Eplerestat SR 150mg

Introduction

EPSTATE SR 150 contains Epalrestat (150mg), an aldose reductase inhibitor primarily used for managing diabetic neuropathy. Diabetic neuropathy is a common complication of diabetes, causing nerve damage, pain, numbness, and weakness, particularly in the limbs. EPSTATE SR 150 helps slow down the progression of nerve damage by reducing the accumulation of sorbitol, a harmful sugar alcohol, in nerve cells.

This medication is commonly prescribed for individuals suffering from peripheral diabetic neuropathy, offering relief from symptoms like tingling sensations, burning pain, and loss of sensation in the extremities. As an extended-release formulation, EPSTATE SR 150 provides prolonged therapeutic effects, reducing the frequency of dosing while maintaining effective symptom management.

Key Ingredients

• Epalrestat (150mg) – An aldose reductase inhibitor that helps reduce nerve damage caused by high blood sugar levels.

• Excipients – Various inactive ingredients that help in the formulation of the tablet for extended release and better absorption.

How EPSTATE SR 150 Works

Epalrestat works by inhibiting aldose reductase, an enzyme that converts glucose into sorbitol. In diabetic patients, excessive sorbitol accumulation in nerve cells leads to oxidative stress and nerve damage. By blocking this enzyme, EPSTATE SR 150 reduces the accumulation of sorbitol, thereby preventing further nerve damage and improving nerve function.

Mechanism of Action

1. Aldose Reductase Inhibition – Prevents excessive sorbitol formation in nerve cells.

2. Reduces Oxidative Stress – Helps in reducing free radical damage in nerves.

3. Improves Nerve Conduction – Enhances nerve function and reduces symptoms of diabetic neuropathy.

4. Relieves Pain and Numbness – Provides symptomatic relief in diabetic neuropathy.

Uses of EPSTATE SR 150

• Treatment of diabetic peripheral neuropathy

• Prevention of further nerve damage in diabetic patients

• Alleviation of neuropathic pain, numbness, and tingling sensations

• Improvement of nerve function in chronic diabetic conditions

Dosage and Administration

Recommended Dosage

• The usual dose of EPSTATE SR 150 is one tablet once daily, preferably with food.

• The dosage may be adjusted based on the severity of neuropathy and medical advice.

• Do not exceed the prescribed dose without consulting a healthcare professional.

How to Take EPSTATE SR 150?

• Swallow the tablet whole with water.

• Take it at the same time each day for better results.

• Do not crush, chew, or break the tablet.

Benefits of EPSTATE SR 150

1. Prevents Nerve Damage

By inhibiting aldose reductase, EPSTATE SR 150 prevents excessive accumulation of sorbitol, which otherwise contributes to nerve damage.

2. Reduces Neuropathic Pain

This medication helps alleviate burning sensations, tingling, and numbness commonly experienced in diabetic neuropathy.

3. Improves Nerve Function

Regular use of EPSTATE SR 150 enhances nerve conduction and response, improving overall quality of life.

4. Supports Long-Term Diabetes Management

By addressing diabetic neuropathy, EPSTATE SR 150 aids in better diabetes control and prevents further complications.

Side Effects of EPSTATE SR 150

Although generally well-tolerated, EPSTATE SR 150 may cause some side effects in certain individuals. Common side effects include:

Mild Side Effects:

• Nausea

• Vomiting

• Stomach discomfort

• Dizziness

• Skin rash

• Fatigue

Serious Side Effects (Rare):

• Severe allergic reactions (swelling, difficulty breathing)

• Liver dysfunction (yellowing of skin, dark urine)

• Severe gastrointestinal disturbances

If you experience any serious side effects, consult your doctor immediately.

Precautions and Warnings

Who Should Avoid EPSTATE SR 150?

• Individuals allergic to Epalrestat or any excipient in the formulation.

• Patients with severe liver or kidney disease.

• Pregnant or breastfeeding women (only to be used if prescribed by a doctor).

Important Precautions

• Monitor Blood Sugar Levels – Regularly check blood sugar levels while using EPSTATE SR 150 to ensure effective diabetes management.

• Avoid Alcohol Consumption – Alcohol may worsen side effects and reduce the medication’s effectiveness.

• Liver Function Monitoring – Patients with pre-existing liver conditions should undergo periodic liver function tests.

Drug Interactions

Before starting EPSTATE SR 150, inform your doctor about any medications you are taking, as certain drugs may interact with Epalrestat:

• Antidiabetic medications (Metformin, Insulin, Glimepiride) – No significant interactions but should be monitored.

• NSAIDs (Ibuprofen, Aspirin) – May increase the risk of gastrointestinal irritation.

• Certain Antibiotics (Rifampicin, Erythromycin) – Can affect the metabolism of Epalrestat.

• Liver Enzyme Modifiers (Rifampin, Carbamazepine) – May alter the effectiveness of EPSTATE SR 150.

Frequently Asked Questions (FAQs)

1. How long does it take for EPSTATE SR 150 to show results?

The benefits of EPSTATE SR 150 may be noticeable within a few weeks of regular use. However, it may take several months for significant nerve function improvement.

2. Can I stop taking EPSTATE SR 150 if my symptoms improve?

No, you should continue taking the medication as prescribed by your doctor. Stopping it suddenly may lead to a recurrence of neuropathy symptoms.

3. Is EPSTATE SR 150 safe for long-term use?

Yes, EPSTATE SR 150 is generally safe for long-term use under medical supervision. Regular monitoring of liver function and blood sugar levels is advised.

4. Can I take EPSTATE SR 150 with other diabetic medications?

Yes, EPSTATE SR 150 is often prescribed along with other diabetic medications. However, always consult your doctor before combining it with other treatments.

5. Does EPSTATE SR 150 cure diabetic neuropathy?

No, EPSTATE SR 150 does not cure diabetic neuropathy but helps in managing its symptoms and preventing further nerve damage.

Price and Availability in India

The price of EPSTATE SR 150 may vary based on location and pharmacy. On average, a strip of 10 tablets costs around ₹200-₹500. It is available in most medical stores and online pharmacies.

Conclusion

EPSTATE SR 150 (Epalrestat Extended-Release 150mg) is a valuable medication for managing diabetic peripheral neuropathy. By inhibiting aldose reductase, it helps reduce nerve damage, alleviate neuropathic pain, and improve nerve function. When taken as prescribed, EPSTATE SR 150 offers a safe and effective way to manage diabetes-related nerve complications.

Always consult a doctor before starting EPSTATE SR 150 and ensure regular medical check-ups to monitor its effectiveness and safety.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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