DANOZOLIS 200

Danazol 200mg is a synthetic steroid derived from ethisterone, classified pharmacologically as an androgen derivative with weak androgenic, anabolic, and antiestrogenic properties. It has been a well-established therapeutic option for several decades in the management of specific hormone-related and inflammatory conditions where suppression of ovarian hormone production is clinically beneficial.

Under the brand name Danozolis 200, manufactured by Steris Healthcare, this formulation is prescribed by gynecologists, endocrinologists, and immunologists for a defined set of indications where its unique hormonal-suppressive and anti-inflammatory actions provide meaningful symptom relief.

Product Information

Why It's Important

Endometriosis affects a significant proportion of women of reproductive age in India and globally, often causing debilitating pelvic pain, heavy bleeding, and fertility challenges that can severely impact quality of life. For decades, Danazol has remained a clinically important treatment option, particularly in cases where other hormonal therapies such as GnRH agonists or combined oral contraceptives are not suitable or have proven insufficient.

Similarly, hereditary angioedema is a rare but potentially life-threatening genetic condition where sudden, severe swelling episodes — sometimes involving the airway — can occur without warning. Danazol's ability to increase levels of C1 esterase inhibitor makes it one of the few effective prophylactic options available for reducing the frequency and severity of these attacks, offering patients meaningful protection against a condition that can otherwise be unpredictable and dangerous.

For fibrocystic breast disease, Danazol offers an important non-surgical option for women experiencing significant cyclical breast pain and lumpiness that interferes with daily life, particularly when more conservative measures have not provided adequate relief.

The clinical importance of a reliable, consistently manufactured formulation like Danozolis 200 is particularly relevant here, given that Danazol therapy often requires sustained treatment over several months, and consistent bioavailability batch-to-batch is essential for predictable symptom control. Steris Healthcare's WHO-GMP and ISO 9001:2018 certified manufacturing standards support this consistency for patients on long-term therapy.

Key Benefits 

What Are the Benefits of Danazol 200?

Danazol 200mg, as formulated in Danozolis 200, offers several clinically meaningful advantages:

• Effective suppression of endometrial tissue activity: By reducing estrogen production and directly acting on endometrial tissue, Danazol helps shrink endometriotic lesions and reduce associated pelvic pain over the course of treatment.
• Reduction in hereditary angioedema attack frequency: Danazol has demonstrated efficacy in raising C1 esterase inhibitor and C4 complement levels, meaningfully reducing the frequency and severity of angioedema episodes in long-term prophylactic use.
• Relief from fibrocystic breast symptoms: Clinical use has shown Danazol to be effective in reducing breast nodularity, tenderness, and cyclical pain associated with fibrocystic breast disease.
• Oral convenience: As an oral capsule, Danazol offers a non-invasive treatment route compared to injectable hormonal therapies, supporting easier long-term adherence.
• Well-characterized long-term clinical experience: Decades of clinical use have generated a well-understood efficacy and safety profile, helping specialists make informed treatment decisions for appropriate candidates.
• Alternative for patients unsuitable for other hormonal therapies: For patients who cannot tolerate or do not respond adequately to GnRH agonists or combined hormonal contraceptives, Danazol offers a distinct mechanism-based alternative.
• Trusted manufacturing standards: Danozolis 200 is manufactured by Steris Healthcare, a WHO-GMP and ISO 9001:2018 certified pharmaceutical company, ensuring consistent potency and quality across every batch — important for a therapy often used over extended treatment courses.

Side Effects 

Because Danazol has androgenic and antiestrogenic properties, its side effect profile is distinct from many other hormonal therapies. Common side effects include:

• Weight gain
• Acne and oily skin
• Mild hirsutism (increased facial or body hair growth)
• Menstrual irregularities, including amenorrhea (absence of periods) during treatment
• Hot flushes and vaginal dryness
• Muscle cramps
• Headache
• Mood changes, including irritability
• Voice changes (deepening), particularly with prolonged use

Most mild androgenic side effects are dose-dependent and tend to be more noticeable with higher doses or longer treatment duration; they are generally monitored closely by the prescribing physician throughout therapy.

