Glibenclamide (5mg), Metformin HCI (500mg) & GLIBEMIDE FORTE : Tablet - Steris Healthcare PVT LTD………

Introduction

GLIBEMIDE FORTE is a fixed-dose combination of Glibenclamide 5 mg and Metformin Hydrochloride 500 mg, used for effective blood glucose control in patients with Type 2 Diabetes Mellitus. This dual therapy targets both insulin resistance and pancreatic beta-cell function, offering synergistic glucose-lowering benefits.

Therapeutic Class

• Glibenclamide (5 mg): A sulfonylurea that stimulates insulin secretion from pancreatic beta cells

• Metformin Hydrochloride (500 mg): A biguanide that decreases hepatic glucose production and improves insulin sensitivity

Indications and Uses

GLIBEMIDE FORTE is indicated for:

• Management of Type 2 Diabetes Mellitus in adults, especially when monotherapy is inadequate

• As an adjunct to diet and exercise to improve glycemic control

• Suitable for patients with moderate hyperglycemia not controlled by metformin or glibenclamide alone

Mechanism of Action

Glibenclamide enhances insulin secretion by acting on sulfonylurea receptors in pancreatic beta cells.
Metformin works by:

• Reducing hepatic glucose output

• Enhancing peripheral glucose uptake

• Lowering intestinal absorption of glucose

Together, they offer both fasting and postprandial glycemic control.

Dosage and Administration

• Typical Dose: One tablet once or twice daily with meals

• Dosage should be individualized based on patient’s blood glucose levels

• Not to be used in Type 1 Diabetes or diabetic ketoacidosis

Note: Always follow physician instructions. Dose adjustments may be required for elderly or renally impaired patients.

Glibenclamide Tablets IP 5 mg Uses

• Lowering blood sugar levels in patients with non-insulin-dependent diabetes

• Preventing diabetes-related complications like neuropathy, nephropathy, and retinopathy

• Used in fixed-dose combinations like GLIBEMIDE FORTE for synergistic action

Contraindications

• Hypersensitivity to Glibenclamide, Metformin, or any sulfonylurea

• Severe renal impairment (eGFR <30 ml/min)

• Liver disease, heart failure, or conditions associated with hypoxia

• History of lactic acidosis or diabetic ketoacidosis

• Alcohol abuse

Warnings and Precautions

• Monitor kidney function periodically

• Watch for signs of lactic acidosis (nausea, vomiting, fatigue, rapid breathing)

• Caution in elderly and malnourished patients

• Avoid excessive alcohol intake

• Not for use in pregnancy or breastfeeding unless prescribed

Common Side Effects

• Glibenclamide: Hypoglycemia, weight gain, skin rash

• Metformin: Gastrointestinal upset (nausea, diarrhea, abdominal pain), metallic taste

• Rare but serious: Lactic acidosis (life-threatening), especially in renal impairment

Drug Interactions

• Beta-blockers may mask hypoglycemia symptoms

• NSAIDs, ACE inhibitors, and diuretics may increase the risk of hypoglycemia or renal dysfunction

• Avoid concurrent alcohol use

• Use caution with corticosteroids, thyroid hormones, and certain antibiotics

Monitoring Parameters

• Fasting and postprandial blood sugar

• HbA1c (glycated hemoglobin) every 3 months

• Renal function tests (Serum creatinine, eGFR)

• Liver function if on long-term therapy

• Signs of hypoglycemia or lactic acidosis

Storage Information

• Store in a cool, dry place below 25 degrees Celsius

• Keep away from moisture and direct sunlight

• Keep out of reach of children

Frequently Asked Questions (FAQs)

Q1. What is Glibenclamide 5 mg used for?
Glibenclamide 5 mg is used to stimulate insulin release in people with Type 2 diabetes, helping to lower blood sugar levels.

Q2. What are the benefits of combining Glibenclamide and Metformin?
The combination targets both insulin secretion and insulin resistance, offering better control of blood glucose than either drug alone.

Q3. Is GLIBEMIDE FORTE safe for long-term use?
Yes, if taken under medical supervision with regular monitoring, this combination can be safely used long-term.

Q4. Can GLIBEMIDE FORTE cause hypoglycemia?
Yes, Glibenclamide may cause low blood sugar, especially if meals are skipped. Patients should be educated about recognizing and managing hypoglycemia.

Q5. Should this tablet be taken with or without food?
Always take GLIBEMIDE FORTE with meals to minimize gastrointestinal side effects and reduce the risk of hypoglycemia.

Conclusion

GLIBEMIDE FORTE, combining Glibenclamide 5 mg and Metformin 500 mg, offers a powerful and synergistic approach to managing Type 2 Diabetes. Manufactured by Steris Healthcare with WHO GMP standards, it ensures efficacy, safety, and affordability. This fixed-dose therapy is ideal for patients needing dual action on both insulin secretion and resistance.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW