Entecavir 1 mg Tablet for Hepatitis B Treatment: ENTACOVER 1

Introduction

ENTACOVER 1 contains entecavir 1 mg, an advanced antiviral agent used in the long-term treatment of chronic Hepatitis B virus (HBV) infection. As part of the nucleoside analog reverse transcriptase inhibitors (NRTIs) class, Entecavir is a preferred first-line antiviral recommended by major global guidelines including AASLD, EASL, and WHO.Chronic HBV infection can silently progress to liver fibrosis, cirrhosis, or hepatocellular carcinoma (HCC). Early initiation of entecavir therapy helps suppress viral replication, prevent liver damage, and reduce the risk of liver cancer.

Composition Details

Each film-coated tablet of ENTACOVER 1 contains:

• Entecavir Monohydrate Equivalent to Entecavir 1 mg

Mechanism of Action: How Entecavir Works

Entecavir is a guanosine nucleoside analog. It inhibits all three functions of the HBV DNA polymerase enzyme:

1. Priming of HBV DNA polymerase

2. Reverse transcription of negative-strand DNA

3. Synthesis of the positive strand

This leads to:

• Reduction of HBV DNA levels

• Decreased ALT (liver enzyme) levels

• Improvement in liver histology

Indications: Who Should Use Tab Entecavir 1 mg

ENTACOVER 1 is indicated in:

• Adults and children ≥2 years of age with chronic HBV infection and active liver inflammation

• Patients who are HBeAg-positive or HBeAg-negative

• Lamivudine-resistant cases (entecavir 1 mg dose is preferred)

• Compensated and decompensated liver disease

• Post-liver transplant patients with HBV reactivation

Dosage and Administration

Important:

• Administer on an empty stomach, at least 2 hours before or after food

• Do not break or chew the tablet. Swallow whole with water.

Clinical Efficacy and Studies

Numerous clinical trials have proven entecavir’s efficacy:

90% HBV DNA suppression within 48–96 weeks

• Histological improvement in liver biopsy

• Lower resistance rates than lamivudine and adefovir

• Long-term therapy (>5 years) shows sustained viral suppression with minimal toxicity

Benefits of ENTACOVER 1 (Entecavir 1 mg Tablet)

• Potent HBV DNA suppression with once-daily oral dosing

• Low resistance profile, even in long-term use

• Suitable for both treatment-naïve and lamivudine-resistant patients

• Manufactured in WHO-GMP & ISO 9001:2015 certified plants

• Affordable and accessible across India

• Trusted by hepatologists for safe, lifelong HBV management

Side Effects of Entecavir 1 mg

Common side effects:

• Headache

• Dizziness

• Nausea

• Fatigue

• Diarrhea

• Elevated liver enzymes (ALT, AST)

Serious (rare):

• Lactic acidosis

• Hepatic steatosis

• Severe hepatomegaly

Immediately report symptoms like unusual muscle pain, shortness of breath, or yellowing of the eyes/skin.

Precautions and Warnings

• Use with caution in HIV co-infected patients not on HAART – may cause HIV resistance

• Regular monitoring of HBV DNA, liver function tests, and ALT is recommended

• Not approved for Hepatitis C or Hepatitis D

• Discontinuation may lead to HBV flare-up – stop only on medical advice

• Pregnancy Category C – consult doctor before use in pregnancy or lactation

• Use with caution in renal dysfunction

Drug Interactions

• No significant interactions reported with most antivirals or antibiotics

• Use caution with nephrotoxic drugs (e.g., aminoglycosides)

• Can be safely combined with immunosuppressants post-liver transplant under supervision

Entecavir 1 mg Price and Availability

ENTACOVER 1 offers high-quality entecavir at a cost-effective price, making long-term HBV therapy affordable for Indian patients. Prices may vary by location and pack size.

To know the entecavir 1 mg price or place a bulk order, contact Steris Healthcare or your nearest authorized distributor.

Why Buy ENTACOVER 1 from Steris Healthcare Pvt Ltd?

• WHO-GMP certified & ethically manufactured

• Accurate dosing and stringent quality control

• Nationwide distribution for easy availability

• Backed by a trusted Indian pharmaceutical brand

• Doctor-endorsed and pharmacy-preferred

FAQs – Entecavir 1 mg Tablet (ENTACOVER 1)

Q1: Is entecavir 1 mg safe for long-term use?

A: Yes, it is one of the most preferred and well-tolerated antivirals for long-term HBV treatment.

Q2: Can entecavir be taken with food?

A: No. It must be taken on an empty stomach for proper absorption.

Q3: How long does it take for entecavir to show results?

A: Viral load starts dropping within weeks, but therapy is continued for months or years.

Q4: What if I miss a dose?

A: Take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose—do not double up.

Q5: Can entecavir cure hepatitis B?

A: No, it controls the virus but doesn’t eliminate it completely. It significantly reduces liver damage and viral load.

Conclusion

ENTACOVER 1 (entecavir 1 mg) from Steris Healthcare Pvt Ltd is a reliable, effective, and affordable option for the long-term management of chronic hepatitis B. With clinically proven efficacy, strong manufacturing standards, and trusted availability, it is the preferred choice of healthcare professionals across India.