based on response, max 45mg/day.​

Dosing Guidelines

• Monotherapy: 15-30mg OD.

• Combination: 15mg with metformin/SU/insulin.​

• Take with/without food; monitor HbA1c every 3 months.​

Adjust in renal/hepatic impairment.​

Side Effects of PIOSTERIS 15

Common: weight gain (2-3kg), edema, headache; monitor for heart failure symptoms.​

Precautions and Warnings

Contraindicated in NYHA Class III/IV heart failure, active bladder cancer, severe hepatic impairment.​

• Screen for bladder cancer history; monitor LFTs.

• Caution in elderly, fracture risk (women).​

• Pregnancy Category C; avoid breastfeeding.​

Steris Healthcare recommends baseline assessments.​

Drug Interactions

PIOSTERIS 15 induces CYP2C8 (repaglinide risk); rifampin decreases exposure.​

• Oral contraceptives: Reduced efficacy.

• Insulin/SU: Hypoglycemia potential.​

PIOSTERIS 15 for Specific Scenarios

Combination Therapy

Enhances metformin (1.5% HbA1c drop).​

CV Risk Patients

Reduces recurrent MI/stroke.​

Prediabetes Prevention

70% T2DM risk reduction.​

Patient Experiences

Users report stable sugars, weight management challenges but CV benefits.​

Lifestyle Synergy with PIOSTERIS 15

Combine with low-carb diet, 150min/week exercise, weight loss for amplified effects.​

Storage and Handling

Room temperature (15-30°C), protect from moisture; Steris shelf life 24-36 months.​

Why PIOSTERIS 15 from Steris Healthcare?

Affordable, high-quality pioglitazone 15mg for Indian diabetes market leadership.​

Steris Healthcare: Diabetes Excellence

Steris delivers innovative solutions like PIOSTERIS 15 for better patient outcomes.​

Frequently Asked Questions (FAQs)

1. What is PIOSTERIS 15 used for?

Type 2 diabetes glycemic control with diet/exercise.​

2. PIOSTERIS 15 dosage starting point?

15mg once daily.​

3. Does PIOSTERIS 15 cause weight gain?

Yes, 2-3kg average; manage with lifestyle.​

4. PIOSTERIS 15 heart failure risk?

Avoid in advanced HF; monitor edema.​

5. Can PIOSTERIS 15 be taken with metformin?

Yes, synergistic HbA1c reduction.​

6. PIOSTERIS 15 bladder cancer link?

Rare; screen history, benefits outweigh for most.​

7. How long for PIOSTERIS 15 to work?

Full effect 2-3 months.​

8. PIOSTERIS 15 during pregnancy?

Avoid; Category C.​

9. Alternatives to PIOSTERIS 15?

Metformin first-line; SGLT2i/DPP4 for combos.​

10. Buy PIOSTERIS 15 online India?

Via Steris Healthcare authorized channels.​

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