Mesalamine DR (500mg) & MESALMILE 500 PR : Tablet View Uses, Side Effects, Dosage, Mechanism of action...

Mesalamine DR (500mg) & MESALMILE 500 PR 

Mesalamine DR (500mg), marketed under the brand name MESALMILE 500 PR, is a delayed-release formulation of mesalamine, also known as 5-aminosalicylic acid (5-ASA). This medication is primarily used in the management and treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. Mesalamine works by reducing inflammation directly in the colon, providing relief from symptoms and promoting mucosal healing. This article delves into the uses, benefits, side effects, and important considerations regarding MESALMILE 500 PR.

Understanding Mesalamine DR (500mg)

What is Mesalamine DR?

Mesalamine DR (delayed-release) is a form of mesalamine that is specially coated to release the active drug slowly and directly into the intestines. This delayed-release mechanism ensures that the medication bypasses the stomach, reducing potential gastric irritation and delivering the therapeutic effect precisely where it is needed.

How Does Mesalamine Work?

Mesalamine is an anti-inflammatory agent that works by inhibiting the production of pro-inflammatory chemicals in the colon. It achieves this by blocking the activity of cyclooxygenase and lipoxygenase enzymes, which are involved in the synthesis of prostaglandins and leukotrienes, respectively. These substances contribute to inflammation, swelling, and pain in the intestinal lining.

Uses of MESALMILE 500 PR

Ulcerative Colitis

MESALMILE 500 PR is widely prescribed for the treatment of mild to moderate ulcerative colitis. It helps reduce symptoms such as abdominal pain, diarrhea, and rectal bleeding by targeting inflammation in the colon. Regular use of mesalamine can also help maintain remission and prevent flare-ups.

Crohn's Disease

While mesalamine is less commonly used for Crohn's disease compared to ulcerative colitis, it can still be beneficial for managing inflammation in specific parts of the gastrointestinal tract. MESALMILE 500 PR may be prescribed as part of a broader treatment plan for patients with Crohn's disease affecting the colon.

Benefits of MESALMILE 500 PR

Targeted Delivery

The delayed-release formulation of MESALMILE 500 PR ensures that mesalamine is delivered directly to the colon, maximizing its therapeutic effect and minimizing systemic absorption. This targeted approach helps achieve better control of inflammation with fewer side effects.

Reduced Gastrointestinal Side Effects

By bypassing the stomach and releasing the drug in the intestines, MESALMILE 500 PR minimizes the risk of gastric irritation and other gastrointestinal side effects that can be associated with conventional mesalamine tablets.

Maintenance of Remission

For patients with ulcerative colitis, long-term use of MESALMILE 500 PR can help maintain remission and prevent recurrent flare-ups. Consistent use as prescribed by a healthcare provider is crucial for the ongoing management of the disease.

Dosage and Administration

Recommended Dosage

The typical dosage of MESALMILE 500 PR for adults is 500mg taken orally, usually two to four times daily, depending on the severity of the condition and the patient's response to treatment. It is essential to follow the dosing instructions provided by your healthcare provider.

Administration Tips

• Take with Water: Swallow MESALMILE 500 PR tablets whole with a full glass of water. Do not crush, chew, or break the tablets, as this can interfere with the delayed-release mechanism.
• Consistent Timing: Take your doses at the same times each day to maintain consistent drug levels in your system.
• With or Without Food: MESALMILE 500 PR can be taken with or without food, but taking it with food may help reduce any potential stomach discomfort.

Potential Side Effects

Common Side Effects

While MESALMILE 500 PR is generally well-tolerated, some patients may experience side effects, including:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Flatulence

Serious Side Effects

Serious side effects are rare but can occur. 

• Severe abdominal pain or cramping
• Bloody diarrhea
• Unexplained fever
• Chest pain
• Shortness of breath
• Severe skin rash or itching

Precautions and Considerations

Before Taking MESALMILE 500 PR

• Medical History: Inform your healthcare provider about your medical history, especially if you have kidney disease, liver disease, or a history of heart conditions.
• Allergies: Notify your doctor if you have any known allergies to mesalamine or other salicylates.
• The safety of mesalamine during pregnancy and breastfeeding should be discussed with your doctor.

Drug Interactions

Mesalamine may interact with other medications, potentially altering their effects. Inform your healthcare provider about all prescription and over-the-counter medications, supplements, and herbal products you are taking to avoid potential interactions.

Conclusion

MESALMILE 500 PR (Mesalamine DR 500mg) is a valuable medication for managing inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. Its targeted delivery system ensures maximum therapeutic effect in the colon with minimal systemic absorption, making it an effective and well-tolerated option for long-term use. By adhering to the prescribed treatment plan, patients can achieve better control of their symptoms, maintain remission, and improve their overall quality of life. Steris Healthcare Pvt Ltd, established in February 2018 by seasoned professionals in the pharmaceutical sector, operates under the name Sterispharma. Headquartered in Navi Mumbai, the company is certified by WHO, GMP, and ISO. Sterispharma is dedicated to providing high-quality medications at affordable prices across India, adhering to stringent WHO guidelines. They offer an online pharmacy platform for easy medicine purchases and home delivery. The company's mission is to deliver a diverse range of healthcare products catering to the varied needs of the medical community. From advanced treatments and rare condition medications to essential health supplies, Sterispharma aims to meet the extensive demands of the healthcare industry. Their product range covers numerous health fields, including Cardiology, Asthma, Respiratory issues, Nasal conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental care, and Dermatology.

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