PAFAGOLD M 1000 Tablet- View Uses, Side Effects, Dosage, Mechanism of action...

Introduction

PAFAGOLD M 1000 is a fixed-dose combination oral antidiabetic medication composed of Dapagliflozin 10 mg and Metformin Hydrochloride 1000 mg (sustained release). This powerful combination is indicated for adults with Type 2 Diabetes Mellitus (T2DM) who require better glycemic control than achieved with either drug alone.It offers the dual benefits of reducing blood glucose through both insulin-dependent and insulin-independent mechanisms, while also helping manage weight and improving cardiovascular outcomes.

PAFAGOLD M 1000 Composition Details

Dapagliflozin 10 mg

• Class: SGLT2 Inhibitor (Sodium-Glucose Co-Transporter 2 Inhibitor)

• Mechanism: Reduces glucose reabsorption in the kidneys, promoting urinary glucose excretion.

• Benefits:

  • Aids in weight loss

  • Lowers blood pressure

  • Reduces the risk of heart failure hospitalization

  • Works independently of insulin action

Metformin Hydrochloride 1000 mg (SR)

• Class: Biguanide

• Mechanism: Decreases hepatic glucose production and increases insulin sensitivity.

• Benefits:

  • First-line therapy in diabetes

  • Promotes glycemic control without causing weight gain

  • Improves fasting blood glucose and HbA1c levels

Uses of PAFAGOLD M 1000

PAFAGOLD M 1000 is used for:

• Managing Type 2 Diabetes Mellitus in adults, particularly:

  • When monotherapy is insufficient

  • As an adjunct to diet and exercise

• Reducing HbA1c levels and maintaining long-term glycemic control

• Providing cardiovascular protection in high-risk diabetic patients

• Supporting weight loss and blood pressure reduction

How PAFAGOLD M 1000 Works

This dual-ingredient therapy works through complementary mechanisms:

• Dapagliflozin 10 mg tablet enhances renal glucose excretion by inhibiting SGLT2 receptors in the proximal tubules of the kidney.

• Metformin 1000 mg reduces liver glucose production and improves peripheral insulin sensitivity.

Together, they offer superior glycemic control with added cardiometabolic benefits, making PAFAGOLD M 1000 a robust option in modern diabetes management.

Dosage and Administration

• Recommended Dose: One tablet daily or as prescribed by the physician.

• Route: Oral

• Best Time: With food to reduce gastrointestinal discomfort (due to Metformin).

• Important: Do not crush or chew sustained-release tablets.

Individualized dosing may be required depending on patient’s renal function, HbA1c levels, and tolerability.

Dapagliflozin 10 mg Side Effects

While Dapagliflozin 10 mg tablets are well-tolerated, some patients may experience:

• Common Side Effects:

  • Increased urination

  • Genital fungal infections (especially in females)

  • Mild dehydration

  • Urinary tract infections

• Rare Side Effects:

  • Ketoacidosis (though rare in Type 2 diabetes)

  • Increased creatinine in susceptible individuals

  • Hypotension in patients with low blood pressure

Metformin Side Effects

• Gastrointestinal symptoms like nausea, bloating, or diarrhea

• Vitamin B12 deficiency (long-term use)

• Rare risk of lactic acidosis (in renal dysfunction)

Precautions and Warnings

• Not recommended in patients with type 1 diabetes or diabetic ketoacidosis

• Caution in renal impairment; regular monitoring of eGFR is advised

• Avoid excessive alcohol intake

• Inform your physician if you are pregnant or breastfeeding

• Ensure adequate hydration to prevent dehydration and related side effects

Drug Interactions

• Diuretics: May increase the risk of volume depletion

• Insulin or insulin secretagogues: May enhance hypoglycemic risk

• Cimetidine and other medications that affect renal function should be used cautiously with Metformin

Advantages of PAFAGOLD M 1000 by Steris Healthcare

• Combines two proven and complementary mechanisms for optimal glucose control

• Sustained-release Metformin improves GI tolerability

• SGLT2 inhibitor offers heart and kidney protection

• Backed by Steris Healthcare's commitment to quality and affordability

• Manufactured in WHO-GMP certified facilities with pan-India availability

Frequently Asked Questions (FAQs)

Q1. What is Dapagliflozin 10 mg used for?

Dapagliflozin 10 mg is used to lower blood sugar in people with Type 2 diabetes and offers added benefits like weight loss, blood pressure reduction, and heart failure risk reduction.

Q2. Can PAFAGOLD M 1000 cause low blood sugar?

It generally does not cause hypoglycemia unless combined with insulin or sulfonylureas.

Q3. Is Metformin 1000 mg safe for long-term use?

Yes, but periodic monitoring of kidney function and Vitamin B12 levels is recommended.

Q4. How quickly does PAFAGOLD M 1000 start working?

Most patients begin seeing results within a few days to 1–2 weeks, with significant HbA1c reduction observed over 3 months.

Q5. Can I use PAFAGOLD M 1000 for weight loss?

While it is not a weight-loss drug, Dapagliflozin can contribute to modest weight loss in diabetic patients as a secondary benefit.

Conclusion

PAFAGOLD M 1000 is an advanced oral antidiabetic formulation offering the powerful combination of Dapagliflozin 10 mg and Metformin Hydrochloride 1000 mg to address the multifaceted challenges of Type 2 Diabetes Mellitus. With proven efficacy, cardiovascular benefits, and an excellent safety profile, it is the ideal choice for patients seeking enhanced glycemic control with added health advantages. Choose Steris Healthcare’s PAFAGOLD M 1000 for a healthier, balanced life with diabetes.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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