Precautions & Warnings

Before starting Danazol 200, patients and prescribers should carefully consider the following precautions:

• Pregnancy: Danazol is contraindicated in pregnancy due to the risk of virilization of a female fetus. Effective non-hormonal contraception is required during treatment, as Danazol can also interfere with the reliability of hormonal contraceptives.
• Liver Disease: Should not be used in patients with significant hepatic impairment, given the drug's association with liver enzyme elevation and rare hepatotoxicity.
• Cardiovascular and Renal Disease: Should be used cautiously in patients with pre-existing cardiac, renal, or hepatic dysfunction due to the risk of fluid retention.
• Breastfeeding: Danazol is generally not recommended during breastfeeding due to potential effects on the infant.
• Androgen-Sensitive Conditions: Should be avoided in patients with androgen-dependent tumors or a history of such conditions.
• Diabetes: Danazol may affect glucose tolerance, so blood sugar should be monitored closely in diabetic patients.
• Migraine or Epilepsy: Caution advised, as fluid retention associated with Danazol may worsen these conditions in susceptible individuals.
• Drug Interactions: Caution is required when co-administering with anticoagulants (Danazol can enhance the effect of warfarin), insulin or oral hypoglycemics, carbamazepine, and certain statins, due to potential interaction effects.
• Regular Monitoring: Periodic liver function tests and clinical assessment are recommended throughout the course of treatment, particularly with extended use.

Mechanism of Action 

Danazol 200mg exerts its therapeutic effects through a multifaceted hormonal mechanism:

1. Suppression of the Hypothalamic-Pituitary-Ovarian Axis: Danazol inhibits the pituitary release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), reducing ovarian estrogen and progesterone production, which creates a relatively hypoestrogenic, hyperandrogenic hormonal environment.
2. Direct Action on Endometrial and Breast Tissue: Danazol binds directly to androgen, progesterone, and glucocorticoid receptors in endometrial and breast tissue, contributing to atrophy of endometriotic implants and reduction in breast tissue nodularity independent of its systemic hormonal suppression.
3. Increased Hepatic Synthesis of C1 Esterase Inhibitor: In hereditary angioedema, Danazol stimulates hepatic production of C1 esterase inhibitor and complement component C4, addressing the underlying complement pathway dysfunction responsible for angioedema attacks.
4. Weak Androgenic and Anabolic Activity: Danazol's mild androgenic activity contributes both to its therapeutic effects and to its characteristic androgenic side effects, such as acne, weight gain, and voice changes.
5. Sex Hormone-Binding Globulin (SHBG) Modulation: Danazol reduces SHBG levels, which can increase free testosterone availability, further contributing to its androgenic effect profile.

Frequently Asked Questions 

1. Where can I buy Danazol 200 mg online?
You can purchase Danazol 200 mg through licensed online pharmacies or authorized pharmaceutical suppliers. Verify the manufacturer, strength, batch number, expiry date, and packaging before purchasing.

2. What is the price of Danazol 200 mg?
The price of Danazol 200 mg may vary depending on the brand, manufacturer, pack size, seller, and applicable pharmacy charges. Check the current listed price before ordering.

3. Can I order Danazol 200 mg online?
Yes, Danazol 200 mg can be ordered online where legally available. It is a prescription medicine, so a valid prescription may be required. Purchase only from a licensed pharmacy or authorized supplier.

4. Is Danazol 200 mg available from Steris Healthcare?
Availability depends on Steris Healthcare's current product range and stock status. Contact Steris Healthcare or an authorized distributor to confirm availability, strength, pack size, and ordering details.

5. What is Danazol 200 mg used for?
Danazol 200 mg is a synthetic hormone used to treat certain hormone-dependent conditions, including endometriosis and hereditary angioedema. It may also be prescribed for other conditions when considered appropriate by a healthcare professional.

6. What is the composition of Danazol 200 mg?
Danazol 200 mg contains Danazol 200 mg as the active pharmaceutical ingredient. The inactive ingredients may vary depending on the manufacturer and formulation.

7. Is a prescription required?
Yes, Danazol 200 mg should be used under medical supervision, and a prescription is generally required. The treatment dose and duration depend on the condition being treated.

8. How should Danazol 200 mg be taken?
Take Danazol 200 mg exactly as prescribed by your doctor. Follow the recommended dose and schedule, and do not change the dose or stop treatment without medical advice.

9. What should I know before buying Danazol 200 mg?
Before buying, verify the strength, manufacturer, batch number, expiry date, packaging, and storage instructions. Inform your doctor about liver or kidney problems, heart disease, abnormal vaginal bleeding, pregnancy, breastfeeding, allergies, and other medicines you are taking. Danazol should not be used during pregnancy.

10. How can I order Danazol 200 mg online?
Order Danazol 200 mg through a licensed online pharmacy or authorized pharmaceutical supplier. Provide a valid prescription, select the prescribed strength and pack size, and verify the product and delivery details before completing your purchase.