Amiodarone 100 mg

Introduction

AMIDRONE 100 is a prescription medicine that contains Amiodarone Hydrochloride IP 100 mg, a potent antiarrhythmic drug used to manage and treat life-threatening cardiac arrhythmias. It is specifically effective for ventricular arrhythmias and supraventricular tachycardias, including atrial fibrillation. Amiodarone works by prolonging the phase 3 of the cardiac action potential, effectively stabilizing the heart rhythm in patients with irregular heartbeat conditions.

Key Uses of Amiodarone 100 mg Tablets

• Ventricular Tachycardia (VT): Helps control fast and potentially fatal heart rhythms arising from the ventricles.

• Ventricular Fibrillation (VF): Used for the prevention and treatment of sudden, life-threatening fibrillation episodes.

• Atrial Fibrillation (AF): Often used when other rhythm control strategies have failed.

• Paroxysmal Supraventricular Tachycardia (PSVT)

• Maintenance of Sinus Rhythm after Cardioversion

Note: AMIDRONE 100 is generally prescribed when first-line therapies are ineffective or contraindicated.

How AMIDRONE 100 Works (Mechanism of Action)

Amiodarone belongs to Class III antiarrhythmics under the Vaughan-Williams classification. It works by:

• Blocking potassium channels (delaying repolarization)

• Inhibiting sodium and calcium channels

• Exerting non-competitive beta-blocking properties

• Increasing the refractory period of myocardial cells

This combination of actions helps normalize and stabilize cardiac rhythm, preventing abnormal electrical activity in the heart.

Dosage & Administration

Usual Adult Dosage (to be adjusted as per physician’s recommendation):

• Loading Dose: 800–1600 mg/day in divided doses for 1–3 weeks until arrhythmia is controlled.

• Maintenance Dose: Typically 100–400 mg/day.

AMIDRONE 100 is commonly used in combination to achieve the desired total daily dosage.

Route of Administration: Oral
Timing: Preferably with food to reduce gastrointestinal upset.

Caution: Dosing should always be initiated and adjusted by a qualified healthcare professional. Regular monitoring of thyroid, liver, and lung function is essential during treatment.

Side Effects of Amiodarone 100 mg Tablets

Common side effects:

• Nausea, vomiting

• Metallic taste or loss of taste

• Constipation

• Photosensitivity or skin discoloration

• Tremors or muscle weakness

• Fatigue or dizziness

Serious (but rare) side effects:

• Pulmonary toxicity (lung fibrosis)

• Thyroid dysfunction (hypo- or hyperthyroidism)

• Liver toxicity

• Corneal microdeposits (visual disturbances)

• Bradycardia and heart block

• Blue-grey skin pigmentation with prolonged use

Precautions & Warnings

• Pregnancy & Lactation: Avoid unless benefits clearly outweigh risks.

• Thyroid Disease: Monitor TSH levels regularly; amiodarone can cause both hypo- and hyperthyroidism.

• Liver & Lung Function: Regular liver enzyme and pulmonary tests are essential.

• Photosensitivity: Use sunscreen and wear protective clothing outdoors.

• Drug Accumulation: Due to its long half-life (~58 days), adverse effects may persist after discontinuation.

Drug Interactions

Amiodarone interacts with several classes of drugs, including:

• Beta-blockers and Calcium Channel Blockers: Additive effects can cause bradycardia.

• Warfarin: Increases INR; anticoagulant dose adjustment is often needed.

• Digoxin: Amiodarone increases digoxin levels.

• Simvastatin, Atorvastatin: Risk of myopathy.

• QT-Prolonging Agents: Risk of Torsades de Pointes.

Always inform your healthcare provider about all medications and supplements you are taking.

Storage Instructions

• Store below 25°C in a dry, cool place.

• Protect from light and moisture.

• Keep out of reach of children.

Frequently Asked Questions (FAQs)

Q1. Is AMIDRONE 100 safe for long-term use?

Amiodarone is effective for long-term rhythm control but requires regular monitoring due to potential organ toxicities.

Q2. Can I stop taking AMIDRONE 100 suddenly?

No. Discontinuation should be gradual and under medical supervision to prevent rebound arrhythmias.

Q3. How quickly does Amiodarone 100 mg work?

It may take several days to weeks to achieve full therapeutic effect, especially during the loading phase.

Q4. Can AMIDRONE 100 cause thyroid problems?

Yes. It may cause hypo- or hyperthyroidism; thyroid levels should be monitored during therapy.

Q5. Is it safe to drink alcohol while on Amiodarone?

Alcohol should be avoided as it can exacerbate cardiac issues and liver toxicity.

Conclusion

AMIDRONE 100 (Amiodarone Hydrochloride 100 mg) is a powerful antiarrhythmic medication used in the treatment of serious cardiac rhythm disorders. Due to its complex pharmacokinetics and potential for systemic side effects, its use is reserved for conditions where other therapies are ineffective. Regular follow-up, monitoring, and physician supervision are critical to its safe and effective use.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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