Acebrophylline (100mg) & Doxofylline (400mg) . .. . . ..

Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, and other obstructive airway disorders are becoming increasingly prevalent in India. Rising air pollution, occupational exposure to dust and chemicals, smoking, passive smoke, seasonal allergens, and recurrent respiratory infections have significantly contributed to the growing burden of chronic respiratory illnesses. These conditions often lead to symptoms such as breathlessness, persistent cough, chest tightness, wheezing, and excessive mucus production, which can severely affect daily activities and overall quality of life.

Effective management of chronic respiratory diseases requires medications that not only relieve airway constriction but also improve lung function, reduce mucus accumulation, and prevent frequent exacerbations. Combination therapies play a vital role in achieving these goals, especially in patients who do not respond adequately to single-drug treatment.

S PHYLLIN DX is a scientifically formulated respiratory medicine that combines Acebrophylline 100 mg and Doxofylline 400 mg in a single tablet. This dual bronchodilator combination is designed to provide powerful and sustained relief from bronchospasm, improve airflow, and enhance breathing comfort. Both components act through complementary mechanisms, offering enhanced efficacy with better tolerability.

S PHYLLIN DX is widely prescribed for long-term management of obstructive airway diseases and helps patients regain better control over their respiratory health when used under medical supervision.

Uses of S PHYLLIN DX

 Doxofylline tablet uses is primarily used in the treatment and long-term management of chronic respiratory disorders characterized by airway obstruction and inflammation.

Primary Uses

• Bronchial asthma

• Chronic obstructive pulmonary disease (COPD)

• Chronic bronchitis

• Emphysema

• Wheezing and shortness of breath

• Productive cough associated with mucus retention

• Respiratory distress due to airway narrowing

How the Combination Works

• Acebrophylline (100 mg):
  Acebrophylline is a xanthine derivative with bronchodilator and mucolytic properties. It relaxes the smooth muscles of the airways, improves airflow, and reduces mucus viscosity, making it easier to expel phlegm from the lungs. It also enhances mucociliary clearance, improving overall lung function.

• Doxofylline (400 mg):
  Doxofylline is a newer generation bronchodilator that works by inhibiting phosphodiesterase enzymes and relaxing bronchial muscles. Unlike traditional theophylline, doxofylline offers effective bronchodilation with fewer cardiac and gastrointestinal side effects, making it safer for long-term use.

Together, Acebrophylline and Doxofylline provide synergistic bronchodilation, reduce airway resistance, and improve breathing capacity in patients with chronic respiratory diseases.

Benefits of S PHYLLIN DX

Doxofylline 400 offers several clinical and practical benefits, making it a trusted choice in respiratory care.

1. Dual Bronchodilator Action

The combination ensures effective relaxation of airway muscles, resulting in improved airflow and easier breathing.

2. Improves Lung Function

Helps enhance pulmonary function parameters and oxygen exchange, particularly in asthma and COPD patients.

3. Mucus Clearance Support

Acebrophylline reduces mucus thickness, making cough more productive and clearing blocked airways.

4. Long-Lasting Symptom Relief

Provides sustained relief from breathlessness, wheezing, and chest tightness.

5. Reduced Frequency of Exacerbations

Regular use helps prevent acute flare-ups and hospital visits associated with chronic respiratory diseases.

6. Better Tolerability

Doxofylline is associated with fewer side effects compared to older bronchodilators, improving patient compliance.

7. Enhanced Quality of Life

Improves exercise tolerance, sleep quality, and daily functioning.

8. Suitable for Long-Term Management

Can be safely used for extended periods under medical supervision.

Dosage of S PHYLLIN DX

The dosage of doxofylline 400 mg should always be determined by a healthcare professional based on the patient’s age, severity of disease, and clinical response.

Recommended Dosage

• Adults: One tablet once or twice daily, as prescribed by the physician

• Taken preferably after meals to minimize gastric discomfort

Administration Guidelines

• Swallow the tablet whole with water

• Do not crush, chew, or break the tablet

• Take the medicine at the same time every day for consistent results

• Continue treatment even if symptoms improve, unless advised otherwise by your doctor

Missed Dose

• Take the missed dose as soon as you remember

• Skip the dose if it is close to the next scheduled dose

• Do not double the dose

Side Effects of S PHYLLIN DX

S PHYLLIN DX is generally well tolerated when taken as directed. However, some patients may experience mild to moderate side effects.

Common Side Effects

• Nausea

• Headache

• Mild stomach upset

• Dizziness

• Restlessness

Less Common Side Effects

• Palpitations

• Heartburn

• Tremors

• Insomnia

Rare but Serious Side Effects

• Severe allergic reactions such as rash, itching, or swelling

• Rapid or irregular heartbeat

• Severe gastrointestinal discomfort

If any severe or persistent side effects occur, immediate medical attention is recommended.

Warnings

• Not recommended for patients with severe cardiac disorders unless strictly advised

• Use with caution in individuals with liver or kidney impairment

• Not intended for immediate relief of acute asthma attacks

• Excessive consumption of caffeine-containing products should be avoided

• Do not exceed the prescribed dose

Precautions

• Inform your doctor about any history of heart disease, seizures, or gastrointestinal disorders

• Avoid smoking, as it may reduce the effectiveness of the medication

• Maintain adequate hydration to support mucus clearance

• Elderly patients should be monitored closely during therapy

• Pregnant and breastfeeding women should use only if clearly advised by a doctor

• Inform your doctor about all other medicines being taken to avoid interactions

Conclusion

S PHYLLIN DX, containing Acebrophylline 100 mg and Doxofylline 400 mg, is a powerful dual bronchodilator therapy designed to provide effective and sustained relief in chronic respiratory disorders such as asthma and COPD. By combining bronchodilation with mucus clearance support, it improves lung function, reduces symptom severity, and enhances overall quality of life.

Frequently Asked Questions (FAQs)

Q1. What is S PHYLLIN DX used for?

S PHYLLIN DX is used to treat asthma, COPD, chronic bronchitis, and other respiratory conditions involving airway obstruction.

Q2. Is S PHYLLIN DX a steroid?

No, it does not contain steroids. It works as a bronchodilator and mucolytic combination.

Q3. Can S PHYLLIN DX be taken long term?

Yes, it is suitable for long-term management when taken under medical supervision.

Q4. Does S PHYLLIN DX cause drowsiness?

Drowsiness is uncommon. Some patients may experience mild restlessness or insomnia.

Q5. Can S PHYLLIN DX be used in elderly patients?

Yes, but dose adjustment and monitoring may be required depending on overall health.