Irbesartan HCI(150mg) & IRBISTRUM 150 Mg : View Uses, Dosage, Side Effects

IRBISTRUM 150 is a clinically proven antihypertensive medicine containing Irbesartan Hydrochloride (150 mg), a widely trusted angiotensin II receptor blocker (ARB). It is prescribed for adults dealing with high blood pressure (hypertension) and is also beneficial in protecting the kidneys in patients with type 2 diabetes and hypertension. As cardiovascular conditions rise across India, safe and effective medicines like IRBISTRUM 150 play a crucial role in helping patients maintain long-term heart and kidney health.

Irbesartan works by blocking the action of angiotensin II, a natural chemical that tightens blood vessels. When this chemical is blocked, blood vessels relax and widen, helping reduce pressure on the arteries. This relaxation leads to smoother blood flow, healthier cardiac functioning, and reduced complications associated with chronic hypertension.

Whether prescribed alone or in combination with other antihypertensive medications, IRBISTRUM 150 supports day-to-day blood pressure control, ensuring patients feel more confident in managing their condition. The formulation is designed to offer consistent absorption and long-lasting benefits, making it suitable for once-daily therapy.

2. Medicine Description

IRBISTRUM 150 contains Irbesartan Hydrochloride 150 mg, which belongs to the ARB class of antihypertensive drugs. ARBs are known for their excellent tolerance profile, especially for patients who cannot use ACE inhibitors due to persistent cough.

Key Characteristics of IRBISTRUM 150:

• Class: Angiotensin II Receptor Blocker (ARB)

• Strength: 150 mg

• Type: Oral tablet

• Primary Use: High blood pressure management

• Secondary Use: Kidney protection in diabetic patients

• Frequency: Typically once a day

• Tolerance: Well-tolerated with minimal side effects

The tablet is formulated to ensure steady release, consistent plasma levels, and reliable daily control of hypertension.

3. How IRBISTRUM 150 Works

Irbesartan, the active ingredient, selectively blocks the angiotensin II type 1 (AT1) receptor. This prevents angiotensin II from binding and triggering:

• Vasoconstriction (narrowing of blood vessels)

• Aldosterone release (leading to fluid retention)

• Increased blood pressure

By interrupting this mechanism, IRBISTRUM 150:

• Lowers systemic blood pressure

• Reduces workload on the heart

• Improves blood vessel function

• Prevents long-term organ damage

For diabetic patients, Irbesartan also helps reduce the progression of kidney disease by decreasing microalbuminuria.

4. Before Using IRBISTRUM 150

Before starting this medicine, patients should discuss their medical history, ongoing drugs, and lifestyle habits with their healthcare provider.

Inform Your Doctor If You Have:

• Severe kidney disorder

• Liver disease

• Heart failure

• Dehydration

• History of angioedema

• Severe electrolyte imbalance

• Narrowed arteries supplying kidneys

Pregnant women should not take Irbesartan due to the risk of fetal harm. Similarly, those planning pregnancy must consult their doctor.

5. Allergies

Patients allergic to Irbesartan or any excipient in the tablet should avoid IRBISTRUM 150. Signs of an allergic reaction include:

• Swelling of lips, face, throat

• Difficulty breathing

• Severe rash

• Intense itching

Discontinue use and seek emergency medical help if these occur.

6. Pediatric Use

IRBISTRUM 150 is not recommended for children below 18 years, as safety and efficacy data for this age group are not well established.

7. Geriatric Use

Older adults generally tolerate Irbesartan well. However:

• Kidney function

• Electrolytes (especially potassium)

• Blood pressure

should be monitored regularly. Dose adjustment may be required based on individual response.

8. Breastfeeding

It is unknown whether Irbesartan passes into breast milk, but ARBs are generally avoided during breastfeeding. Healthcare professionals may prescribe alternative therapy depending on maternal needs.

