Metformin SR (500mg), Teneligliptin (20mg) ... . . . . . . .

Type 2 diabetes mellitus (T2DM) is one of the most common lifestyle-related metabolic disorders in India, affecting millions of adults across urban and rural populations. Managing blood glucose levels effectively is crucial to prevent long-term complications such as heart disease, kidney damage, neuropathy, and vision problems. Combination therapies have become the cornerstone of modern diabetes care, especially when single-drug treatment fails to maintain optimal glycaemic control.

TENELIGOLD M 500 is a scientifically formulated oral antidiabetic medication containing Metformin SR (500 mg) and Teneligliptin (20 mg). This dual-drug combination targets multiple pathophysiological mechanisms of type 2 diabetes, offering better and sustained blood sugar control with improved patient compliance. Designed for once-daily use, TENELIGOLD M 500 is widely prescribed by physicians for patients who require effective glucose regulation with a lower risk of hypoglycaemia.

Composition Overview

• Metformin Sustained Release 500 mg

• Teneligliptin 20 mg

This combination works synergistically to reduce blood glucose levels, improve insulin sensitivity, and regulate postprandial sugar spikes.

Uses of TENELIGOLD M 500

Metformin SR (500mg), Teneligliptin (20mg) is primarily used for the management of Type 2 Diabetes Mellitus in adults. It is prescribed when diet, exercise, and monotherapy with metformin or other oral antidiabetic agents are insufficient to control blood sugar levels.

Key therapeutic uses include:

• Control of fasting and postprandial blood glucose levels

• Improvement of glycaemic control in patients with insulin resistance

• Prevention of diabetes-related microvascular and macrovascular complications

• Long-term diabetes management in overweight or obese patients

• As an add-on therapy when single-drug treatment is inadequate

This medicine is not indicated for Type 1 diabetes or diabetic ketoacidosis.

How TENELIGOLD M 500 Works

Metformin SR
Metformin is the first-line therapy for type 2 diabetes. In its sustained-release form, it provides prolonged action with better gastrointestinal tolerance. It works by:

• Reducing glucose production in the liver

• Improving insulin sensitivity in peripheral tissues

• Decreasing intestinal absorption of glucose

Teneligliptin
Teneligliptin belongs to the DPP-4 inhibitor class. It enhances the action of incretin hormones, which:

• Increase insulin secretion in a glucose-dependent manner

• Reduce glucagon release

• Control post-meal blood sugar spikes

Together, these two agents offer balanced and consistent glycaemic control throughout the day.

Benefits of TENELIGOLD M 500

1. Dual Mechanism for Better Control
   Addresses both insulin resistance and impaired insulin secretion.

2. Sustained Blood Sugar Regulation
   Metformin SR ensures steady glucose control with fewer fluctuations.

3. Low Risk of Hypoglycaemia
   Teneligliptin acts in a glucose-dependent manner, minimizing sudden sugar drops.

4. Weight Neutral or Weight Friendly
   Unlike some antidiabetic drugs, this combination does not promote weight gain.

5. Improved Patient Compliance
   Once-daily dosing simplifies treatment routines.

6. Cardio-Metabolic Support
   Helps reduce long-term cardiovascular risks associated with uncontrolled diabetes.

7. Suitable for Indian Patients
   Teneligliptin is known for its effectiveness and safety profile in Indian populations.

Dosage and Administration

• Recommended Dose: One tablet of TENELIGOLD M 500 once daily

• Best Time to Take: With or after meals, preferably at the same time each day

• Route: Oral

The dosage should be strictly followed as prescribed by a healthcare professional. Dose adjustments may be required based on blood glucose levels, renal function, and individual patient response.

Do not crush or chew the tablet, as it is a sustained-release formulation.

Side Effects

Like all medicines, TENELIGOLD M 500 may cause some side effects, though not everyone experiences them.

Common side effects:

• Nausea

• Diarrhoea

• Abdominal discomfort

• Flatulence

• Headache

Less common but important side effects:

• Dizziness

• Loss of appetite

• Mild skin reactions

Rare but serious side effects:

• Lactic acidosis (very rare, associated with metformin)

• Severe allergic reactions

If any unusual or persistent symptoms occur, medical attention should be sought immediately.

Warnings

• Not recommended for patients with severe kidney impairment

• Use with caution in elderly patients

• Temporary discontinuation may be required before major surgery or radiological procedures involving contrast agents

• Avoid excessive alcohol consumption, as it increases the risk of lactic acidosis

• Not indicated during episodes of dehydration or severe infection

Precautions

Before starting TENELIGOLD M 500, inform your doctor if you have:

• Kidney or liver disease

• Heart failure

• History of pancreatitis

• Alcohol dependency

Special precautions:

• Regular monitoring of blood glucose and HbA1c levels is advised

• Periodic kidney function tests are recommended

• Maintain a healthy diet and exercise routine alongside medication

• Pregnant or breastfeeding women should use this medicine only if clearly advised by a doctor

This medicine should always be taken under medical supervision for optimal safety and effectiveness.

Conclusion

TENELIGOLD M 500 is a reliable and effective combination therapy for patients with Type 2 diabetes who require better glycaemic control than monotherapy can provide. With the proven benefits of Metformin SR 500 mg and Teneligliptin 20 mg, this formulation offers comprehensive glucose regulation, improved insulin response, and enhanced patient compliance.

When combined with a healthy lifestyle, regular monitoring, and medical guidance, TENELIGOLD M 500 plays a vital role in long-term diabetes management and helps patients lead healthier, more active lives. Always consult a healthcare professional before starting or adjusting this medication to ensure safe and effective treatment.

Frequently Asked Questions (FAQs)

Q1. What is TENELIGOLD M 500 used for?
It is used to manage Type 2 diabetes mellitus by controlling blood sugar levels effectively.

Q2. Can TENELIGOLD M 500 cause hypoglycaemia?
The risk is low when taken alone, but it may increase if combined with insulin or sulfonylureas.

Q3. Is TENELIGOLD M 500 safe for long-term use?
Yes, when taken as prescribed and with regular medical monitoring, it is safe for long-term diabetes management.

Q4. Can this medicine be taken by elderly patients?
Yes, but with careful dose adjustment and regular kidney function monitoring.

Q5. What should I do if I miss a dose?
Take it as soon as you remember. If it is close to the next dose, skip the missed one. Do not double the dose.