Pramipexole (0.125mg) & PRAMIXOLE 0.125 Tablet : Dosage, Side Effects, Precautions and warnings.....

PRAMIXOLE 0.125 is a trusted formulation containing Pramipexole 0.125 mg tablet, widely used in the treatment of neurological disorders such as Parkinson’s disease and Restless Legs Syndrome (RLS). This medication belongs to a group of medicines known as dopamine agonists, which help restore the balance of dopamine in the brain, a crucial neurotransmitter responsible for movement control and emotional responses.

With the increasing prevalence of movement disorders and growing awareness about effective management, Pramipexole tablets like PRAMIXOLE 0.125 have become essential in improving patients’ quality of life. Whether you are newly diagnosed or seeking a more stable routine for chronic management, this article will guide you through the complete benefits, side effects, uses, dosage, and more related to pramipexole 1.25 mg tablet.

What is PRAMIXOLE 0.125?

PRAMIXOLE 0.125 contains pramipexole dihydrochloride equivalent to pramipexole 1.25 mg. It is used primarily to treat Parkinson’s disease and Restless Legs Syndrome (RLS). This pramipexole tablet works by mimicking dopamine in the brain, which helps improve movement, reduce stiffness, and ease tremors.

Pramipexole Uses

The major pramipexole uses include:

1. Parkinson’s Disease

Parkinson’s is a progressive neurological disorder that affects movement. Pramipexole 1.25 mg tablet is commonly used either alone or with other medications to control symptoms like:

• Muscle stiffness

• Tremors

• Slowness of movement

• Poor balance or coordination

It’s particularly useful in early-stage Parkinson’s or when patients begin to experience "off" periods during levodopa therapy.

2. Restless Legs Syndrome (RLS)

RLS is a sleep-related movement disorder characterized by an uncontrollable urge to move the legs, usually due to uncomfortable sensations. Pramipexole tablets help reduce these symptoms and improve sleep quality.

3. Off-label Uses

Though not FDA-approved for these, some doctors may prescribe pramipexole tablets for:

• Depression (especially resistant cases)

• Fibromyalgia

• Bipolar disorder (adjunctive therapy)

• Tardive dyskinesia

How Does Pramipexole Work?

Pramipexole, the active ingredient in PRAMIXOLE 0.125, is a dopamine agonist. It binds to dopamine receptors in the brain, particularly D2 and D3 receptors, and mimics the action of natural dopamine.

Since Parkinson’s disease is associated with low dopamine levels, pramipexole tablets help improve the signaling between brain cells, allowing better control of body movements and reducing tremors and stiffness. In RLS, this mechanism relieves the sensations that cause the urge to move the legs.

Pramipexole Dosage and Administration

Always follow your doctor’s prescription. However, general dosage guidelines for pramipexole 1.25 mg tablet are as follows:

For Parkinson’s Disease:

• Starting dose: 0.125 mg three times a day

• Titration: Increased gradually every 5–7 days

• Maximum dose: Usually does not exceed 4.5 mg/day

For RLS:

• Typically taken once daily in the evening

• Starting dose: 0.125 mg, may increase to 0.25–0.5 mg depending on response

Important Notes:

• Take with or without food

• Swallow whole with water

• Do not suddenly stop taking the medicine

Pramipexole Side Effects

While pramipexole tablets are generally well-tolerated, they may cause some side effects. It's important to be aware of both common and serious side effects.

Common Side Effects:

• Nausea

• Dizziness or lightheadedness

• Drowsiness

• Insomnia

• Fatigue

• Constipation

• Dry mouth

Serious Side Effects:

• Hallucinations (especially in older adults)

• Compulsive behaviors (gambling, eating, shopping)

• Orthostatic hypotension (drop in blood pressure when standing)

• Muscle weakness

• Shortness of breath or swelling (rare)

If you experience any severe symptoms, contact your healthcare provider immediately.

Who Should Avoid Pramipexole 1.25 mg Tablet?

Do not take PRAMIXOLE 0.125 if you:

• Are allergic to pramipexole

• Have severe kidney disease (unless advised by your doctor)

• Are pregnant or breastfeeding without medical consultation

• Have a history of compulsive behavior or psychosis

Caution is also advised in patients with:

• Heart disorders

• Mental health conditions

• Sleep disorders (due to risk of sudden sleep attacks)

Drug Interactions

Certain medications can interact with pramipexole tablets, including:

• Antipsychotics (may reduce pramipexole’s effects)

• Sedatives and alcohol (increase drowsiness)

• Blood pressure medications (may increase risk of low BP)

• Levodopa (may enhance side effects like hallucinations)

Always inform your doctor about any ongoing medication or supplement you are using.

Pramipexole 1.25 mg Tablet – Precautions

• Driving or operating machinery: Be cautious as this medicine can cause sleep attacks or dizziness.

• Kidney function monitoring: Required for long-term use.

• Regular checkups: Important to evaluate symptoms, blood pressure, and possible psychiatric effects.

• Gradual discontinuation: Don’t stop taking the medication abruptly to avoid withdrawal symptoms or worsening of Parkinson’s symptoms.

Tips for Safe and Effective Use

• Take your dose at the same time every day to maintain stable drug levels.

• Stand up slowly to prevent dizziness.

• Maintain hydration and a healthy diet to combat constipation or fatigue.

• Track unusual behaviors (such as gambling or binge eating) and report them.

• Ensure family members are aware of potential psychiatric side effects.

Availability & Pricing in India

PRAMIXOLE 0.125, containing pramipexole 1.25 mg tablet, is available in most medical stores across India. The price may vary depending on the brand, quantity, and region.

You can also buy PRAMIXOLE 0.125 from SterisOnline, one of the most trusted and reliable pharmaceutical platforms in India. They offer genuine products, competitive pricing, and doorstep delivery.

Why Choose PRAMIXOLE 0.125 from SterisOnline?

• Trusted pharmaceutical brand in India

• Assured quality and genuine medicine

• Easy ordering and doorstep delivery

• Excellent customer support

Frequently Asked Questions (FAQs)

1. Is pramipexole 1.25 mg tablet safe for long-term use?

Yes, pramipexole tablets are often prescribed for long-term use in Parkinson’s and RLS. Regular monitoring by your doctor is essential.

2. Can I take pramipexole with food?

Yes, it can be taken with or without food. Taking it with food may reduce nausea.

3. What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. Skip it if it’s almost time for your next dose. Do not double up to make up for the missed dose.

4. Can pramipexole cause hallucinations?

Yes, especially in older adults or those on higher doses. If hallucinations occur, consult your doctor for possible dose adjustment.

5. How quickly does pramipexole work?

Improvement in symptoms may be noticed within a few days to weeks, depending on the condition being treated and the individual’s response.

Conclusion

PRAMIXOLE 0.125, featuring pramipexole 1.25 mg tablet, is a reliable and effective option for treating Parkinson’s disease and Restless Legs Syndrome. It significantly enhances patients’ quality of life by reducing motor symptoms and improving sleep.

While it has some side effects, most are manageable with careful use and regular medical supervision. The medication must be taken exactly as prescribed, and changes should always be done under medical advice.

If you're seeking a dependable source to purchase pramipexole tablets, consider buying from SterisOnline, a trusted platform in India known for providing authentic pharmaceutical products.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

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