CARVEDIOL CR 20: Premier Extended-Release Carvedilol from Steris Healthcare

CARVEDIOL CR 20, featuring Carvedilol Extended Release 20mg, revolutionizes hypertension, heart failure, and post-MI management with once-daily dosing for 24-hour cardioprotection. This Steris Healthcare innovation delivers smooth blood pressure control, reduces hospitalizations by up to 65%, and improves survival in HFrEF patients, outperforming immediate-release alternatives.​

Discover why CARVEDIOL CR 20 excels in precision therapy—superior compliance, minimal fluctuations, and proven mortality benefits make it the top choice for cardiovascular health on sterisonline.com.​

What is CARVEDIOL CR 20?

CARVEDIOL CR 20 from Steris Healthcare is a controlled-release tablet containing Carvedilol phosphate 20mg equivalent, a vasodilating non-selective beta-blocker with alpha-1 blocking properties.​

• Extended-Release Technology: Matrix formulation ensures steady plasma levels over 24 hours, minimizing peak-trough effects vs. BID immediate-release.​

• Indications: Hypertension, NYHA Class II-IV heart failure, left ventricular dysfunction post-MI (LVEF ≤40%).​

• GMP Manufactured: Steris ensures bioavailability matching Coreg CR standards.​

Once-daily simplicity transforms patient adherence.​

Composition of CARVEDIOL CR 20

Active: Carvedilol 20mg (racemic mixture: S(-) enantiomer β1/β2/α1 blockade; R(+) α1 blockade only).​

Formulation Details

• Extended-Release Matrix: Hydrophilic polymers control dissolution for zero-order kinetics.

• Excipients: Microcrystalline cellulose, hypromellose, magnesium stearate—swallow whole, do not crush.​

• Bioequivalence: Matches IR carvedilol 10mg BID plasma profile.​

Steris Healthcare optimizes for Indian climate stability.​

Uses of CARVEDIOL CR 20

CARVEDIOL CR 20 treats essential hypertension, chronic heart failure (ischemic/non-ischemic), and post-myocardial infarction LV dysfunction.​

• Hypertension: 24-hour systolic/diastolic control, stroke prevention.

• Heart Failure: Improves LVEF, exercise tolerance; reduces mortality/hospitalizations.​

• Post-MI: Stabilizes remodeling in stable patients.​

Not for acute decompensation or bronchospastic disease.​

How CARVEDIOL CR 20 Works

Carvedilol in CARVEDIOL CR 20 provides triple action: β1-blockade reduces cardiac output; β2/α1 blockade vasodilates; antioxidant protects endothelium.​

Mechanism Breakdown

• Inhibits renin release, decreases vascular resistance.

• CR profile: Tmax 5-12 hours, steady-state in 1 week.​

• HF Benefits: ↓ hospitalizations 65%, ↑ survival 35% vs. placebo.​

Unique beyond β-selectives.​

Benefits of CARVEDIOL CR 20

Once-daily dosing boosts adherence 30% vs. BID; smoother BP control reduces CV events.​

• Proven in COMET trial: Superior mortality vs. metoprolol tartrate.

• Improves quality of life (MLHFQ scores), NYHA class.​

• Renally safe; no dose adjustment in mild-moderate impairment.​

Steris superior formulation.​

Dosage and Administration

Hypertension: Start 20mg OD x7-14 days → 40mg → 80mg if tolerated.​

Condition-Specific Dosing

• Heart Failure: 10mg OD → 20mg (2wks) → 40mg → 80mg; <85kg max 50mg equiv.​

• Post-MI LVD: 20mg OD x3-10 days → 40mg → 80mg.​

• Elderly/Switching: Lower start (20mg for 12.5mg BID IR).​

With food; monitor standing BP/HR.​

Side Effects of CARVEDIOL CR 20

Common (≥5%): Dizziness, fatigue, bradycardia, hypotension, diarrhea.​

Precautions and Warnings

Contraindications: Decompensated HF, 2°/3° AV block, sick sinus, severe bradycardia (<50bpm), asthma, cardiogenic shock.​

• Taper over 1-2 weeks to avoid rebound.

• Caution: PVD, Raynaud's, diabetes, hepatic impairment (Child-Pugh A/B).​

• Pregnancy C; avoid breastfeeding.​

Steris monitoring protocols advised.

Hypertension Management

24-hour control superior to IR; additive with diuretics.​

Heart Failure Therapy

Class I recommendation; target 80mg for max benefit.​

Post-MI Protection

Reduces remodeling, improves remodeling scores.​

Patient Experiences

Users report stable BP, fewer dizzy spells vs. BID dosing; HF patients note better exercise capacity.​

Lifestyle Integration

Low-sodium DASH diet, 30min aerobic exercise, stress reduction amplify benefits.​

Storage & Handling

15-30°C, dry place; Steris shelf-life 24 months unopened.​

Why CARVEDIOL CR 20 from Steris Healthcare?

Bioequivalent to global standards, affordable pricing, Jaipur-sourced reliability via sterisorder.com.​

Steris Healthcare Excellence

Leading Jaipur pharma delivering CARVEDIOL CR 20 nationwide.​

Frequently Asked Questions (FAQs)

1. What is CARVEDIOL CR 20 used for?

Hypertension, heart failure, post-MI LV dysfunction.​

2. CARVEDIOL CR 20 dosage for hypertension?

Start 20mg OD, max 80mg.​

3. Can CARVEDIOL CR be crushed?

No—destroys ER matrix.​

4. CARVEDIOL CR side effects dizziness?

Common; titrate slowly, rise gradually.​

5. CARVEDIOL CR vs Cardivas CR?

Bioequivalent; Steris quality edge.​

6. Safe in diabetes on CARVEDIOL CR?

Yes; masks hypo—monitor BG.​

7. Heart failure max dose CARVEDIOL CR?

80mg OD (<85kg: equiv 50mg).​

8. Buy CARVEDIOL CR 20 online India?

Sterisonline.com—Jaipur fast delivery.​

9. Abruptly stop CARVEDIOL CR?

No—taper 1-2 weeks avoid rebound.​

10. CARVEDIOL CR food interaction?

Take with food ↑ absorption 25%

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