Tacrolimus Capsules (1mg) . . .. . ..

Introduction
Tacrenolime 1 contains 1mg of tacrolimus, an immunosuppressive medication primarily used in organ transplant recipients to prevent the body from rejecting the transplanted organ. Tacrolimus is a potent calcineurin inhibitor that selectively targets T-lymphocytes, reducing immune response. This immunosuppressive property has made it a critical drug for both organ transplant patients and, in some cases, individuals with severe autoimmune skin disorders. Tacrenolime 1 is particularly valuable in maintaining the balance between immune suppression and patient safety.

Mechanism of Action
Tacrolimus works by inhibiting calcineurin, an enzyme critical to activating T-cells, a type of white blood cell responsible for immune response. By blocking calcineurin, tacrolimus helps prevent the activation of T-cells, thereby suppressing immune responses that can lead to organ rejection or inflammatory skin conditions. This suppression reduces the likelihood of the immune system attacking transplanted organs or causing severe flare-ups in autoimmune skin disorders.

Uses
Tacrenolime 1 serves multiple therapeutic purposes, from transplant support to treating dermatological conditions. Key uses include:

1. Prevention of Organ Rejection: Tacrolimus is widely used in kidney, liver, and heart transplant patients. By reducing immune activity, it prevents the body from rejecting the new organ, a critical component in the post-transplant recovery phase.
2. Management of Atopic Dermatitis: In some cases, Tacrenolime 1 is used off-label to manage severe, treatment-resistant atopic dermatitis. Tacrolimus has shown to reduce inflammation and itching in patients with this skin condition, especially when topical therapies fail.
3. Autoimmune Disorders: Tacrolimus is occasionally used for other autoimmune diseases, including lupus and rheumatoid arthritis, though these applications are less common. It has shown promising results in mitigating autoimmune responses by modulating T-cell activity.

Dosage
Tacrenolime 1 dosage varies depending on the patient’s condition, weight, and specific organ transplant requirements. Dosage guidelines typically involve starting with a standard dosage and adjusting based on therapeutic response and blood levels of the drug. Tacrolimus is available in both oral and injectable forms; the oral dosage should be consumed on an empty stomach for optimal absorption.

1. Organ Transplant Dosage: Dosage for organ transplant patients is generally divided into two daily doses, taken 12 hours apart. Initial doses might be higher immediately post-transplant to prevent acute rejection, and the dosage is gradually reduced.
2. Dermatological Dosage: For skin conditions, a topical form of tacrolimus is used. Oral administration is usually reserved for more severe, systemic cases under the close supervision of a dermatologist.
3. Missed Dosage and Overdose: If a dose is missed, it should be taken as soon as possible unless the next dose is due. Double-dosing is not recommended. In cases of overdose, patients must seek immediate medical assistance as overdose symptoms can include severe immune suppression, elevated blood pressure, and kidney complications.

Side Effects
As with most immunosuppressive drugs, Tacrenolime 1 has several potential side effects. Monitoring by a healthcare provider is essential, especially during the initial treatment phases.

• Common Side Effects: Patients may experience headaches, tremors, diarrhea, nausea, or high blood pressure. These side effects are typically mild but should be reported to a healthcare provider if they persist.
• Serious Side Effects: Tacrolimus has been associated with nephrotoxicity, which can lead to kidney damage if not monitored. Other severe side effects include increased susceptibility to infections, lymphoma, and high blood sugar levels.
• Long-Term Side Effects: Patients on prolonged tacrolimus therapy should be aware of the potential for liver and kidney toxicity, increased cancer risk, and long-term metabolic imbalances, such as hyperglycemia.

Safety Information
Tacrenolime 1 requires a careful balance between efficacy and minimizing side effects. Key safety precautions include:

1. Routine Monitoring: Regular blood tests are essential to monitor tacrolimus levels, kidney function, and blood sugar levels. This ensures that the dosage remains within therapeutic limits and minimizes the risk of organ damage.
2. Infection Risk: Due to its immunosuppressive nature, tacrolimus can make patients more susceptible to infections. Patients are advised to avoid close contact with sick individuals and maintain strict hygiene.
3. Avoiding Certain Foods and Medications: Patients are advised to avoid grapefruit and grapefruit juice, as they can alter tacrolimus levels in the blood, leading to potential toxicity. Also, certain medications, including NSAIDs and certain antibiotics, can interact adversely with tacrolimus.
4. Pregnancy and Breastfeeding: Tacrolimus may pose risks to pregnant or breastfeeding women. Women in these categories should consult with their healthcare provider before starting or continuing tacrolimus therapy.

Price of Tacrenolime 1 in India
The cost of Tacrenolime 1 (Tacrolimus 1mg) can vary based on the brand and purchase location. Generally, the price for a 1mg tacrolimus tablet ranges between ₹100 to ₹150 per tablet in India. Prices may vary, so checking with local pharmacies or online suppliers for the most accurate and current rates is advisable.

Frequently Asked Questions

1. Can Tacrenolime 1 be used for psoriasis?
Tacrolimus is sometimes used off-label for treating severe psoriasis, particularly in cases resistant to other treatments. However, it is important to use it under strict medical supervision.

2. How should Tacrenolime 1 be stored?
Tacrenolime 1 should be stored in a cool, dry place, away from direct sunlight and moisture. It is also essential to keep it out of reach of children, as it is a potent immunosuppressant.

3. Are there any dietary restrictions with Tacrenolime 1?
Yes, grapefruit and grapefruit juice should be avoided while taking tacrolimus as they can interfere with the drug’s metabolism, leading to potential toxicity.

4. What should be done if a dose is missed?
In the event of a missed dose, take it as soon as possible. If it’s nearly time for the next dose, skip the missed one and continue with the regular dosing schedule. Never double up on doses to make up for a missed one.

Conclusion
Tacrenolime 1, with its active ingredient tacrolimus, plays an indispensable role in managing organ transplant rejections and, in some cases, autoimmune disorders and severe dermatological conditions. Its potent immunosuppressive properties demand diligent medical supervision to manage dosage, minimize side effects, and ensure long-term safety. Tacrolimus has made a significant impact in the field of immunosuppression, enhancing patient outcomes and providing a reliable option for patients at risk of organ rejection. However, due to its powerful immune-modulating effects, it is essential for patients to adhere strictly to medical guidance, including regular blood monitoring and dietary precautions. Tacrenolime 1 remains a cornerstone medication for transplant patients and a selective option for individuals with autoimmune conditions. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline  ,  Sterisindia and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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