9. Drug Interactions

IRBISTRUM 150 can interact with several medications, potentially altering its effectiveness or increasing risks.

Major Interactions Include:

1. Potassium-sparing diuretics

• Spironolactone

• Eplerenone

• Amiloride

These may increase potassium levels.

2. NSAIDs

• Ibuprofen

• Diclofenac

• Naproxen

Long-term use may reduce the antihypertensive effect.

3. Other antihypertensive agents

• Beta-blockers

• Calcium channel blockers

• Diuretics

Combination may cause excessive blood pressure lowering.

4. Lithium

Irbesartan can increase lithium levels and toxicity risk.

10. Other Interactions

• High-potassium foods or supplements may lead to hyperkalemia.

• Alcohol may increase dizziness and blood pressure reduction.

• Dehydration due to vomiting or diarrhea may worsen kidney function while on Irbesartan.

11. Other Medical Problems

IRBISTRUM 150 should be used cautiously in people with:

• Renal artery stenosis

• Severe heart failure

• Liver impairment

• Electrolyte imbalance

• Dehydration

Physician evaluation is essential before therapy initiation.

12. Proper Use of IRBISTRUM 150

How to Take:

• Take one tablet daily, with or without food.

• Try to take it at the same time every day for consistent control.

• Swallow the tablet whole with water.

Do Not:

• Crush or chew the tablet

• Take double doses

• Stop medication abruptly

Blood pressure medicines must be taken regularly, even if you feel well.

13. Dosing

The dosage is determined by the prescribing doctor based on the patient’s condition and treatment goals.

Typical Adult Dose:

• 150 mg once daily
  This dose effectively controls mild to moderate hypertension.

In Diabetic Nephropathy:

• 300 mg per day may be prescribed based on patient tolerance and kidney function.

Dose Adjustments:

Required in:

• Elderly patients

• Those with kidney disease

• Those on multiple antihypertensives

14. Missed Dose

If you miss a dose:

• Take it as soon as you remember

• If it's almost time for the next dose, skip the missed one

• Do not double the dose

Consistency is vital to controlling blood pressure.

15. Storage

• Store in a cool, dry place below 25°C

• Protect from moisture and sunlight

• Keep out of reach of children

• Do not use expired tablets

16. Precautions

• Avoid alcohol to prevent excessive blood pressure reduction

• Monitor potassium levels regularly

• Monitor kidney function periodically

• Stay hydrated during treatment

• Inform doctors before surgery or dental procedures

• Pregnant women must strictly avoid Irbesartan

17. Side Effects

Although well-tolerated, some patients may experience mild to moderate side effects:

Common Side Effects:

• Dizziness

• Fatigue

• Headache

• Nausea

• Muscle pain

• Low blood pressure

Less Common:

• Increased potassium levels

• Kidney function changes

• Heart palpitations

• Abdominal discomfort

Rare but Serious:

• Allergic reactions

• Severe drop in blood pressure

• Worsening kidney condition

If severe side effects occur, consult a doctor immediately.

18. Benefits of IRBISTRUM 150

• Provides reliable 24-hour blood pressure control

• Protects kidneys in diabetic patients

• Reduces the risk of stroke and heart attack

• Well-tolerated alternative for ACE inhibitor–induced cough

• Once-daily dose improves adherence

• Helps maintain long-term cardiovascular health

19. Why Doctors Prescribe IRBISTRUM 150

• Effective for long-term hypertension control

• Suitable for patients intolerant to ACE inhibitors

• Offers renal protective benefits

• Minimal drug-related cough

• Better tolerance in Indian patients

20. Conclusion

IRBISTRUM 150, powered by Irbesartan HCl 150 mg, stands as a dependable and effective antihypertensive therapy for managing high blood pressure and protecting kidney function in diabetic patients. Its action as an angiotensin II receptor blocker allows for smoother blood flow, reduced cardiac strain, and improved long-term cardiovascular health.