Azilsartan Medoxomil 40 mg Tablets – Composition, Clinical Benefits, Side Effects & FAQs

Introduction

High blood pressure (hypertension) is one of the most common yet serious health concerns worldwide, often leading to cardiovascular complications if left untreated. Azilsartan Medoxomil 40 mg is an advanced antihypertensive medication used to effectively control high blood pressure and reduce associated risks such as heart attack, stroke, and kidney damage. Marketed under the brand name AZILSTRUM 40, this medicine belongs to the class of angiotensin II receptor blockers (ARBs).

Composition of AZILSTRUM 40

Each tablet of AZILSTRUM 40 contains:

• Azilsartan Medoxomil 40 mg

This active ingredient works by relaxing blood vessels, making it easier for blood to flow and thereby lowering blood pressure levels.

Pharmacology and Mechanism of Action

Azilsartan Medoxomil is a prodrug that gets converted into its active form, Azilsartan, after oral intake.

• Target: Angiotensin II Receptors (AT1 subtype)

• Action: It blocks the action of angiotensin II, a hormone responsible for narrowing blood vessels and increasing blood pressure.

• Effect: By blocking angiotensin II, the medicine relaxes blood vessels, reduces vascular resistance, and lowers blood pressure.

Additional Benefits:

• Improves arterial flexibility

• Reduces strain on the heart

• Helps prevent hypertrophy (thickening of heart muscle)

• Provides protective effects on kidneys by reducing protein loss in urine

Uses and Indications

Azilsartan Medoxomil 40 mg tablets are primarily prescribed for:

• Hypertension (High Blood Pressure): Used as monotherapy or in combination with other antihypertensive agents.

• Cardiovascular Risk Reduction: Helps lower the risk of stroke, heart attack, and heart failure.

• Kidney Protection: Particularly beneficial for patients with diabetes or chronic kidney disease where hypertension worsens kidney damage.

Clinical Evidence and Efficacy

Numerous clinical studies support the effectiveness of Azilsartan Medoxomil 40 mg:

• SUPERIOR BLOOD PRESSURE CONTROL: Research has shown that Azilsartan 40 mg lowers blood pressure more effectively than other ARBs like Valsartan, Olmesartan, and Candesartan.

• SUSTAINED ACTION: Provides long-lasting blood pressure control throughout the day and night.

• RENAL OUTCOMES: Clinical trials confirm its role in slowing the progression of diabetic nephropathy.

• CARDIOVASCULAR PROTECTION: Regular use significantly reduces the incidence of heart failure, left ventricular hypertrophy, and other cardiovascular complications.

Benefits of Azilsartan Medoxomil 40 mg

• Provides effective 24-hour blood pressure control.

• Fewer side effects compared to older antihypertensive medicines.

• Can be used alone or in combination therapy.

• Offers renal protection in hypertensive diabetic patients.

• Improves long-term cardiovascular outcomes.

Dosage and Administration

• The usual recommended dose of Azilsartan Medoxomil 40 mg is once daily.

• It can be taken with or without food.

• The dosage may be adjusted by the physician depending on the patient’s response and health condition.

• Patients are advised to take the medicine at the same time each day for best results.

Side Effects of Azilsartan Medoxomil 40 mg

While Azilsartan Medoxomil tablets 40 mg are generally safe and well-tolerated, some patients may experience:

Common Side Effects

• Dizziness or lightheadedness

• Headache

• Fatigue

• Diarrhea

• Muscle weakness or cramps

Less Common but Serious Side Effects

• Hypotension (very low blood pressure)

• Hyperkalemia (increased potassium levels)

• Impaired kidney function

• Allergic reactions (rare)

Tip: Patients should regularly monitor their blood pressure and kidney function while on this medication.

Contraindications and Precautions

Contraindications:

• Pregnancy: Can cause harm to the fetus.

• Breastfeeding: Not recommended.

• Severe kidney or liver impairment.

• Known allergy to Azilsartan or any ARBs.

Precautions:

• Patients with dehydration, heart failure, or electrolyte imbalance should use it cautiously.

• Avoid potassium supplements unless prescribed.

• Alcohol may enhance the blood pressure-lowering effect.

Drug Interactions

Azilsartan Medoxomil 40 mg may interact with other medications, including:

• Potassium-sparing diuretics (e.g., Spironolactone, Amiloride) – may increase potassium levels.

• NSAIDs (Ibuprofen, Diclofenac, etc.) – may reduce antihypertensive effect.

• Lithium – risk of lithium toxicity.

• Other antihypertensives – may increase the risk of hypotension.

Lifestyle Tips While Taking Azilsartan Medoxomil 40 mg

• Maintain a low-sodium, heart-healthy diet.

• Engage in regular physical activity such as walking, cycling, or yoga.

• Limit alcohol consumption and quit smoking.

• Monitor blood pressure regularly at home.

• Stay well hydrated but avoid excessive salt substitutes containing potassium.

Why Choose AZILSTRUM 40 from Steris Healthcare?

• Manufactured under WHO-GMP certified facilities ensuring premium quality.

• Backed by strict quality control and clinical reliability.

• Affordable pricing for wider accessibility.

• Trusted by healthcare professionals across India.

FAQs on Azilsartan Medoxomil 40 mg

Q1: What is Azilsartan Medoxomil 40 mg used for?
It is primarily used to treat high blood pressure and reduce the risk of cardiovascular diseases like stroke and heart attack.

Q2: Can I take Azilsartan Medoxomil 40 mg with other medicines?
Yes, but only under the guidance of a doctor. It is often combined with diuretics or calcium channel blockers for better results.

Q3: Is Azilsartan Medoxomil safe for long-term use?
Yes. It is considered safe for long-term use under medical supervision, provided regular health check-ups are done.

Q4: What should I avoid while taking Azilsartan Medoxomil 40 mg?
Avoid excessive alcohol, high-salt diets, and potassium-rich supplements unless prescribed by a doctor.

Conclusion

Azilsartan Medoxomil 40 mg (AZILSTRUM 40) is a reliable and effective solution for managing hypertension. With proven efficacy, kidney protection, and cardiovascular benefits, it plays a vital role in improving patients’ quality of life. When combined with lifestyle modifications such as a healthy diet, exercise, and stress management, it can significantly lower long-term health risks.