Understanding Trimetazidine 80mg: Uses, Dosage, and Side Effects

Introduction

TRIMETAZ CR 80 is a modified release formulation of trimetazidine 80 mg, developed to provide sustained therapeutic levels for improved patient compliance and optimal control of chronic stable angina pectoris. As a metabolic anti-ischemic agent, Trimetazidine offers a unique mechanism of action that works at the cellular level to enhance myocardial glucose utilization, especially under ischemic conditions.This high-quality product is manufactured by Steris Healthcare Pvt. Ltd., adhering to WHO-GMP standards.

What is Trimetazidine?

Trimetazidine is a metabolic agent used in cardiology primarily to manage chronic stable angina. It does not affect heart rate or blood pressure but works by optimizing cellular energy metabolism in ischemic cardiac tissue.

Trimetazidine 80 mg is particularly useful in patients who are not adequately controlled with conventional antianginal therapies like beta-blockers or calcium channel blockers.

Mechanism of Action (trimetazidine moa)

Trimetazidine works by selectively inhibiting the mitochondrial long-chain 3-ketoacyl coenzyme A thiolase (3-KAT) enzyme. This action:

• Enhances glucose oxidation over fatty acid metabolism

• Preserves ATP production under ischemic conditions

• Reduces intracellular acidosis and calcium overload

• Maintains cellular homeostasis and myocardial contractility

This unique trimetazidine moa helps maintain cardiac efficiency and protects against oxidative stress without altering hemodynamics.

Indications

TRIMETAZ CR 80 is indicated for the symptomatic treatment of chronic stable angina pectoris in adult patients inadequately controlled or intolerant to first-line antianginal therapies.

Other off-label or adjunctive uses include:

• Supportive treatment in ischemic heart disease

• Adjunct to therapy in vestibular disorders (e.g., tinnitus, vertigo in Ménière’s disease)

• Retinal circulation disorders (rarely)

Dosage and Administration

• Recommended Dose: One trimetazidine tab of 80 mg once daily with food

• Formulation: Trimetazidine hydrochloride modified release tablets provide 24-hour coverage with single dosing

• Special Populations:

  • Elderly patients: Monitor renal function before initiation

  • Renal impairment: Not recommended if creatinine clearance <30 mL/min

Clinical Benefits of Trimetazidine MR (Modified Release)

• Symptom Relief – Reduces angina attacks and nitrate use
• Energy Efficiency – Protects heart cells during ischemia
• Non-Hemodynamic – No effect on heart rate or blood pressure
• Once-Daily Convenience – Improves adherence and compliance
• Safe for Long-Term Use – Well-tolerated in chronic therapy

Trimetazidine Side Effects

Though generally well tolerated, some trimetazidine side effects may occur, including:

Common:

• Nausea

• Abdominal pain

• Dizziness

• Headache

Less Common / Serious:

• Parkinsonian symptoms (tremor, rigidity, gait disturbance)

• Sleep disturbances

• Rash or pruritus

• Thrombocytopenia (rare)

Discontinue use if neurological symptoms appear, especially in elderly patients.

Contraindications

Avoid use in:

• Patients with Parkinson’s disease or movement disorders

• Severe renal impairment (CrCl <30 mL/min)

• Known hypersensitivity to trimetazidine

Drug Interactions

Trimetazidine has no major known drug interactions, making it safe to combine with other cardiovascular medications, including:

• Beta-blockers

• Calcium channel blockers

• Nitrates

• Statins

• Antiplatelet drugs

However, patients with multiple comorbidities should be monitored regularly.

Storage Conditions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

Product Summary

FAQs – Trimetazidine Tablet

1. What is Trimetazidine 80 mg used for?

It is used to manage chronic stable angina pectoris in patients inadequately controlled by conventional therapies.

2. Is Trimetazidine a blood thinner or beta-blocker?

No, it is a metabolic antianginal. It does not lower blood pressure or thin the blood.

3. Can Trimetazidine 80 mg be used in elderly patients?

Yes, with renal function monitoring. Caution in those with movement disorders.

4. Is Trimetazidine taken before or after meals?

It is best taken after meals to minimize gastric discomfort.

5. How long should I take Trimetazidine?

It is generally used for long-term management of angina under physician supervision.

Conclusion

TRIMETAZ CR 80, containing trimetazidine 80 mg in a modified release formulation, is a well-tolerated and effective solution for patients with chronic stable angina. Its non-hemodynamic profile, once-daily dosing, and metabolic action make it a preferred add-on therapy in long-term cardiovascular care.Produced under stringent quality control by Steris Healthcare Pvt. Ltd., this trimetazidine tablet reflects the company’s commitment to innovative and affordable cardiac care.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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