Cynoserine 250: Effective Treatment for MDR-TB and Resistant Infections

Introduction

CYNOSERINE 250 is a potent anti-tuberculosis medication that contains Cycloserine IP 250 mg, used primarily as a second-line therapy in treating multidrug-resistant tuberculosis (MDR-TB) and other mycobacterial infections. Known for its ability to penetrate cerebrospinal fluid, it is also effective in TB meningitis.

Composition:

• Cycloserine IP – 250 mg

• Brand Name: CYNOSERINE 250

• Dosage Form: Hard Gelatin Capsule / Tablet

What is CYNOSERINE 250?

CYNOSERINE 250 is a formulation of Cycloserine 250mg, a broad-spectrum antibiotic that works by inhibiting bacterial cell wall synthesis. It is reserved for resistant or complicated tuberculosis cases and is typically used in combination with other anti-TB medications as per Revised National Tuberculosis Control Program (RNTCP) or WHO guidelines.

Cycloserine 250mg Tablet / Capsule Uses:

• MDR-TB (Multidrug-Resistant Tuberculosis)

• XDR-TB (Extensively Drug-Resistant Tuberculosis)

• Tuberculous Meningitis

• Other Mycobacterial Infections

• Nontuberculous Mycobacteria (NTM) (off-label)

How Cycloserine Works:

Cycloserine inhibits two crucial enzymes—alanine racemase and D-alanine-D-alanine ligase—which are essential for bacterial cell wall synthesis. This results in the disruption of bacterial growth and eventually their destruction.

Dosage of Cycloserine 250mg:

• Adults: Typically, 250 mg twice daily (500 mg/day), increasing up to 750–1000 mg/day in divided doses under strict medical supervision.

• Always taken with food to reduce gastrointestinal discomfort.

• Close monitoring of serum levels and patient neuropsychological status is essential.

Note: Dosage should be tailored based on renal function, patient weight, and therapeutic drug monitoring.

Cycloserine Side Effects:

Common Side Effects:

• Drowsiness

• Dizziness

• Headache

• Rash

• Gastrointestinal discomfort

Serious Side Effects:

• Neurotoxicity (confusion, depression, psychosis, seizures)

• Peripheral neuropathy

• Speech difficulties or tremors

Caution: Regular neurological assessments are necessary, especially at higher doses.

Precautions:

• Neurotoxicity Risk: Monitor mental status regularly.

• Avoid in patients with history of epilepsy, alcohol abuse, or psychiatric illness.

• Use cautiously in renal impairment—requires dose adjustment.

• Pregnancy & Lactation: Use only if absolutely necessary.

Drug Interactions:

• Increased neurotoxic effects with isoniazid, ethionamide, alcohol, or psychiatric medications.

• Avoid with medications lowering the seizure threshold (e.g., fluoroquinolones, bupropion).

Monitoring Guidelines:

• Serum drug levels

• Liver and renal function

• Mental health and neurological status

FAQs – CYNOSERINE 250 (Cycloserine 250mg)

Q1. What is CYNOSERINE 250 used for?

A: CYNOSERINE 250 is used to treat multidrug-resistant tuberculosis (MDR-TB) and tuberculous meningitis, often in combination with other anti-TB drugs.

Q2. Is Cycloserine 250mg safe?

A: Yes, under strict medical supervision and regular monitoring for neurotoxicity. Vitamin B6 (pyridoxine) is often co-administered to reduce side effects.

Q3. How should CYNOSERINE 250 be taken?

A: Usually 250 mg twice a day with meals. Do not skip doses and follow your doctor’s prescription exactly.

Q4. Can Cycloserine 250mg capsule be used alone?

A: No. It should only be used as part of a combination anti-TB regimen to prevent resistance and improve outcomes.

Q5. What are the alternatives if Cycloserine causes side effects?

A: Your doctor may adjust the dose, switch to another second-line agent, or add supportive therapy like pyridoxine (Vitamin B6).

Conclusion:

CYNOSERINE 250 (Cycloserine 250mg tablet/capsule) is a critical component in the fight against drug-resistant tuberculosis. It must be used cautiously under medical supervision due to its potential neurological side effects. However, with the right monitoring and support, it offers significant benefit in tackling complex TB infections. Choose CYNOSERINE 250 for trusted, targeted MDR-TB management.

About The Company

Steris Healthcare Pvt Ltd, widely recognized as Sterispharma, was established in February 2018 by a team of seasoned experts from the pharmaceutical sector. Based in Navi Mumbai, the company is proudly certified by WHO, GMP, and ISO, underscoring its unwavering commitment to quality and patient safety. Sterispharma is driven by a mission to make affordable, premium-quality medicines accessible throughout India, adhering strictly to WHO-recommended standards. Through its user-friendly online pharmacy platforms, customers can effortlessly order medications with home delivery services.

Sterispharma boasts an extensive portfolio of healthcare solutions, ranging from treatments for rare diseases to essential everyday healthcare needs. Their comprehensive product lineup addresses multiple therapeutic areas including Cardiology, Asthma, Respiratory Disorders, Nasal Care, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infective/Antibiotic Therapy, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medications are easily available for online purchase through their official websites — Sterisonline, Sterisindia, and Sterispharma — offering a seamless and reliable healthcare experience.

For further information 

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