Cinacalcet 30 mg Uses, Dosage, Side Effects & Structure

Cinacalcet 30 mg is an effective medication widely used to manage conditions related to excess parathyroid hormone levels. Marketed under the brand name CINASELECT 30, this tablet plays a crucial role in treating secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as certain cases of hypercalcemia. Understanding the cinacalcet 30 mg mechanism of action, dosage, and benefits can help patients use this medicine safely and effectively.

What is Cinacalcet 30 mg?

Cinacalcet 30 mg tablet is a prescription medicine known as a calcimimetic agent. It works by increasing the sensitivity of calcium-sensing receptors in the parathyroid gland. As a result, the gland reduces the production of parathyroid hormone (PTH), which helps bring down calcium and phosphorus levels in the blood.

This makes CINASELECT 30 an important option for patients with:

• Secondary hyperparathyroidism (SHPT) in chronic kidney disease patients on dialysis

• Parathyroid carcinoma (cancer of the parathyroid gland)

• Primary hyperparathyroidism when surgery is not possible

• Hypercalcemia (high calcium levels) due to parathyroid disorders

Cinacalcet Mechanism of Action

The cinacalcet mechanism of action involves modulation of the calcium-sensing receptor (CaSR) on the parathyroid gland. By binding to the receptor, cinacalcet 30 mg increases its sensitivity to circulating calcium levels. This enhanced sensitivity tricks the parathyroid gland into perceiving higher calcium concentrations than actually present, which leads to reduced secretion of parathyroid hormone (PTH).

Lowering PTH helps regulate calcium and phosphate balance in the body, reducing complications such as bone disease and vascular calcification, common in chronic kidney disease patients and certain parathyroid disorders.

Cinacalcet Structure

Cinacalcet is a small molecule characterized by its ability to interact with calcium-sensing receptors (CaSR) on parathyroid gland cells. The chemical structure includes an aromatic ring and amine groups that enable it to bind allosterically to CaSR, enhancing the receptor’s sensitivity to extracellular calcium ions. This action results in the reduction of PTH secretion.

Cinacalcet 30 mg Uses

The uses of cinacalcet 30 mg include:

• Treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis

• Management of hypercalcemia in patients with parathyroid carcinoma

• Control of primary hyperparathyroidism when surgery is not an option or has failed

• Helps reduce elevated serum calcium and PTH levels, preventing bone weakening and cardiovascular issues

Cinacalcet Dose

The dosing of cinacalcet 30 mg tablets will vary depending on the individual patient’s condition and response. Typically:

• Treatment starts with a daily dose of 30 mg taken once daily or divided into two doses.

• The dose may be adjusted every 2 to 4 weeks based on serum calcium and PTH levels to achieve optimal control.

• Maximum doses can reach up to 180 mg per day, divided as necessary.

• It is important to take cinacalcet exactly as prescribed and avoid missing doses to maintain its effectiveness.

Possible Side Effects of Cinacalcet 30 mg

While CINASELECT 30 is effective, some patients may experience side effects.

Common side effects:

• Nausea and vomiting

• Dizziness

• Weakness

• Loss of appetite

Serious side effects (seek medical help):

• Very low calcium levels (hypocalcemia) – symptoms may include muscle cramps, tingling, or seizures

• Heart rhythm changes

• Severe allergic reactions (rare)

Regular monitoring of calcium and PTH levels helps reduce the risks of side effects.

Precautions to Take

• Take cinacalcet 30 with food or shortly after a meal.

• Regular blood tests for calcium, phosphorus, and PTH levels are important.

• Inform your doctor if you have liver disease or heart conditions.

• Avoid taking this medicine without medical supervision.

Why Choose Steris Healthcare?

Steris Healthcare is a trusted name in the pharmaceutical industry, known for delivering safe, effective, and affordable medicines. With WHO-GMP certification and strict quality control, CINASELECT 30 (cinacalcet 30 mg) is manufactured with the highest standards of patient safety in mind.

By choosing Steris Healthcare, patients and healthcare providers get:

• High-quality formulations

• Affordable pricing

• Nationwide availability

• Commitment to patient care

Frequently Asked Questions

1. How long does it take for cinacalcet to work?
Most patients begin to see results within 2–4 weeks, but full effects may take a few months depending on the condition.

2. Can cinacalcet 30 mg be used in dialysis patients?
Yes, it is commonly prescribed for patients with secondary hyperparathyroidism on dialysis.

3. Does cinacalcet cure hyperparathyroidism?
It does not cure the condition but effectively controls PTH and calcium levels, reducing complications.

4. Can I stop taking cinacalcet suddenly?
No, stopping without medical advice can cause calcium and PTH levels to rise again. Always follow your doctor’s guidance.

5. Is cinacalcet safe for long-term use?
Yes, when taken under medical supervision with regular monitoring, it is considered safe for long-term treatment.

Conclusion

Cinacalcet 30 mg (CINASELECT 30) is an important medicine for patients with chronic kidney disease, parathyroid disorders, or high calcium levels. By reducing PTH and calcium levels, it protects patients from bone loss, heart problems, and other complications.

Although side effects may occur, with proper monitoring and medical supervision, cinacalcet 30 mg tablet can significantly improve patient health and quality of life.