1200mg Mesalamine PR

Introduction

Mesalamine 1200 mg, the active ingredient in MESALMILE OD, is a locally acting anti-inflammatory agent primarily used to treat inflammatory bowel diseases (IBDs) such as Ulcerative Colitis (UC) and Crohn's disease. It belongs to the 5-aminosalicylic acid (5-ASA) class and works directly in the intestinal lining to reduce inflammation.

Mesalamine 1200mg Uses

MESALMILE OD is used for the:

• Induction and maintenance of remission in Ulcerative Colitis

• Mild to moderate Crohn’s disease (off-label use)

• Management of proctitis and distal colitis

• Preventing relapse of IBD symptoms

Mesalamine PR tablets deliver the drug throughout the colon, making it highly effective for long-term inflammation control.

How Mesalamine Works

Mesalamine acts locally in the colon to:

• Inhibit cyclooxygenase and lipoxygenase pathways

• Reduce pro-inflammatory cytokines and free radicals

• Suppress colonic inflammation and mucosal damage

This helps in healing the bowel lining and maintaining long-term remission in patients with IBD.

Mesalamine 1200mg Dosage and Administration

• Usual Adult Dose:

  • Induction: 2.4 to 4.8 grams per day, divided doses

  • Maintenance: 1.2 to 2.4 grams per day

• Administration:

  • Take MESALMILE OD once daily or as prescribed

  • Swallow whole – do not crush or chew

  • Take with or without food

Always follow your doctor’s dosing instructions. Do not exceed the recommended dose.

Mesalamine Side Effects

Common Side Effects:

• Nausea

• Headache

• Abdominal pain

• Flatulence

• Diarrhea

Less Common but Serious:

• Pancreatitis

• Kidney dysfunction (nephrotoxicity)

• Pericarditis or myocarditis

• Blood disorders (rare)

Seek immediate medical help if you experience chest pain, blood in urine, unusual fatigue, or shortness of breath.

Precautions and Warnings

• Use with caution in patients with:

  • Renal impairment

  • Liver disease

  • Sulfa allergy (cross-reactivity is low but possible)

• Monitor renal function (serum creatinine) regularly

• Not recommended for children under 5 years

Drug Interactions

Mesalamine may interact with:

• Azathioprine or 6-mercaptopurine – risk of myelosuppression

• NSAIDs – increased risk of kidney damage

• Antacids – may affect tablet dissolution

• Warfarin – may alter anticoagulant effects

Inform your healthcare provider about all medications and supplements you are taking.

Storage Instructions

• Store at a temperature below 30°C

• Keep away from moisture and sunlight

• Keep out of reach of children

FAQs About Mesalamine 1200mg (MESALMILE OD)

1. What is MESALMILE OD used for?

MESALMILE OD is used to treat and prevent flare-ups in ulcerative colitis and Crohn's disease by reducing inflammation in the intestines.

2. Is Mesalamine 1200 mg safe for long-term use?

Yes, it is generally safe for maintenance therapy, but kidney function must be monitored regularly.

3. Can MESALMILE OD be taken with food?

Yes, it can be taken with or without food, depending on patient comfort.

4. How long does it take for Mesalamine to work?

It may take 2–4 weeks to show significant improvement in symptoms.

5. Can I stop MESALMILE OD once I feel better?

No. Stopping abruptly may cause a relapse. Continue as prescribed for maintenance.

Conclusion

MESALMILE OD with Mesalamine PR 1200mg is a proven, effective therapy for managing ulcerative colitis and other IBDs. Its targeted release mechanism ensures delivery to the colon, offering maximum therapeutic benefit with minimal systemic side effects. Regular monitoring and adherence to therapy are key to long-term control.