Bethanechol Chloride (25mg) - Extended-Release Formula…..

Jul 15, 2024

Introduction

BETHNEVOID 25 contains Bethanechol Chloride 25 mg, a synthetic cholinergic agent used to stimulate bladder and gastrointestinal muscle activity. It mimics the effect of acetylcholine, primarily targeting muscarinic receptors, and is widely prescribed for the treatment of urinary retention and certain gastrointestinal motility disorders.Bethanechol is a preferred option for patients experiencing non-obstructive urinary retention or neurogenic bladder, as well as for selected cases of gastroparesis or postoperative ileus.

Bethanechol Chloride 25 mg – Mechanism of Action

Bethanechol acts as a muscarinic receptor agonist, stimulating smooth muscle contraction in the bladder and gastrointestinal tract. It enhances detrusor muscle tone in the urinary bladder, improving bladder emptying, and promotes gastric motility and tone.Unlike acetylcholine, Bethanechol is resistant to degradation by cholinesterase, which allows it to have a longer duration of action.

Uses of Bethanechol Chloride 25  mg Tablet

BETHNEVOID 25 is prescribed for:

  • Urinary retention (especially postoperative or postpartum)

  • Neurogenic bladder

  • Bladder atony

  • Gastroparesis

  • Postoperative ileus

  • Reflux esophagitis (off-label in some cases)

These bethanechol tablet uses are based on its parasympathomimetic effects that stimulate smooth muscle activity in the urinary and gastrointestinal systems.

Bethanechol Dosage and Administration

Bethanechol Chloride Dose for Adults:

  • Usual Dose: 10 to 50 mg orally, 3 to 4 times daily

  • Standard Initial Dose: Bethanechol 25 mg, 2 to 4 times per day

  • The lowest effective dose should be used and adjusted based on clinical response.

It should ideally be taken on an empty stomach, at least 1 hour before or 2 hours after meals, to avoid nausea or vomiting.

Bethanechol Dosage Recommendations

Indication Typical Dose
Urinary retention 25–50 mg 3–4 times daily
Postoperative ileus 10–25 mg 3 times daily
Neurogenic bladder 25 mg twice or thrice daily

 

Consult your physician for individual dose adjustments.

Benefits of BETHNEVOID 25

  • Improves bladder emptying and reduces urinary retention

  • Stimulates GI tract movement in postoperative or neurogenic conditions

  • Non-invasive oral option compared to catheterization or surgery

  • Useful in elderly and postpartum patients with reduced detrusor activity

Side Effects of Bethanechol Chloride 25 mg

Like all medications, Bethanechol Chloride may cause side effects, particularly due to overstimulation of the parasympathetic nervous system.

Common Side Effects:

  • Nausea and vomiting

  • Abdominal cramps

  • Diarrhea

  • Increased sweating

  • Flushing

Less Common but Serious Side Effects:

  • Hypotension

  • Bradycardia (slow heart rate)

  • Bronchospasm

  • Seizures (very rare)

Report any unusual symptoms to your doctor promptly.

Precautions and Warnings

  • Contraindicated in patients with:

    • Asthma

    • Peptic ulcer disease

    • Urinary tract obstruction

    • Intestinal obstruction

    • Hypotension or bradycardia

  • Use with caution in elderly patients and those with cardiovascular disease.

  • Do not take with food to minimize GI side effects.

Drug Interactions

Bethanechol may interact with:

  • Cholinesterase inhibitors (e.g., donepezil) – increased cholinergic effects

  • Beta-blockers – enhanced bradycardia or hypotension

  • Quinidine or Procainamide – may antagonize Bethanechol effects

Always inform your doctor about all ongoing medications.

Storage Instructions

  • Store at room temperature below 25°C

  • Keep the container tightly closed and away from moisture

  • Keep out of reach of children

Frequently Asked Questions (FAQ) – BETHNEVOID 25

1. What is Bethanechol 25 mg used for?

Bethanechol 25 mg is used for urinary retention, neurogenic bladder, and some gastrointestinal motility disorders. It helps stimulate the bladder and intestinal muscles to function properly.

2. How should I take BETHNEVOID 25?

Take Bethanechol Chloride 25 mg on an empty stomach, either one hour before or two hours after meals. This helps minimize side effects like nausea.

3. Is Bethanechol 25 mg safe for long-term use?

Bethanechol may be used long-term under medical supervision, especially for chronic urinary or gastrointestinal motility issues. Regular follow-up is necessary to monitor effectiveness and side effects.

4. What are the common side effects of Bethanechol Chloride?

Common side effects include:

  • Nausea

  • Sweating

  • Abdominal cramps

  • Diarrhea

  • Increased salivation

Serious side effects like slow heartbeat or breathing difficulty are rare.

5. Can Bethanechol be used during pregnancy?

Bethanechol should only be used in pregnancy if prescribed by a doctor. Its safety in pregnancy has not been fully established.

Conclusion

BETHNEVOID 25, containing Bethanechol Chloride 25 mg, is a trusted and effective medication for managing conditions such as urinary retention, neurogenic bladder, and certain gastrointestinal motility disorders. Its ability to mimic acetylcholine at muscarinic receptors allows it to restore smooth muscle function, especially in the urinary tract and stomach.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW

SHARE WITH