Glimepiride (2mg), Metformin SR (500mg) & Pioglitazone (15mg) - Explore...

Introduction

SEIZMET GP 2 is a powerful oral anti-diabetic combination formulated for effective blood sugar control in Type 2 Diabetes Mellitus (T2DM). It combines the synergistic effects of Glimepiride 2 mg, Metformin SR 500 mg, and Pioglitazone 15 mg—targeting insulin secretion, insulin sensitivity, and glucose utilization through multiple mechanisms. This combination is widely prescribed for patients who require more than one agent to maintain optimal glycemic levels.

Composition

Each film-coated tablet of SEIZMET GP 2 contains:

• Glimepiride – 2 mg

• Metformin Hydrochloride SR – 500 mg

• Pioglitazone Hydrochloride – 15 mg

Mechanism of Action

1. Glimepiride 2 mg: A sulfonylurea that stimulates insulin secretion from pancreatic beta cells.

2. Metformin SR 500 mg: A biguanide that reduces hepatic glucose production and increases insulin sensitivity.

3. Pioglitazone 15 mg: A thiazolidinedione that enhances peripheral glucose uptake by improving insulin action in muscle and fat tissues.

This triple therapy ensures comprehensive glycemic control across fasting and postprandial states.

Indications & Uses

SEIZMET GP 2 is indicated for:

• Management of Type 2 Diabetes Mellitus (T2DM)

• Patients uncontrolled with monotherapy or dual therapy

• Individuals with insulin resistance or obesity-related diabetes

• Prevention of microvascular complications like neuropathy, nephropathy, and retinopathy

Benefits of SEIZMET GP 2

• Triple-action control on fasting and postprandial glucose
• Lowers HbA1c effectively
• Helps manage insulin resistance
• Suitable for overweight or obese diabetic patients
• SR (Sustained Release) form of Metformin ensures better GI tolerance

Dosage & Administration

• Recommended Dose: One tablet once daily with breakfast or the first main meal

• Dose may be adjusted by a healthcare provider based on blood glucose levels and patient response

• Do not crush or chew the tablet

Important: Regular blood sugar monitoring and follow-ups are essential for dose titration.

Side Effects

Some commonly observed side effects include:

• Hypoglycemia (especially if meal is skipped)

• Nausea, diarrhea (due to Metformin SR)

• Weight gain or edema (rare, due to Pioglitazone)

• Headache or dizziness

Serious side effects like lactic acidosis (from Metformin) are rare but require immediate attention.

Precautions

• Not suitable for Type 1 diabetes or diabetic ketoacidosis

• Use with caution in patients with renal, hepatic, or cardiac disorders

• Avoid in pregnancy and lactation unless prescribed

• Routine liver function and kidney function tests are advised

Storage Instructions

• Store below 30°C in a dry place

• Keep out of reach of children

• Protect from moisture and direct sunlight

Why Choose SEIZMET GP 2 by Steris Healthcare?

• Scientifically balanced triple combination

• WHO-GMP certified manufacturing

• Backed by consistent clinical results

• Trusted by endocrinologists and diabetologists across India

FAQs

1. Can SEIZMET GP 2 cause hypoglycemia?

Yes, especially if taken without food. Always take it with meals to minimize the risk.

2. Is Metformin SR 500 mg safe for the stomach?

Yes, the SR (Sustained Release) version reduces GI side effects commonly seen with regular Metformin.

3. Can I take this with insulin?

Only under strict medical supervision. Combining insulin with SEIZMET GP 2 increases the risk of low blood sugar.

Conclusion

SEIZMET GP 2 offers a comprehensive solution for Type 2 Diabetes by combining three powerful anti-diabetic agents in one convenient tablet. It helps patients achieve stable blood sugar levels, reduce complications, and maintain a better quality of life. For long-term diabetic management that targets multiple pathways, SEIZMET GP 2 by Steris Healthcare is the smart and trusted choice.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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