Nintedanib 150 mg Uses, Mechanism, Side Effects & Dosage

Chronic lung conditions such as idiopathic pulmonary fibrosis (IPF) and progressive interstitial lung diseases (ILDs) can significantly affect the quality of life. These drug conditions cause scarring of lung tissue, which reduces lung capacity and makes breathing difficult. Without effective management, patients are at risk of severe respiratory complications.

NINTEDONE 150, containing Nintedanib 150 mg, is a cutting-edge therapeutic option for patients suffering from IPF and other fibrotic lung disorders. Manufactured by Steris Healthcare Pvt. Ltd., this medicine helps slow disease progression, preserve lung function, and enhance daily living for patients with chronic lung fibrosis.

NINTEDONE 150 is recognized for its targeted mechanism, clinical efficacy, and tolerable safety profile, making it a trusted choice among pulmonologists and patients alike.

What is Nintedanib 150 mg?

Nintedanib is a tyrosine kinase inhibitor that blocks multiple pathways responsible for abnormal fibrotic tissue formation in the lungs. By inhibiting receptors such as VEGF, FGF, and PDGF, NINTEDONE 150 slows the progression of lung fibrosis and maintains lung function.

Key Benefits of Nintedanib:

• Reduces lung tissue scarring

• Slows decline in forced vital capacity (FVC)

• Improves exercise tolerance

• Supports overall respiratory health

NINTEDONE 150 is intended for adult patients diagnosed with IPF or progressive fibrosing ILDs, offering a reliable option for long-term management.

Composition of NINTEDONE 150

Each capsule contains:

• Nintedanib 150 mg

This dosage is formulated for maximum therapeutic effect while maintaining a safe and tolerable side effect profile.

Mechanism of Action

NINTEDONE 150 works by:

1. Inhibiting Tyrosine Kinase Receptors

   • Targets VEGF, FGF, and PDGF receptors, which are crucial in fibrotic processes.

2. Reducing Fibrosis Progression

   • Slows abnormal tissue remodeling and lung scarring.

3. Preserving Lung Function

   • Helps maintain FVC and other key lung function measures.

4. Enhancing Quality of Life

   • Reduces symptoms like breathlessness, fatigue, and chronic cough.

Uses of NINTEDONE 150

1. Idiopathic Pulmonary Fibrosis (IPF)

NINTEDONE 150 is primarily prescribed to slow disease progression in IPF patients, helping them maintain lung capacity and reduce the risk of respiratory complications.

2. Progressive Fibrosing Interstitial Lung Diseases (ILDs)

For patients with fibrosing ILDs showing disease progression, NINTEDONE 150 can:

• Reduce lung scarring

• Preserve lung function

• Improve exercise tolerance and daily activity levels

3. Supportive Lung Care

• Alleviates breathlessness and chronic fatigue

• Enhances oxygen utilization

• Supports long-term respiratory health

Benefits of NINTEDONE 150

• Slows Disease Progression: Limits fibrosis development in the lungs.

• Preserves Lung Function: Maintains FVC and overall respiratory capacity.

• Improves Quality of Life: Reduces breathing difficulties and fatigue.

• Targeted Mechanism: Acts on multiple fibrotic pathways for effective management.

• Long-Term Therapy: Safe for prolonged use under medical supervision.

Dosage and Administration

Recommended Adult Dosage

• Standard Dose: 150 mg capsules, taken twice daily (morning and evening)

• Administration: Swallow capsules whole with water, with or without food

• Consistency: Take at the same time daily to maintain steady drug levels

Dose Adjustments

• Dose modifications may be required for patients with liver impairment or severe side effects.

• Always follow the guidance of your pulmonologist or healthcare provider.

Side Effects of NINTEDONE 150

Common side effects include:

• Diarrhea

• Nausea or vomiting

• Abdominal pain

• Fatigue

• Liver enzyme elevation (rare)

Important: Contact your doctor if you experience severe diarrhea, jaundice, unexplained bruising, or persistent nausea. Regular liver function monitoring is advised.

Precautions and Warnings

• Pregnancy & Breastfeeding: Not recommended; consult a physician if necessary.

• Liver Impairment: Dose adjustments may be required; liver function tests should be monitored.

• Gastrointestinal Concerns: Maintain hydration and report persistent diarrhea.

• Medication Interactions: Inform your doctor about all other medications, including anticoagulants and enzyme inhibitors.

• Regular Monitoring: Pulmonary function and liver tests are advised during treatment.

Lifestyle Tips to Complement NINTEDONE 150 Therapy

• Balanced Diet: Eat nutrient-rich foods to support lung and immune health.

• Stay Hydrated: Helps manage gastrointestinal side effects.

• Exercise as Tolerated: Light activities support lung function and stamina.

• Avoid Smoking and Pollutants: Protect lungs from further damage.

• Routine Checkups: Follow-up appointments with a pulmonologist are essential.

Who Should Use NINTEDONE 150?

• Adults with idiopathic pulmonary fibrosis

• Patients with progressive fibrosing ILDs

• Individuals aiming to slow lung fibrosis and preserve respiratory function

• Patients under regular medical supervision for chronic lung conditions

Who Should Avoid NINTEDONE 150?

• Pregnant or breastfeeding women

• Patients with severe liver disease

• Individuals allergic to nintedanib or capsule excipients

• Patients not under regular healthcare monitoring

Drug Interactions

Inform your doctor if taking:

• Anticoagulants (e.g., warfarin)

• Antifungal agents

• Enzyme inhibitors or inducers

• Other medications affecting liver metabolism

Drug interactions can alter drug levels and increase side effect risks.

Storage Instructions

• Store below 30°C in a dry, cool place

• Protect from moisture and sunlight

• Keep out of reach of children

• Do not use after expiry date

Conclusion

NINTEDONE 150 (Nintedanib 150 mg) is a highly effective, targeted therapy for managing idiopathic pulmonary fibrosis and progressive fibrosing interstitial lung diseases. Its multi-pathway tyrosine kinase inhibition slows lung scarring, preserves lung function, and enhances quality of life for patients.

Frequently Asked Questions 

1. How long before NINTEDONE 150 shows benefits?

• Nintedanib slows disease progression over several months; consistent use is essential.

2. Can I take it with food?

• Yes, capsules can be taken with or without meals.

3. What if I miss a dose?

• Take it as soon as possible unless it is near the next scheduled dose.

4. Is long-term use safe?

• Yes, under regular monitoring of liver function and lung health.

5. Can NINTEDONE 150 be combined with other medications?

• Only under medical supervision can interactions occur with anticoagulants and liver enzyme modulators.