Comprehensive Guide to Danazol (200mg) for Effective Treatment

Danazol 200

Danazol 200, available as DANOZOLIS 200 from Steris Healthcare, is a synthetic hormone used to treat conditions like endometriosis, fibrocystic breast disease, and hereditary angioedema. By modulating hormone levels, it helps manage chronic pain, swelling, and menstrual irregularities effectively. This article explores its composition, uses, working mechanism, and key safety information.

What is Danazol 200 (DANOZOLIS 200)?

Danazol 200 is a synthetic steroid derived from ethisterone, primarily used for treating hormone-sensitive conditions such as endometriosis, fibrocystic breast disease, and hereditary angioedema. It works by altering hormone levels in the body, especially by suppressing the pituitary-ovarian axis, which reduces estrogen production in females and stabilizes immune responses.DANOZOLIS 200, manufactured by Steris Healthcare, delivers high-quality Danazol in a precise 200 mg formulation, ensuring optimal therapeutic effectiveness in managing chronic gynecological and hematological conditions.

Composition of DANOZOLIS 200

Each tablet of DANOZOLIS 200 contains:

• Danazol 200 mg (Active Ingredient)

• Excipients: QS (as per standard formulation for oral tablet delivery)

Danazol 200 Uses

Danazol 200 is primarily indicated in the treatment of:

1. Endometriosis

Danazol helps reduce the growth of endometrial tissue by suppressing ovarian function and estrogen production, thereby relieving symptoms like pelvic pain and menstrual irregularities.

2. Fibrocystic Breast Disease

It reduces breast pain and tenderness associated with benign breast lumps by altering hormonal influences on breast tissue.

3. Hereditary Angioedema

Danazol 200 increases the level of C1 esterase inhibitor in the blood, thereby preventing swelling episodes in patients with hereditary angioedema.

4. Menorrhagia (Heavy Menstrual Bleeding)

It can help reduce excessive menstrual bleeding by modulating hormonal levels.

Danazol 200 Uses in Hindi (डैनाज़ोल 200 के उपयोग)

डैनाज़ोल 200 टैबलेट का उपयोग निम्नलिखित स्थितियों के इलाज में किया जाता है:

• एंडोमेट्रिओसिस (गर्भाशय की परत का असामान्य विकास)

• फाइब्रोसिस्टिक स्तन रोग (छाती में गांठ और दर्द)

• वंशानुगत एंजियोएडेमा (त्वचा की सूजन की बीमारी)

• अत्यधिक मासिक धर्म रक्तस्राव

Mechanism of Action: How Does Danazol 200 Work?

Danazol 200 works through multiple mechanisms:

• Inhibits Gonadotropins (LH and FSH): By suppressing luteinizing hormone (LH) and follicle-stimulating hormone (FSH), Danazol prevents ovulation and reduces estrogen levels.

• Weak Androgenic Effect: It has mild androgenic activity that antagonizes the effects of estrogen on tissues.

• Immunomodulatory Action: In hereditary angioedema, it increases C1-inhibitor protein synthesis to control swelling episodes.

These actions collectively reduce pain, inflammation, and hormonal imbalances in various hormone-dependent conditions.

Danazol 200 Dosage and Administration

• Typical Dosage: 200 mg to 800 mg per day, divided into 2-4 doses depending on the severity of the condition.

• Route: Oral, with or without food.

• Treatment Duration: Typically 3 to 6 months for gynecological conditions; long-term use may be needed for hereditary angioedema.

Always follow your physician’s prescription and dosage instructions carefully.

Side Effects of Danazol 200

While Danazol 200 is effective, it may cause side effects, especially with prolonged use.

Common Side Effects:

• Weight gain

• Acne or oily skin

• Menstrual disturbances (e.g., amenorrhea)

• Hot flashes

• Voice deepening (irreversible in some cases)

• Increased hair growth (hirsutism)

Serious Side Effects (Seek medical help):

• Liver function abnormalities

• Mood changes or depression

• Pelvic pain or abdominal bloating

• Signs of masculinization (e.g., enlarged clitoris)

Precautions Before Using Danazol 200

Do not use if:

• You are pregnant or planning pregnancy

• You have severe liver, kidney, or heart disease

• You have a history of blood clots or stroke

• You are breastfeeding

Use with caution if:

• You have a history of migraines or seizures

• You are diabetic

• You are on long-term corticosteroid therapy

Pregnancy Category X: Danazol is contraindicated in pregnancy due to its masculinizing effects on the fetus.

Drug Interactions of Danazol 200

Danazol may interact with several medications. Inform your doctor if you are taking:

• Anticoagulants (e.g., warfarin) – Danazol may enhance the effect.

• Anti-diabetic drugs – It may increase blood sugar levels.

• Cyclosporine or Tacrolimus – Increased risk of kidney toxicity.

• Carbamazepine or Phenytoin – Altered plasma levels and effect.

Danazol 200 Tablet Uses in Hindi (डैनाज़ोल टैबलेट के उपयोग हिंदी में)

डैनाज़ोल टैबलेट का उपयोग महिलाओं में हार्मोन-संबंधी रोगों के इलाज के लिए किया जाता है। यह अंडाशय से एस्ट्रोजन हार्मोन के उत्पादन को कम करके एंडोमेट्रिओसिस और मासिक धर्म की समस्याओं में राहत देता है। साथ ही यह एंजियोएडेमा के इलाज में भी मदद करता है।

Why Choose DANOZOLIS 200 by Steris Healthcare?

• High Purity API: Assured potency and bioavailability

• WHO-GMP Certified Manufacturing

• Consistent Therapeutic Outcomes

• Backed by Pharmacovigilance Support

• Affordably Priced Without Compromising Quality

Steris Healthcare is a trusted name in the pharmaceutical industry, offering reliable, evidence-backed formulations across multiple therapeutic areas.

FAQs About Danazol 200 (DANOZOLIS 200)

Q1. Is Danazol 200 safe during pregnancy?

No, Danazol is contraindicated in pregnancy due to the risk of fetal abnormalities, especially masculinization of a female fetus.

Q2. Can Danazol 200 cause voice changes?

Yes, voice deepening is a possible side effect and may be irreversible in some cases.

Q3. How long can I take Danazol 200?

Treatment typically lasts 3 to 6 months, depending on the indication. Long-term use requires monitoring liver function and hormone levels.

Q4. Can Danazol be used for male patients?

It is rarely used in males but may be considered in specific androgen-deficient conditions under specialist guidance.

Q5. What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it’s near the time for the next dose, skip the missed one. Do not double dose.

Conclusion

Danazol 200 (DANOZOLIS 200) is a powerful therapeutic option for managing hormone-driven conditions such as endometriosis, fibrocystic breast disease, and hereditary angioedema. With a proven track record of efficacy and consistent quality from Steris Healthcare, DANOZOLIS 200 provides reliable symptom relief for chronic, debilitating disorders. However, its use should be closely monitored by a healthcare provider due to its potential side effects and hormonal impact.

For best results, always consult your physician before starting Danazol 200 and adhere to regular follow-ups during therapy.